{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:42:24Z","timestamp":1784698944895,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Lymphocytic choriomeningitis virus (LCMV) is a neglected rodent-borne arenavirus, primarily spread by common house mouse species. Acquired human infections range from asymptomatic to mild flu-like symptoms and self-resolving neurological diseases. In contrast, intrauterine LCMV infection is associated with high mortality and morbidity. Infection of the fetus often leads to fetal death, and surviving fetuses may develop vision impairment and central nervous system developmental disorders. LCMV is mainly diagnosed by serological methods using in-house indirect immunofluorescence assays. LCMV nucleic acid is detected by the nested RT-PCR method and confirmed by Sanger sequencing. In Hungary, 23 acquired lymphocytic choriomeningitis cases were diagnosed between 2017 and 2023. Ten out of 23 confirmed patients proved to be positive by the PCR method. Two cases of intrauterine LCMV infections were detected in 2019 and 2021, respectively. The IgG antibody titers measured in the infant\u2019s serum samples were much higher than the IgG titers of the maternal serum samples. Both IgM and IgA antibodies were detectable in the infants\u2019 sera. As the microbiological diagnosis of LCMV is rather challenging and the symptoms are very similar to the clinical picture of other common teratogenic pathogens such as cytomegalovirus or Toxoplasma\u00a0gondii, intrauterine LCMV infections might still be underdiagnosed.<\/jats:p>","DOI":"10.3390\/diagnostics14131436","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T03:48:56Z","timestamp":1720151336000},"page":"1436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lymphocytic Choriomeningitis Virus Infections in Hungary between 2017\u20132023\u2014Investigation of the First Congenital Infections"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1056-087X","authenticated-orcid":false,"given":"Anita","family":"Koroknai","sequence":"first","affiliation":[{"name":"National Reference Laboratory for Viral Zoonoses, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nagy","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Zoonoses, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Nagy","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Zoonoses, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary"},{"name":"Institute of Medical Microbiology, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolett","family":"Csonka","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Zoonoses, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Mezei","sequence":"additional","affiliation":[{"name":"Department of Epidemiological and Vaccination Surveillance, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Szomor","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Zoonoses, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-6890","authenticated-orcid":false,"given":"M\u00e1ria","family":"Tak\u00e1cs","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Viral Zoonoses, National Center for Public Health and Pharmacy, 1097 Budapest, Hungary"},{"name":"Institute of Medical Microbiology, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4149\/av_2013_02_160","article-title":"Lymphocytic choriomeningitis virus: Invisible but not innocent","volume":"57","year":"2013","journal-title":"Acta Virol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3201\/eid1607.091902","article-title":"High diversity and ancient common ancestry of lymphocytic choriomeningitis virus","volume":"16","author":"Palacios","year":"2010","journal-title":"Emerg. 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