{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:18:53Z","timestamp":1760145533617,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cone beam computed tomography (CBCT) can provide precise information about complex anatomical structures as it is characterised by rapid volumetric image acquisition with high resolution. The aim of this study was to provide measurements for 20 ancient skulls of the Samnite people found in the necropolis of Opi, a small and isolated mountain village in Abruzzo, a region in central Italy. All the images (left and right) of the 20 ancient skulls from Opi were acquired. All the data are the property of the Department of Innovative Technologies in Medicine and Dentistry of G. D\u2019Annunzio University, Chieti, and different parameters (area and volume) were measured and evaluated. The mean and standard deviation of the facial measurements were also calculated. All the data were subjected to statistical analysis. CBCT scan data of 20 fossil skulls did not show significant values regarding the MS area and the volume between the right and left sides. In the ancient skulls, no difference was found between the right and left sides.<\/jats:p>","DOI":"10.3390\/diagnostics14151683","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:37:30Z","timestamp":1722843450000},"page":"1683","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Three-Dimensional Analysis of the Maxillary Sinuses in Ancient Crania Dated to the V\u2013VI Centuries BCE from Opi (Italy): Volumetric Measurements in Ancient Skulls from the Necropolis of Opi, Abruzzi, Italy"],"prefix":"10.3390","volume":"14","author":[{"given":"Felice","family":"Festa","sequence":"first","affiliation":[{"name":"Department of Innovative Technologies in Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggero","family":"D\u2019Anastasio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u2018G. D\u2019Annunzio\u2019 of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Benazzi","sequence":"additional","affiliation":[{"name":"Department of Cultural Heritage, University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-1319","authenticated-orcid":false,"given":"Monica","family":"Macr\u00ec","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine & Dentistry, University \u201cG. D\u2019Annunzio\u201d of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117433","DOI":"10.1016\/j.jns.2021.117433","article-title":"Olfaction and anosmia: From ancient times to COVID-19","volume":"425","author":"Mathis","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/joa.13561","article-title":"Leonardo da Vinci and dental anatomy","volume":"240","author":"Schuez","year":"2022","journal-title":"J. Anat."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Przysta\u0144ska, A., Kulczyk, T., Rewekant, A., Sroka, A., Jo\u0144czyk-Potoczna, K., Gawrio\u0142ek, K., and Czajka-Jakubowska, A. (2018). The association between maxillary sinus dimensions and midface parameters during human postnatal growth. Biomed Res. Int., 2018.","DOI":"10.1155\/2018\/6391465"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Arriagada-Vargas, C., Abeleira-Pazos, M.T., Outumuro-Rial, M., Garc\u00eda-Mato, E., Varela-Aneiros, I., Limeres-Posse, J., and Diniz-Freitas, M. (2022). Rare disorders: Diagnosis and therapeutic planning for patients seeking orthodontic treatment. J. Clin. Med., 11.","DOI":"10.3390\/jcm11061527"},{"key":"ref_5","first-page":"33","article-title":"Functional Matrix Hypothesis: A Review of Literature","volume":"1","author":"Kaur","year":"2021","journal-title":"Surf. Plasmon Reson."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mar\u00e9chal, L., and Heuz\u00e9, Y. (2021). Interaction Between Environmental Temperature and Craniofacial Morphology in Human Evolution: A Focus on Upper Airway, CRC Press.","DOI":"10.1201\/9781003206231-7"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bozhikova, E., and Uzunov, N. (2021). Morphological Aspects of the Maxillary Sinus. Paranasal Sinuses Anatomy and Conditions, IntechOpen Limited.","DOI":"10.5772\/intechopen.99250"},{"key":"ref_8","unstructured":"Kim, S. (2022). Three-Dimensional Variation in Maxillary Sinus Anatomy: Implications for Health Disparities in Sinonasal Disease. [Ph.D. Dissertation, University of North Texas Health Science Center at Fort Worth]."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Whyte, A., and Boeddinghaus, R. (2019). The maxillary sinus: Physiology, development and imaging anatomy. Dentomaxillofacial Radiol., 48.","DOI":"10.1259\/dmfr.20190205"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.5603\/FM.a2019.0106","article-title":"Three-dimensional volumetric analysis of the maxillary sinus: A cone-beam computed tomography study","volume":"79","author":"Gulec","year":"2020","journal-title":"Folia Morphol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00405-019-05383-y","article-title":"Three-dimensional evaluation of maxillary sinus volume in different age and sex groups using CBCT","volume":"276","author":"Colak","year":"2019","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.ijporl.2015.05.032","article-title":"Development of the maxillary sinus from birth to age 18. Postnatal growth pattern","volume":"79","author":"Kociemba","year":"2015","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aanat.2018.01.008","article-title":"Three-dimensional CAD\/CAM imaging of the maxillary sinus in ageing process","volume":"218","author":"Lovasova","year":"2018","journal-title":"Ann. Anat."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Andersen, T.N., Darvann, T.A., Murakami, S., Larsen, P., Senda, Y., Bilde, A., Buchwald, C.v., and Kreiborg, S. (2018). Accuracy and precision of manual segmentation of the maxillary sinus in MR images\u2014A method study. Br. J. Radiol., 91.","DOI":"10.1259\/bjr.20170663"},{"key":"ref_15","first-page":"ZC67","article-title":"Sexual Dimorphism of Maxillary Sinus: A Morphometric Analysis using Cone Beam Computed Tomography","volume":"11","author":"Urooge","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4103\/jiaomr.jiaomr_130_18","article-title":"The relationship between the roots and furcation of the maxillary first molar to the maxillary sinus: A cone-beam computed tomography study","volume":"30","author":"Katti","year":"2018","journal-title":"J. Indian Acad. Oral Med. Radiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33545\/26644436.2022.v5.i4a.278","article-title":"Volumetric measurement of maxillary sinus volume by MDCT","volume":"5","author":"Sah","year":"2022","journal-title":"Int. J. Radiol. Diagn. Imaging"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Weiss, R., and Read-Fuller, A. (2019). Cone beam computed tomography in oral and maxillofacial surgery: An evidence-based review. Dent. J., 7.","DOI":"10.3390\/dj7020052"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Icaro, I., Alem\u00e1n, I., and Viciano, J. (2023). Stable Isotopes Unveil Dietary Trends in the Samnite and Peligni Communities of Opi Val Fondillo and Sulmona S. Lucia (V\u2013VI Centuries BCE, Abruzzo, Central Italy). Biology, 12.","DOI":"10.3390\/biology12111382"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.archoralbio.2014.09.003","article-title":"Odontometric sex estimation on three populations of the Iron Age from Abruzzo region (central\u2013southern Italy)","volume":"60","author":"Viciano","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"ref_21","first-page":"85","article-title":"Prima dei Sanniti. Le necropoli dell\u2019Abruzzo meridionale","volume":"115","author":"Faustoferri","year":"2003","journal-title":"M\u00e9langes De Fran\u00e7aise De Rome"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s11547-017-0758-2","article-title":"Cone beam computed tomography for dental and maxillofacial imaging: Technique improvement and low-dose protocols","volume":"122","author":"Feragalli","year":"2017","journal-title":"La Radiol. Medica"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Macr\u00ec, M., Rendina, F., Feragalli, B., Pegreffi, F., and Festa, F. (2023). Prevalence of Ponticulus Posticus and Migraine in 220 Orthodontic Patients: A Cross-Sectional Study. Biology, 12.","DOI":"10.3390\/biology12030471"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Macr\u00ec, M., Medori, S., Varvara, G., and Festa, F. (2023). A Digital 3D Retrospective Study Evaluating the Efficacy of Root Control during Orthodontic Treatment with Clear Aligners. Appl. Sci., 13.","DOI":"10.3390\/app13031540"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Maspero, C., Farronato, M., Bellincioni, F., Annibale, A., Machetti, J., Abate, A., and Cavagnetto, D. (2020). Three-dimensional evaluation of maxillary sinus changes in growing subjects: A retrospective cross-sectional study. Materials, 13.","DOI":"10.3390\/ma13041007"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1046\/j.1469-7580.1997.19040533.x","article-title":"Growth pattern of the maxillary sinus in the Japanese macaque (Macaca fuscata): Reflections on the structural role of the paranasal sinuses","volume":"190","author":"Koppe","year":"1997","journal-title":"J. Anat."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1259\/dmfr.23.3.7835518","article-title":"Age changes in the volume of the human maxillary sinus: A study using computed tomography","volume":"23","author":"Ariji","year":"1994","journal-title":"Dentomaxillofacial Radiol."},{"key":"ref_28","first-page":"e1","article-title":"Maxillary and mandibular base size in ancient skulls and of modern humans from Opi, Abruzzi, Italy: A cross-sectional study","volume":"11","author":"Festa","year":"2010","journal-title":"World J. Orthop."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/ajpa.21377","article-title":"Changes in skeletal robusticity in an iron age agropastoral group: The samnites from the Alfedena necropolis (Abruzzo, Central Italy)","volume":"144","author":"Sparacello","year":"2011","journal-title":"Am. J. Phys. Anthropol."},{"key":"ref_30","first-page":"14","article-title":"Variation in paranasal pneumatisation between Mid-Late Pleistocene hominins","volume":"31","author":"Buck","year":"2019","journal-title":"Bull. Et M\u00e9moires De La Soci\u00e9t\u00e9 D\u2019anthropologie De Paris"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ajpa.1330470209","article-title":"Eskimo craniofacial morphology, cold stress and the maxillary sinus","volume":"47","author":"Shea","year":"1977","journal-title":"Am. J. Phys. Anthropol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ajpa.23841","article-title":"Nasal cavity and maxillary sinuses form variation among modern humans of Asian descent","volume":"169","author":"Evteev","year":"2019","journal-title":"Am. J. Phys. Anthropol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1098\/rspb.2006.3629","article-title":"Developmental response to cold stress in cranial morphology of Rattus: Implications for the interpretation of climatic adaptation in fossil hominins","volume":"273","author":"Rae","year":"2006","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.5603\/FM.a2018.0089","article-title":"Assessment of paranasal sinus parameters according to ancient skulls\u2019 gender and age by using cone-beam computed tomography","volume":"78","author":"Demiralp","year":"2019","journal-title":"Folia Morphol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/15\/1683\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:29:27Z","timestamp":1760110167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/15\/1683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,3]]},"references-count":34,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["diagnostics14151683"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14151683","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2024,8,3]]}}}