{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:57:18Z","timestamp":1788857838000,"version":"build-2803163510"},"reference-count":52,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Portal hypertension from chronic liver disease leads to the formation of collateral blood vessels called spontaneous portosystemic shunts (SPSS). These shunts may form from existing vessels or through neo-angiogenesis. Their location affects clinical outcomes due to varying risks and complications. This review summarizes current knowledge on SPSS, covering their clinical impact and management strategies. Recent data suggest that SPSS increases the risk of variceal bleeding, regardless of shunt size. The size of the shunt is crucial in the rising incidence of hepatic encephalopathy (HE) linked to SPSS. It also increases the risk of portopulmonary hypertension and portal vein thrombosis. Detecting and assessing SPSS rely on computed tomography (CT) and magnetic resonance imaging. CT enables precise measurements and the prediction of cirrhosis progression. Management focuses on liver disease progression and SPSS-related complications, like HE, variceal bleeding, and portopulmonary hypertension. Interventional radiology techniques such as balloon-occluded, plug-assisted, and coil-assisted retrograde transvenous obliteration play a pivotal role. Surgical options are rare but are considered when other methods fail. Liver transplantation (LT) often resolves SPSS. Intraoperative SPSS ligation is still recommended in patients at high risk for developing HE or graft hypoperfusion.<\/jats:p>","DOI":"10.3390\/diagnostics14131372","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T03:42:30Z","timestamp":1719546150000},"page":"1372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Implications and Management of Spontaneous Portosystemic Shunts in Liver Cirrhosis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5001-4852","authenticated-orcid":false,"given":"Simona","family":"Juncu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, \u201cSt. Spiridon\u201d Emergency County Hospital, Bd. Independentei No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horia","family":"Minea","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, \u201cSt. Spiridon\u201d Emergency County Hospital, Bd. Independentei No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-1232","authenticated-orcid":false,"given":"Irina","family":"Girleanu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, \u201cSt. Spiridon\u201d Emergency County Hospital, Bd. Independentei No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Huiban","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, \u201cSt. Spiridon\u201d Emergency County Hospital, Bd. Independentei No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-5961","authenticated-orcid":false,"given":"Cristina","family":"Muzica","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, \u201cSt. Spiridon\u201d Emergency County Hospital, Bd. 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Independentei No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2523-1633","authenticated-orcid":false,"given":"Florin","family":"Mihai","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-335X","authenticated-orcid":false,"given":"Camelia","family":"Cojocariu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, \u201cSt. Spiridon\u201d Emergency County Hospital, Bd. 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Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, \u201cSt. Spiridon\u201d Emergency County Hospital, Bd. Independentei No. 1, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-548X","authenticated-orcid":false,"given":"Ana-Maria","family":"Singeap","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, Universitatii Street No. 16, 700115 Iasi, Romania"},{"name":"Institute of Gastroenterology and Hepatology, \u201cSt. Spiridon\u201d Emergency County Hospital, Bd. 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