{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:25:44Z","timestamp":1792758344907,"version":"4.5.0"},"reference-count":22,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Hospitals of Geneva, \u201cYoung Investigator Award\u201d","award":["PRD 12-2022-II"],"award-info":[{"award-number":["PRD 12-2022-II"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The emergence of 7T clinical MRI technology has sparked our interest in its ability to discern the complex structures of the hand. Our primary objective was to assess the sensory and motor nerve structures of the hand, specifically nerves and Pacinian corpuscles, with the dual purpose of aiding diagnostic endeavors and supporting reconstructive surgical procedures. Ethical approval was obtained to carry out 7T MRI scans on a cohort of volunteers. Four volunteers assumed a prone position, with their hands (N = 8) positioned in a \u201csuperman\u201d posture. To immobilize and maintain the hand in a strictly horizontal position, it was affixed to a plastic plate. Passive B0 shimming was implemented. Once high-resolution 3D images had been acquired using a multi-transmit head coil, advanced post-processing techniques were used to meticulously delineate the nerve fiber networks and mechanoreceptors. Across all participants, digital nerves were consistently located on the phalanges area, on average, between 2.5 and 3.5 mm beneath the skin, except within flexion folds where the nerve was approximately 1.8 mm from the surface. On the phalanges area, the mean distance from digital nerves to joints was approximately 1.5 mm. The nerves of the fingers were closer to the bone than to the surface of the skin. Furthermore, Pacinian corpuscles exhibited a notable clustering primarily within the metacarpal zone, situated on the palmar aspect. Our study yielded promising results, successfully reconstructing and meticulously describing the anatomy of nerve fibers spanning from the carpus to the digital nerve division, alongside the identification of Pacinian corpuscles, in four healthy volunteers (eight hands).<\/jats:p>","DOI":"10.3390\/diagnostics14121230","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T04:15:27Z","timestamp":1718165727000},"page":"1230","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["High-Resolution Magnetic Resonance Neurography at 7T: A Pilot Study of Hand Innervation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-6543","authenticated-orcid":false,"given":"Pauline C.","family":"Guillemin","sequence":"first","affiliation":[{"name":"Image Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2222-975X","authenticated-orcid":false,"given":"David","family":"Ferreira Branco","sequence":"additional","affiliation":[{"name":"Radiology Department, University Hospitals of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-3386","authenticated-orcid":false,"given":"Yacine","family":"M\u2019Rad","sequence":"additional","affiliation":[{"name":"Image Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loan","family":"Mattera","sequence":"additional","affiliation":[{"name":"Human Neuroscience Platform, Fondation Campus Biotech Geneva, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6500-1093","authenticated-orcid":false,"given":"Orane","family":"Lorton","sequence":"additional","affiliation":[{"name":"Image Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-6634","authenticated-orcid":false,"given":"Gian Franco","family":"Piredda","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthineers International AG, 1015 Lausanne, Switzerland"},{"name":"CIBM Center for Biomedical Imaging, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Klauser","sequence":"additional","affiliation":[{"name":"Advanced Clinical Imaging Technology, Siemens Healthineers International AG, 1015 Lausanne, Switzerland"},{"name":"CIBM Center for Biomedical Imaging, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-0961","authenticated-orcid":false,"given":"Roberto","family":"Martuzzi","sequence":"additional","affiliation":[{"name":"Human Neuroscience Platform, Fondation Campus Biotech Geneva, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Alexandre","family":"Poletti","sequence":"additional","affiliation":[{"name":"Radiology Department, University Hospitals of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rares","family":"Salomir","sequence":"additional","affiliation":[{"name":"Image Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Radiology Department, University Hospitals of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-4613","authenticated-orcid":false,"given":"Sana","family":"Boudabbous","sequence":"additional","affiliation":[{"name":"Image Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Radiology Department, University Hospitals of Geneva, 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0749-0712(21)01100-8","article-title":"Physiology of nerve repair: A research update","volume":"7","author":"Mitchell","year":"1991","journal-title":"Hand Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0266-7681(98)80060-0","article-title":"Distribution of human Pacinian corpuscles in the hand. 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