{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:01:21Z","timestamp":1787508081821,"version":"build-2736575974"},"reference-count":80,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Lung transplantation (LT) constitutes the last therapeutic option for selected patients with end-stage respiratory disease. Primary graft dysfunction (PGD) is a form of severe lung injury, occurring in the first 72 h following LT and constitutes the most common cause of early death after LT. The presence of pulmonary hypertension (PH) has been reported to favor PGD development, with a negative impact on patients\u2019 outcomes while complicating medical management. Although several studies have suggested a potential association between pre-LT left ventricular diastolic dysfunction (LVDD) and PGD occurrence, the underlying mechanisms of such an association remain elusive. Importantly, the heterogeneity of the study protocols and the various inclusion criteria used to define the diastolic dysfunction in those patients prevents solid conclusions from being drawn. In this review, we aim at summarizing PGD mechanisms, risk factors, and diagnostic criteria, with a further focus on the interplay between LVDD and PGD development. Finally, we explore the predictive value of several diastolic dysfunction diagnostic parameters to predict PGD occurrence and severity.<\/jats:p>","DOI":"10.3390\/diagnostics14131340","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T13:06:40Z","timestamp":1719234400000},"page":"1340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Pre-Transplant Left Ventricular Diastolic Pressure on Primary Graft Dysfunction after Lung Transplantation: A Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3909-7337","authenticated-orcid":false,"given":"Jean Philippe","family":"Henry","sequence":"first","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6205-0087","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Carlier","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Higny","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Benoit","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4133-0191","authenticated-orcid":false,"given":"Olivier","family":"Xha\u00ebt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Blommaert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin-Mihail","family":"Telbis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8285-9369","authenticated-orcid":false,"given":"Benoit","family":"Robaye","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-2317","authenticated-orcid":false,"given":"Laurence","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Guedes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-5550","authenticated-orcid":false,"given":"Isabelle","family":"Michaux","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0071-5229","authenticated-orcid":false,"given":"Fabian","family":"Demeure","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-8515","authenticated-orcid":false,"given":"Maria-Luiza","family":"Luchian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universit\u00e9 Catholique de Louvain, CHU UCL Namur, 5530 Yvoir, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.healun.2017.07.021","article-title":"Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, part I: Definition and grading-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation","volume":"36","author":"Snell","year":"2017","journal-title":"J. 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