{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:11:56Z","timestamp":1760145116606,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000006","name":"U.S. Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-20-1-2000","N00014-22-1-2445","N00014-22-1-2818"],"award-info":[{"award-number":["N00014-20-1-2000","N00014-22-1-2445","N00014-22-1-2818"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A blood component analysis is an early step for evaluating inflammatory disorders, but it can be unfeasible in some settings. This pilot study assessed whether extracellular vesicle (EV) changes in perspiration are parallel to those occurring in blood as an alternative or complementary option to diagnose an inflammatory response. In parallel studies, EVs were analyzed in perspiration and blood obtained before and after five self-contained underwater breathing apparatus (SCUBA) divers at the National Aquarium in Baltimore performed a dive to 3.98 m of sea water for 40 min, and five non-divers performed an exercise routine at ambient atmospheric pressure. The results demonstrated that microparticles (MPs) are present in perspiration, their numbers increase in the blood in response to SCUBA diving, and the interleukin (IL)-1\u03b2 content increases. In contrast, while blood-borne MPs became elevated in response to terrestrial exercise, no statistically significant increases occurred in perspiration, and there were no changes in IL-1\u03b2. There were no statistically significant elevations in the exosomes in perspiration or blood in response to SCUBA diving and few changes following terrestrial exercise. These findings suggest that an MP perspiration analysis could be a non-invasive method for detecting inflammatory responses that can occur due to the oxidative stress associated with SCUBA diving.<\/jats:p>","DOI":"10.3390\/diagnostics14121293","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T04:21:28Z","timestamp":1718770888000},"page":"1293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microparticles in Human Perspiration as an Inflammatory Response Index"],"prefix":"10.3390","volume":"14","author":[{"given":"Zuha","family":"Imtiyaz","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena M.","family":"Bhopale","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2142-4924","authenticated-orcid":false,"given":"Awadhesh K.","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-1189","authenticated-orcid":false,"given":"Abid R.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3533-6124","authenticated-orcid":false,"given":"Stephen R.","family":"Thom","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1800010","DOI":"10.1002\/prca.201800010","article-title":"Eccrine Sweat as a Biofluid for Profiling Immune Biomarkers","volume":"12","author":"Katchman","year":"2018","journal-title":"Proteom. 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