{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:15:06Z","timestamp":1782342906347,"version":"3.54.5"},"reference-count":9,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Spontaneous splenic rupture (SSR) is a relatively rare but potentially lethal complication of infectious mononucleosis (IM). While SSR is extremely rare in patients with proven IM, it is the most lethal complication of the infection (9% mortality rate) and can present completely asymptomatically or with abdominal pain and hemodynamic instability. As adolescents and young adults are the most affected population group, with this case report, we intend to raise the vigilance of any doctor treating those patients in the emergency department. We present the case of a 16-year-old patient with an atraumatic splenic rupture and hemoperitoneum secondary to an Epstein\u2013Barr virus (EBV) infection. The patient underwent an exploratory laparotomy, and a splenectomy was performed. This case demonstrates that, even if SSR in patients with IM is extremely rare, it should always be considered in a patient with a relevant clinical presentation.<\/jats:p>","DOI":"10.3390\/diagnostics14141536","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T08:48:29Z","timestamp":1721206109000},"page":"1536","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spontaneous Splenic Rupture Secondary to Infectious Mononucleosis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6027-6378","authenticated-orcid":false,"given":"Ismini","family":"Kountouri","sequence":"first","affiliation":[{"name":"Department of General Surgery, General Hospital of Katerini, 60100 Katerini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3899-355X","authenticated-orcid":false,"given":"Evangelos N.","family":"Vitkos","sequence":"additional","affiliation":[{"name":"Department of General Surgery, General Hospital of Katerini, 60100 Katerini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periklis","family":"Dimasis","sequence":"additional","affiliation":[{"name":"Department of General Surgery, General Hospital of Katerini, 60100 Katerini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltiadis","family":"Chandolias","sequence":"additional","affiliation":[{"name":"Department of General Surgery, General Hospital of Katerini, 60100 Katerini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Martha","family":"Galani Manolakou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, General Hospital of Katerini, 60100 Katerini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Gkiatas","sequence":"additional","affiliation":[{"name":"Department of General Surgery, General Hospital of Katerini, 60100 Katerini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Manolakaki","sequence":"additional","affiliation":[{"name":"Department of General Surgery, General Hospital of Katerini, 60100 Katerini, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E737","DOI":"10.1097\/PEC.0000000000001520","article-title":"Adolescent with Spontaneous Splenic Rupture as a Cause of Hemoperitoneum in the Emergency Department: Case Report and Literature Review","volume":"36","year":"2020","journal-title":"Pediatr. Emerg. Care."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"774","DOI":"10.12659\/AJCR.893919","article-title":"Epstein-barr virus-associated atraumatic spleen laceration presenting with neck and shoulder pain","volume":"16","author":"Sergent","year":"2015","journal-title":"Am. J. Case Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/014107689208500812","article-title":"Splenic rupture and infectious mononucleosis-splenectomy, splenorrhaphy or non-operative management?","volume":"85","author":"Purkiss","year":"1992","journal-title":"J. R. Soc. Med."},{"key":"ref_4","first-page":"2016","article-title":"Atraumatic splenic rupture secondary to Epstein-Barr virus infection","volume":"2017","author":"Barnwell","year":"2017","journal-title":"BMJ Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12659\/AJCR.883739","article-title":"Spontaneous splenic rupture: A rare life-threatening condition; diagnosed early and managed successfully","volume":"14","author":"Weaver","year":"2013","journal-title":"Am. J. Case Rep."},{"key":"ref_6","first-page":"485","article-title":"EBV: Not your everyday benign virus","volume":"83","author":"Ruymbeke","year":"2020","journal-title":"Acta Gastroenterol. Belg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.csm.2019.06.002","article-title":"Infectious Mononucleosis Management in Athletes","volume":"38","author":"Ceraulo","year":"2019","journal-title":"Clin. Sports Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2298\/SARH160629207O","article-title":"Spontaneous splenic rupture in infectious mononucleosis","volume":"146","year":"2018","journal-title":"Srp. Arh. Celok. Lek."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e230259","DOI":"10.1136\/bcr-2019-230259","article-title":"Spontaneous splenic rupture in a patient with infectious mononucleosis","volume":"12","author":"Baker","year":"2019","journal-title":"BMJ Case Rep."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/14\/1536\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:17:53Z","timestamp":1760109473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/14\/1536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":9,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["diagnostics14141536"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14141536","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]}}}