{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:13:57Z","timestamp":1760145237036,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: to prove the effectivity of fertility-sparing procedures in early-stage ovarian cancer by assessing pregnancy rates and obstetrical outcomes. Methods: we performed a retrospective multicenter study among 55 Spanish hospitals, collecting patients from 18 to 40 years old with diagnosis of early-stage ovarian cancer, epithelial (EOC) or non-epithelial (non-EOC), from January 2010 to December 2019. Data on the use of assisted reproductive techniques, pregnancy attempts and obstetrical outcomes were collected. Results: a total of 150 patients met inclusion criteria, 70 (46.6%) EOC and 80 (53.4%) non-EOC. Pregnancy attempts were reported in 51 (34%) patients, with 42 (28%) patients carrying the pregnancy to term. Among them, 30 (71.4%) underwent surgery alone and 12 (28.6%) had additional postoperative chemotherapy. A total of 32 (76.1% patients) had spontaneous pregnancies and 10 (23.9%) required in vitro fertilization. There was only one (2.4%) complication reported. Vaginal delivery was reported in twenty-nine (69%) patients and cesarean section in five (11.9%) patients. Conclusions: fertility-sparing management for ovarian cancer seems to be an option with proven good pregnancy rates and low complications. The selection of patients must consider strict criteria in order to maintain a good prognosis.<\/jats:p>","DOI":"10.3390\/diagnostics14131424","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T08:45:34Z","timestamp":1719996334000},"page":"1424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real Implication of Fertility-Sparing Surgery for Ovarian Cancer: Reproductive Outcomes"],"prefix":"10.3390","volume":"14","author":[{"given":"Marta","family":"Heras","sequence":"first","affiliation":[{"name":"Gynecology Department, Hospital Universitario Santa Cristina, 28009 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Alonso-Espias","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-8920","authenticated-orcid":false,"given":"Octavio","family":"Arencibia","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Universitario Materno Infantil, 06010 Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Minig","sequence":"additional","affiliation":[{"name":"Gynecology Department, IMED Hospitales, 46100 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lola","family":"Marti","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Universitario Bellvitge, 08907 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Dolores","family":"Diestro","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-8635","authenticated-orcid":false,"given":"Juan","family":"Cespedes","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Universitario de Donostia, 20014 San Sebastian, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-6802","authenticated-orcid":false,"given":"Isabel","family":"Niguez","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-8741","authenticated-orcid":false,"given":"Blanca","family":"Gil-Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-1817","authenticated-orcid":false,"given":"Berta","family":"Diaz-Feijoo","sequence":"additional","affiliation":[{"name":"Institute Clinic of Gynecology, Obstetrics and Neotatology, Hospital Clinic de Barcelona, 08007 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-8795","authenticated-orcid":false,"given":"Antoni","family":"Llueca","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital de Castell\u00f3n, 12004 Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Rosado","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital de Matar\u00f3, 08304 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-1752","authenticated-orcid":false,"given":"Sara","family":"Iacoponi","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Quir\u00f3n Madrid, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Lopez de la Manzanara","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Morales","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jose","family":"Fernandez-Galguera","sequence":"additional","affiliation":[{"name":"Gynecology Department, Complejo Asistencial de Zamora, 49022 Zamora, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Cano","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, 28922 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5150-2797","authenticated-orcid":false,"given":"Mikel","family":"Gorostidi","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital Universitario de Donostia, 20014 San Sebastian, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-7767","authenticated-orcid":false,"given":"Ignacio","family":"Zapardiel","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kajiyama, H., Suzuki, S., Yoshikawa, N., Kawai, M., Mizuno, K., Yamamuro, O., Nagasaka, T., Shibata, K., and Kikkawa, F. 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