{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:50:47Z","timestamp":1792219847277,"version":"4.4.0"},"reference-count":36,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"OCULUS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Purpose: This article introduces the Pentacam\u00ae Cornea OCT (optical coherence tomography). This advanced corneal imaging system combines rotating ultra-high-resolution spectral domain OCT with sub- 2-micron axial resolution and Scheimpflug photography. The purpose of this study is to present the first experience with the instrument and its potential for corneal diagnostics, including optical biopsy. Methods: In this prospective study, the Pentacam\u00ae Cornea OCT was used to image the corneas of seven patients. The novel wide-angle pericentric scan system enables optimal OCT imaging performance for the corneal layer structure over the entire width of the cornea, including the limbal regions. A detailed analysis of the resulting images assessed the synergism between the OCT and Scheimpflug photography. Results: The Pentacam\u00ae Cornea OCT demonstrated significantly improved image resolution and ability to individualize corneal layers with high quality. There is a synergism between the OCT high-definition signal to individualize details on the cornea and Scheimpflug photography to detect and quantify corneal scattering. The noncontact exam was proven safe, user-friendly, and effective for enabling optical biopsy. Conclusions: Pentacam\u00ae Cornea OCT is an advancement in corneal imaging technology. The ultra-high-resolution spectral domain OCT and Scheimpflug photography provide unprecedented detail and resolution, enabling optical biopsy and improving the understanding of corneal pathology. Further studies are necessary to compare and analyze the tomographic reconstructions of the cornea with the different wavelengths, which may provide helpful information for diagnosing and managing corneal diseases.<\/jats:p>","DOI":"10.3390\/diagnostics14131455","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T07:57:45Z","timestamp":1720425465000},"page":"1455","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combined Rotating Ultra-High-Resolution Spectral Domain OCT and Scheimpflug Imaging for In Vivo Corneal Optical Biopsy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6919-4606","authenticated-orcid":false,"given":"Renato","family":"Ambr\u00f3sio Jr.","sequence":"first","affiliation":[{"name":"Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro 20520-050, Brazil"},{"name":"Instituto de Olhos Renato Ambr\u00f3sio, Rio de Janeiro 20520-050, Brazil"},{"name":"Department of Ophthalmology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04021-001, Brazil"},{"name":"Brazilian Artificial Intelligence Networking in Medicine\u2014BrAIN, Rio de Janeiro 20520-050, Brazil"},{"name":"Brazilian Artificial Intelligence Networking in Medicine\u2014BrAIN, Macei\u00f3 57072-900, Brazil"},{"name":"Department of Ophthalmology, Federal University the State of Rio de Janeiro (UNIRIO), Rio de Janeiro 20520-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2353-9442","authenticated-orcid":false,"given":"Louise Pellegrino G.","family":"Esporcatte","sequence":"additional","affiliation":[{"name":"Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro 20520-050, Brazil"},{"name":"Instituto de Olhos Renato Ambr\u00f3sio, Rio de Janeiro 20520-050, Brazil"},{"name":"Department of Ophthalmology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04021-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1055","authenticated-orcid":false,"given":"Karolyna Andrade","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro 20520-050, Brazil"},{"name":"Instituto de Olhos Renato Ambr\u00f3sio, Rio de Janeiro 20520-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8330-6432","authenticated-orcid":false,"given":"Marcella Q.","family":"Salom\u00e3o","sequence":"additional","affiliation":[{"name":"Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro 20520-050, Brazil"},{"name":"Instituto de Olhos Renato Ambr\u00f3sio, Rio de Janeiro 20520-050, Brazil"},{"name":"Department of Ophthalmology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04021-001, Brazil"},{"name":"Instituto Benjamin Constant, Rio de Janeiro 22290-255, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Luiza","family":"Pereira-Souza","sequence":"additional","affiliation":[{"name":"Instituto de Olhos Renato Ambr\u00f3sio, Rio de Janeiro 20520-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8489-3621","authenticated-orcid":false,"given":"Bernardo T.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Rio de Janeiro 20520-050, Brazil"},{"name":"School of Engineering, University of Liverpool, Liverpool L69 3GH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1188-131X","authenticated-orcid":false,"given":"Aydano P.","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04021-001, Brazil"},{"name":"Brazilian Artificial Intelligence Networking in Medicine\u2014BrAIN, Rio de Janeiro 20520-050, Brazil"},{"name":"Brazilian Artificial Intelligence Networking in Medicine\u2014BrAIN, Macei\u00f3 57072-900, Brazil"},{"name":"Computing Institute, Federal University of Alagoas, Macei\u00f3 57072-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Marschall","sequence":"additional","affiliation":[{"name":"Department of Research & Development, OCULUS, Optikger\u00e4te GmbH, 35578 Wetzlar, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"OCT1","DOI":"10.1167\/iovs.16-19963","article-title":"The development, commercialization, and impact of Optical Coherence Tomography\u2013history of optical coherence tomography","volume":"57","author":"Fujimoto","year":"2016","journal-title":"Investig. 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