{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:51Z","timestamp":1787027931686,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation (NRF)","award":["2021R1A2C1093636"],"award-info":[{"award-number":["2021R1A2C1093636"]}]},{"name":"National Research Foundation (NRF)","award":["IBC-2021-01"],"award-info":[{"award-number":["IBC-2021-01"]}]},{"DOI":"10.13039\/501100003725","name":"Ministry of Education of Korea","doi-asserted-by":"publisher","award":["2021R1A2C1093636"],"award-info":[{"award-number":["2021R1A2C1093636"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Ministry of Education of Korea","doi-asserted-by":"publisher","award":["IBC-2021-01"],"award-info":[{"award-number":["IBC-2021-01"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute for Bio-Medical Convergence","award":["2021R1A2C1093636"],"award-info":[{"award-number":["2021R1A2C1093636"]}]},{"name":"Institute for Bio-Medical Convergence","award":["IBC-2021-01"],"award-info":[{"award-number":["IBC-2021-01"]}]},{"name":"Incheon St. Mary\u2019s Hospital","award":["2021R1A2C1093636"],"award-info":[{"award-number":["2021R1A2C1093636"]}]},{"name":"Incheon St. Mary\u2019s Hospital","award":["IBC-2021-01"],"award-info":[{"award-number":["IBC-2021-01"]}]},{"name":"Catholic University of Korea","award":["2021R1A2C1093636"],"award-info":[{"award-number":["2021R1A2C1093636"]}]},{"name":"Catholic University of Korea","award":["IBC-2021-01"],"award-info":[{"award-number":["IBC-2021-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Purpose: Therapeutic hypothermia (TH) is widely acknowledged as one of the interventions for preventing hypoxic ischemic brain injury in comatose patients following cardiac arrest (CA). Despite its recognized efficacy, recent debates have questioned its effectiveness. This preclinical study evaluated the impact of TH on brain glucose metabolism, utilizing fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) in a rat model of CA. Methods: Asphyxia CA was induced in Sprague-Dawley rats using vecuronium. Brain PET images using 18F-FDG were obtained from 21 CA rats, who were randomized to receive either TH or no intervention. Of these, 9 rats in the TH group received hypothermia under general anesthesia and mechanical ventilation for eight hours, while the remaining 12 rats in the non-TH group were observed without intervention. We conducted regional and voxel-based analyses of standardized uptake values relative to the pons (SUVRpons) to compare the two groups. Results: Survival rates were identical in both the TH and non-TH groups (67%). There was no discernible difference in the SUVRpons across the brain cortical regions between the groups. However, in a subgroup analysis of the rats that did not survive (n = 7), those in the TH group (n = 3) displayed significantly higher SUVRpons values across most cortical regions compared to those in the non-TH group (n = 4), with statistical significance after false-discovery rate correction (p &lt; 0.05). Conclusions: The enhancement in SUVRpons due to TH intervention was only observed in the cortical regions of rats with severe encephalopathy that subsequently died. These findings suggest that the beneficial effects of TH on brain glucose metabolism in this asphyxia CA model may be confined to cases of severe ischemic encephalopathy.<\/jats:p>","DOI":"10.3390\/diagnostics14151674","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T09:34:17Z","timestamp":1722591257000},"page":"1674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Therapeutic Hypothermia on Ischemic Brain Injury in a Rat Model of Cardiac Arrest: An Assessment Using 18F-FDG PET"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-9806","authenticated-orcid":false,"given":"Daehee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Incheon St. Mary\u2019s Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea"},{"name":"Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon Jeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Hee","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-7182","authenticated-orcid":false,"given":"Bom Sahn","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-6280","authenticated-orcid":false,"given":"Hai-Jeon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1056\/NEJMoa003289","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","volume":"346","author":"Bernard","year":"2002","journal-title":"N. 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