{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:17:59Z","timestamp":1760145479645,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health to IRCCS Humanitas Research Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Malignant neoplasms originating from or involving the mediastinum represent a diagnostic and therapeutic challenge when they are in contact with nearby cardiovascular structures. We aimed to test the diagnostic accuracy of cine-magnetic resonance imaging (cine-MRI) in detecting the infiltration of cardiovascular structures in cases with uncertain or equivocal findings from contrast-enhanced Computed Tomography (CT) scanning. Methods: Fifty patients affected by tumors with a suspected invasion of mediastinal cardiovascular structures at the pre-operative chest CT scan stage underwent cine-MRI before surgery at our Institution. Intraoperative findings and the histological post-surgical report were used as a reference standard to define infiltration. Inter- and intra-observer agreement for CT scans and cine-MRI were also computed over a homogenous sample of 14 patients. Results: Cine-MRI had a higher negative predictive value (93% vs. 54%, p &lt; 0.001) than CT scans, higher sensitivity (91% vs. 16%, p &lt; 0.001), as well as greater accuracy (66% vs. 50%, p &lt; 0.001) in detecting cardiovascular invasion. Cine-MRI also showed better inter- and intra-observer agreement for infiltration detection. Conclusions: Cine-MRI outperforms conventional contrast-enhanced chest CT scans in the preoperative assessment of cardiovascular infiltration by mediastinal or pulmonary tumors, making it a useful imaging modality in the preoperative staging and evaluation of patients with equivocal findings at the chest CT scan stage.<\/jats:p>","DOI":"10.3390\/diagnostics14151682","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T16:14:58Z","timestamp":1722615298000},"page":"1682","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Cine-Magnetic Resonance Imaging in the Assessment of Mediastinal Masses with Uncertain\/Equivocal Findings from Pre-Operative Computed Tomography Scanning"],"prefix":"10.3390","volume":"14","author":[{"given":"Umberto","family":"Cariboni","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-3568","authenticated-orcid":false,"given":"Lorenzo","family":"Monti","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-6797","authenticated-orcid":false,"given":"Emanuele","family":"Voulaz","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrem","family":"Civilini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy"},{"name":"Division of Vascular Surgery, IRCCS Humanitas Research Hospital, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Citterio","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, IRCCS Humanitas Research Hospital, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanza","family":"Lisi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy"},{"name":"Department of Diagnostic and Interventional Radiology, IRCCS Humanitas Research Hospital, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Marulli","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.21037\/jtd.2016.02.55","article-title":"Management of large mediastinal masses: Surgical and anesthesiological considerations","volume":"8","author":"Li","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.21037\/jtd.2019.07.09","article-title":"Salvage resection of advanced mediastinal tumors","volume":"11","author":"Maurizi","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.thorsurg.2021.07.008","article-title":"Assessment of Operability and Resectability in Lung Cancer","volume":"31","author":"Shamji","year":"2021","journal-title":"Thorac. Surg. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1378\/chest.07-1380","article-title":"Treatment of non-small cell lung cancer, stage IIIB: ACCP evidence-based clinical practice guidelines (2nd edition)","volume":"132","author":"Jett","year":"2007","journal-title":"Chest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1378\/chest.07-1382","article-title":"Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd ed)","volume":"132","author":"Shen","year":"2007","journal-title":"Chest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.21037\/jtd.2018.06.04","article-title":"Radical thymectomy versus conservative thymomectomy in the surgical treatment of thymic malignancies","volume":"7","author":"Voulaz","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Comacchio, G.M., Dell\u2019Amore, A., Marino, M.C., Russo, M.D., Schiavon, M., Mammana, M., Faccioli, E., Lorenzoni, G., Gregori, D., and Pasello, G. (2021). Vascular Involvement in Thymic Epithelial Tumors: Surgical and Oncological Outcomes. Cancers, 13.","DOI":"10.3390\/cancers13133355"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0022-5223(95)70235-0","article-title":"Risk analysis and long-term survival in patients undergoing extended resection of locally advanced lung cancer","volume":"110","author":"Izbicki","year":"1995","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1590\/S1806-37132009000900003","article-title":"Characteristics associated with complete surgical resection of primary malignant mediastinal tumors","volume":"110","author":"Gross","year":"2009","journal-title":"J. Bras. Pneumol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1010-7940(02)00204-X","article-title":"Resection of advanced thoracic malignancies requiring cardiopulmonary bypass","volume":"22","author":"Vaporciyan","year":"2002","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/ejcts\/ezu376","article-title":"Successful resection of thymoma directly invading the right atrium under cardiopulmonary bypass","volume":"48","author":"Patella","year":"2015","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.21037\/jtd-21-1324","article-title":"Venovenous extracorporeal membrane oxygenation-assisted tracheobronchial surgery: A retrospective analysis and literature review","volume":"13","author":"Chen","year":"2021","journal-title":"J. Thorac. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/cc10490","article-title":"Extracorporeal membrane oxygenation","volume":"15","author":"Gattinoni","year":"2011","journal-title":"Crit. Care"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Suk, P., \u0160r\u00e1mek, V., and \u010cundrle, I. (2021). Extracorporeal membrane oxygenation use in thoracic surgery. Membranes, 11.","DOI":"10.3390\/membranes11060416"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.athoracsur.2022.04.039","article-title":"Outcomes of Extracorporeal Membrane Oxygenation for Support of Patients with Thoracic Neoplasm","volume":"114","author":"Putnam","year":"2022","journal-title":"Ann. Thorac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1177\/02676591211011044","article-title":"Perioperative, protective use of extracorporeal membrane oxygenation in complex thoracic surgery","volume":"37","author":"Zhang","year":"2022","journal-title":"Perfusion"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/ejcts\/ezu162","article-title":"Extracorporeal membrane oxygenation support for complex tracheo-bronchial procedures","volume":"47","author":"Lang","year":"2015","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_18","first-page":"3","article-title":"Determining extent of invasion and follow-up of thymic epithelial malignancies","volume":"19","author":"Benveniste","year":"2019","journal-title":"Mediastinum"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1159\/000472256","article-title":"Relationship between Contrast-Enhanced CT and Clinicopathological Characteristics and Prognosis of Non-Small Cell Lung Cancer","volume":"40","author":"Yang","year":"2017","journal-title":"Oncol. Res. Treat."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1183\/09031936.02.00270802","article-title":"Computed tomography in staging for lung cancer","volume":"35","author":"Verschakelen","year":"2002","journal-title":"Eur. Respir. J."},{"key":"ref_21","first-page":"77","article-title":"Assessment of the accuracy of diagnostic chest CT scanning. Impact on lung cancer management","volume":"81","author":"Cangemi","year":"1996","journal-title":"Int. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S1010-7940(02)00581-X","article-title":"Comparison of clinical and surgical-pathologic staging of the patients with non-small cell lung carcinoma","volume":"22","author":"Cetinkaya","year":"2002","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S1064-9689(21)00640-1","article-title":"MR imaging of pulmonary and mediastinal malignancies","volume":"8","author":"Thompson","year":"2000","journal-title":"Magn. Reson. Imaging Clin. N. Am."},{"key":"ref_24","first-page":"24","article-title":"Cine-MR in the assessment of the cardiovascular structures in extensive mediastinal pathology","volume":"83","author":"Giovagnoni","year":"1992","journal-title":"Radiol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/jmri.20378","article-title":"Usefulness of magnetic resonance imaging for evaluation of cardiovascular invasion: Evaluation of sliding motion between thoracic mass and adjacent structures on cine MR images","volume":"22","author":"Seo","year":"2005","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/jmri.24335","article-title":"Usefulness of India ink artifact in steady-state free precession pulse sequences for detection and quantification of intramyocardial fat","volume":"40","author":"Aquaro","year":"2014","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/jmri.21895","article-title":"Fat and water magnetic resonance imaging","volume":"31","author":"Bley","year":"2010","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1081\/JCMR-120013298","article-title":"Improved accuracy of quantitative assessment of left ventricular volume and ejection fraction by geometric models with steady-state free precession","volume":"4","author":"Thiele","year":"2002","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4103\/0028-3886.258027","article-title":"Diagnostically useful MRI artifact\u2014India ink artifact","volume":"67","author":"Indiran","year":"2019","journal-title":"Neurol. India"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11547-020-01245-4","article-title":"Multimodality imaging in chronic heart failure","volume":"126","author":"Carerj","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1148\/rg.2018170091","article-title":"Mediastinal and pleural MR imaging: Practical approach for daily practice","volume":"38","author":"Raptis","year":"2018","journal-title":"Radiographics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"566","DOI":"10.12659\/PJR.898242","article-title":"Utility of Electrocardiography (ECG)-Gated Computed Tomography (CT) for Preoperative Evaluations of Thymic Epithelial Tumors","volume":"25","author":"Ozawa","year":"2016","journal-title":"Pol. J. Radiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12968-018-0493-4","article-title":"Importance of operator training and rest perfusion on the diagnostic accuracy of stress perfusion cardiovascular magnetic resonance","volume":"20","author":"Villa","year":"2018","journal-title":"J. Cardiovasc. Magn. 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