{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:14:12Z","timestamp":1787235252346,"version":"build-2736575974"},"reference-count":147,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cutaneous squamous cell carcinoma (cSCC) is the second-most-prevalent malignancy in humans. A delayed diagnosis of cSCC leads to heightened invasiveness and positive surgical margins. Bowen\u2019s disease (BD) represents an early form of cSCC and presents as a small erythematous, photo-distributed, psoriasiform plaque. Although certain dermoscopy features in BD are quite characteristic, histopathology remains the gold standard for diagnosis and provides a severity-scoring system that assists in guiding appropriate treatment strategies. The classification of precancerous lesions of the vulva and penis has undergone multifarious transformations due to variations in clinical and histopathological characteristics. Presently, erythroplasia of Queyrat is categorized as a clinical variant of penile intraepithelial neoplasia (PeIN). The diagnoses of vulvar intraepithelial neoplasia (VIN) and PeIN present significant challenges and typically necessitate one or more biopsies, potentially guided by dermoscopy. Aceto-white testing demonstrates a notably high negative predictive value for genital precancerous lesions. Histopathological examination represents the gold-standard diagnosis in VIN and PeIN, while p16 and p53 immunostainings alongside HPV testing provide crucial diagnostic clues. The histopathologic features, degree of differentiation, and associations with lichen planus, lichen sclerosus, and HPV guide the selection of conservative treatments or surgical excision.<\/jats:p>","DOI":"10.3390\/diagnostics14161799","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T12:40:07Z","timestamp":1723812007000},"page":"1799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Squamous Cell Carcinoma In Situ\u2014The Importance of Early Diagnosis in Bowen Disease, Vulvar Intraepithelial Neoplasia, Penile Intraepithelial Neoplasia, and Erythroplasia of Queyrat"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-0102","authenticated-orcid":false,"given":"Lucian G.","family":"Scurtu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology I, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2746-6153","authenticated-orcid":false,"given":"Francesca","family":"Scurtu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, 011132 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian Catalin","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology I, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Simionescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Dermatology I, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.mayocp.2017.02.015","article-title":"Incidence and Trends of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 2000 to 2010","volume":"92","author":"Muzic","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0190-9622(08)81509-5","article-title":"Nonmelanoma skin cancer in the United States: Incidence","volume":"30","author":"Miller","year":"1994","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/jso.23731","article-title":"The incidence and risk factors of metastasis for cutaneous squamous cell carcinoma\u2014Implications on the T-classification system","volume":"110","author":"Brougham","year":"2014","journal-title":"J. Surg. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Taccioli, F., Blessent, C.G., Paganelli, A., Fagioli, F., Chester, J.M., Kaleci, S., Costantini, M., Ferrari, B., Fiorentini, C., and De Santis, G. (2023). Delay in Cutaneous Squamous Cell Carcinoma Diagnosis Due to Interrupted Services Is Associated with Worse Prognoses and Modified Surgical Approaches. Cancers, 16.","DOI":"10.3390\/cancers16081469"},{"key":"ref_5","first-page":"687","article-title":"Trichilemmal carcinoma\u2014A rare cutaneous malignancy: Report of two cases","volume":"55","author":"Sajin","year":"2014","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4103\/0019-5154.143592","article-title":"Acantholytic Variant of Bowen\u2019s Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant","volume":"59","author":"Pai","year":"2014","journal-title":"Indian J. Dermatol."},{"key":"ref_7","unstructured":"WHO (2022). Classification of Female Genital Tumours and Tumours of the Urinary System and Male Genitals, International Agency for Research on Cancer. [5th ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.urology.2020.04.023","article-title":"An Overview of Penile and Scrotal Dermatoses","volume":"142","author":"Young","year":"2020","journal-title":"Urology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1346-8138.2005.tb00747.x","article-title":"Bowen\u2019s disease involving the urethra","volume":"32","author":"Shimizu","year":"2005","journal-title":"J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ad.2016.07.016","article-title":"Precancerous Skin Lesions. Prec\u00e1ncer cut\u00e1neo","volume":"108","author":"Malvehy","year":"2017","journal-title":"Actas Dermosifiliogr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/idoj.idoj_257_21","article-title":"Bowen\u2019s Disease","volume":"13","author":"Palaniappan","year":"2022","journal-title":"Indian Dermatol. Online J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4103\/2229-5178.142546","article-title":"Bowen\u2019s disease: An unusual clinical presentation","volume":"5","author":"Dandale","year":"2014","journal-title":"Indian Dermatol. Online J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/1756287211412657","article-title":"Diagnosis and management of premalignant penile lesions","volume":"3","author":"Shabbir","year":"2011","journal-title":"Ther. Adv. Urol."},{"key":"ref_14","first-page":"33","article-title":"Clinical, histological and therapeutic features of Bowen\u2019s disease","volume":"58","author":"Neagu","year":"2017","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/archderm.1997.03890460087010","article-title":"The molecular basis of nonmelanoma skin cancer: New understanding","volume":"133","author":"Grossman","year":"1997","journal-title":"Arch. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1590\/abd1806-4841.20176331","article-title":"Pigmented Bowen\u2019s disease associated with high-risk HPV simulating melanoma of the hand","volume":"92","author":"Lellis","year":"2017","journal-title":"An. Bras. Dermatol."},{"key":"ref_17","first-page":"594","article-title":"Bowen\u2019s Disease Associated With Two Human Papilloma Virus Types","volume":"55","author":"Eftekhari","year":"2017","journal-title":"Acta Med. Iran."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000335371","article-title":"High-risk human papillomavirus infection in Bowen\u2019s disease of the nail unit: Report of three cases and review of the literature","volume":"223","author":"Grundmeier","year":"2011","journal-title":"Dermatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0190-9622(92)70208-W","article-title":"Cutaneous Bowen\u2019s disease. An analysis of 1001 cases according to age, sex, and site","volume":"27","author":"Kossard","year":"1992","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/cup.14092","article-title":"Differentiating pagetoid Bowen disease from Paget disease on the nipple-areola complex: Two unique, challenging cases","volume":"48","author":"Barrutia","year":"2021","journal-title":"J. Cutan. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/ijd.13734","article-title":"What\u2019s new in dermoscopy of Bowen\u2019s disease: Two new dermoscopic signs and its differential diagnosis","volume":"56","author":"Yang","year":"2017","journal-title":"Int. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1001\/archdermatol.2011.155","article-title":"Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction: Results of a multicenter study by the International Dermoscopy Society (IDS)","volume":"147","author":"Blum","year":"2011","journal-title":"Arch. Dermatol."},{"key":"ref_23","first-page":"506","article-title":"Acral and Multicentric Pigmented Bowen\u2019s Disease in HIV-Positive Patients: Report on Two Unusual Cases","volume":"63","year":"2018","journal-title":"Indian J. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/cup.12610","article-title":"Orthokeratotic Bowen disease: A histopathologic, immunohistochemical and molecular study","volume":"43","author":"Idriss","year":"2016","journal-title":"J. Cutan. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/j.1365-2133.2004.05924.x","article-title":"Dermoscopy of Bowen\u2019s disease","volume":"150","author":"Zalaudek","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1590\/abd1806-4841.20142725","article-title":"Pigmented Bowen\u2019s disease","volume":"89","author":"Mota","year":"2014","journal-title":"An. Bras. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1097\/DAD.0000000000002293","article-title":"Bowen Disease Within a Circumscribed Palmar Hypokeratosis","volume":"44","author":"Requena","year":"2022","journal-title":"Am. J. Dermatopathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.ad.2016.02.017","article-title":"Treatment of Bowen Disease With Photodynamic Therapy and the Advantages of Sequential Topical Imiquimod. Tratamiento de la enfermedad de Bowen con terapia fotodin\u00e1mica y ventajas de la aplicaci\u00f3n secuencial de imiquimod t\u00f3pico","volume":"108","year":"2017","journal-title":"Actas Dermosifiliogr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1440-0960.1998.tb01250.x","article-title":"Treatment of cutaneous Bowen\u2019s disease with particular emphasis on the problem of lower leg lesions","volume":"39","author":"Ball","year":"1998","journal-title":"Australas. J. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2133.2006.07610.x","article-title":"Therapy Guidelines and Audit Subcommittee, British Association of Dermatologists. Guidelines for management of Bowen\u2019s disease: 2006 update","volume":"156","author":"Cox","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-0960.2004.00025.x","article-title":"Squamous cell carcinoma in situ of the skin: History, presentation, biology and treatment","volume":"45","author":"Arlette","year":"2004","journal-title":"Australas. J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/bjd\/ljac042","article-title":"British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma in situ (Bowen disease) 2022","volume":"188","author":"Sharma","year":"2023","journal-title":"Br. J. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pdpdt.2018.09.009","article-title":"Photodynamic therapy for Bowen\u2019s Disease (squamous cell carcinoma in situ) current review and update","volume":"24","author":"Okhovat","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e14817","DOI":"10.1111\/dth.14817","article-title":"The diagnostic value of p63, p16, and p53 immunohistochemistry in distinguishing seborrheic keratosis, actinic keratosis, and Bowen\u2019s disease","volume":"34","author":"Nasiri","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1684\/ejd.2023.4497","article-title":"Ultrastructural and morphological analysis during progression of Bowen disease reveals a complex interplay between hyperkeratosis, cytokeratin expression, host immunity and amyloid deposition","volume":"33","author":"Goto","year":"2023","journal-title":"Eur. J. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/ajcp\/aqz001","article-title":"Ki-67 and p16 Immunostaining Differentiates Pagetoid Bowen Disease From \u201cMicroclonal\u201d Seborrheic Keratosis","volume":"151","author":"Bahrani","year":"2019","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4103\/0378-6323.102359","article-title":"Practical immunohistochemistry of epithelial skin tumor","volume":"78","author":"Alhumaidi","year":"2012","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_38","first-page":"139","article-title":"Dyskeratose erythroplasiforme de la muqueuse vulvaire","volume":"29","author":"Hudelo","year":"1922","journal-title":"Bull. Soc. Franc. Dermatol. Syph."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/LGT.0000000000000049","article-title":"Evolution of terminology for human-papillomavirus-infection-related vulvar squamous intraepithelial lesions","volume":"19","author":"Wilkinson","year":"2015","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/AOG.0000000000001285","article-title":"The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of Vulvar Squamous Intraepithelial Lesions","volume":"127","author":"Bornstein","year":"2016","journal-title":"Obstet. Gynecol."},{"key":"ref_41","first-page":"807","article-title":"Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee","volume":"50","author":"Sideri","year":"2005","journal-title":"J. Reprod. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0002-9378(82)90398-2","article-title":"Intraepithelial squamous lesions of the vulva: Biologic and histologic criteria for the distinction of condylomas from vulvar intraepithelial neoplasia","volume":"144","author":"Crum","year":"1982","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/PGP.0b013e31826916c7","article-title":"The Lower Anogenital Squamous Terminology Standardization project for HPV-associated lesions: Background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology","volume":"32","author":"Darragh","year":"2013","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/01.pas.0000213291.96401.48","article-title":"The distribution of low risk and high-risk types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN)","volume":"30","author":"Srodon","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1097\/PAS.0b013e31804c9883","article-title":"Comment on the Article: Srodon M, Stoler MH, Baber GB; et al. The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN) Am J Surg Pathol. 2006;30:1513-1518","volume":"31","author":"Sideri","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ijc.33198","article-title":"Vulvar intraepithelial neoplasia: Incidence and long-term risk of vulvar squamous cell carcinoma","volume":"148","author":"Thuijs","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S0950268815002198","article-title":"Prophylactic HPV vaccination: Past, present, and future","volume":"144","author":"Castle","year":"2016","journal-title":"Epidemiol. Infect."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"768","DOI":"10.5858\/arpa.2018-0019-RS","article-title":"Differentiated Vulvar Intraepithelial Neoplasia: A Brief Review of Clinicopathologic Features","volume":"143","author":"Jin","year":"2019","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/01.AOG.0000210268.57527.a1","article-title":"Trends in the incidence of invasive and in situ vulvar carcinoma","volume":"107","author":"Judson","year":"2006","journal-title":"Obstet. Gynecol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00128360-199801000-00007","article-title":"Vulvar intraepithelial neoplasia: A synopsis of recent developments","volume":"2","author":"Colgan","year":"1998","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_51","first-page":"613","article-title":"Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women","volume":"45","author":"Joura","year":"2000","journal-title":"J. Reprod. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/aogs.14814","article-title":"Differentiated vulvar intraepithelial neoplasia long-term follow up and prognostic factors: An analysis of a large historical cohort","volume":"103","author":"Gallio","year":"2024","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/AOG.0000000000002736","article-title":"Human Papillomavirus Genotypes From Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age","volume":"132","author":"Garland","year":"2018","journal-title":"Obstet. Gynecol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"L\u00e9onard, B., Kridelka, F., Delbecque, K., Goffin, F., Demoulin, S., Doyen, J., and Delvenne, P. (2014). A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/480573"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/PAS.0b013e318263cda6","article-title":"Coexisting high-grade vulvar intraepithelial neoplasia (VIN) and condyloma acuminatum: Independent lesions due to different HPV types occurring in immunocompromised patients","volume":"37","author":"Maniar","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1158\/1055-9965.EPI-07-2922","article-title":"A systematic review of the prevalence and attribution of human papillomavirus types among cervical, vaginal, and vulvar precancers and cancers in the United States","volume":"17","author":"Insinga","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1086\/597071","article-title":"Natural history of genital warts: Analysis of the placebo arm of 2 randomized phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine","volume":"199","author":"Garland","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/jmv.21733","article-title":"Distribution of human papillomavirus types in the anogenital tract of females and males","volume":"82","author":"Barzon","year":"2010","journal-title":"J. Med. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2324709618758348","DOI":"10.1177\/2324709618758348","article-title":"Giant Condylomata Acuminata of Buschke-Lowenstein Associated with Paraneoplastic Hypercalcemia","volume":"6","author":"Venter","year":"2018","journal-title":"J. Investig. Med. High Impact Case Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1111\/pde.12617","article-title":"Combination Systemic Fluorouracil and Radiation for the Treatment of Recalcitrant Condyloma with Associated Squamous Cell Carcinoma in an Immunocompromised 15-Year-Old Girl","volume":"32","author":"Paul","year":"2015","journal-title":"Pediatr. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/1097-0142(19881015)62:8<1601::AID-CNCR2820620824>3.0.CO;2-9","article-title":"Multicentric intraepithelial neoplasia involving the vulva. Clinical features and association with human papillomavirus and herpes simplex virus","volume":"62","author":"Bornstein","year":"1988","journal-title":"Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.0004-8666.2002.00075.x","article-title":"High-grade vulval intraepithelial neoplasia (VIN 3): A retrospective analysis of patient characteristics, management, outcome and relationship to squamous cell carcinoma of the vulva 1989\u20131999","volume":"42","author":"Sykes","year":"2002","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/his.12034","article-title":"Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma","volume":"62","author":"Ordi","year":"2013","journal-title":"Histopathology"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Blas, M.M., Alva, I.E., Garcia, P.J., Carcamo, C., Montano, S.M., Mu\u00f1ante, R., and Zunt, J.R. (2012). Association between human papillomavirus and human T-lymphotropic virus in indigenous women from the Peruvian Amazon. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044240"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1007\/s12094-021-02739-x","article-title":"Analysis of related factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia","volume":"24","author":"Zhang","year":"2022","journal-title":"Clin. Transl. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Xu, M., and Wang, Y. (2024). Clinical characteristics, HPV involvement, and demographic risk factors in women with cervical intraepithelial neoplasia complicated by vaginal intraepithelial neoplasia. BMC Womens Health, 24.","DOI":"10.1186\/s12905-024-03030-1"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e29474","DOI":"10.1002\/jmv.29474","article-title":"Human papillomavirus genotyping in high-grade vaginal intraepithelial neoplasia: A multicentric Italian study","volume":"96","author":"Preti","year":"2024","journal-title":"J. Med. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/gyno.1995.1046","article-title":"Vulvar intraepithelial neoplasia III: A viral disease of undetermined progressive potential","volume":"56","author":"Junge","year":"1995","journal-title":"Gynecol. Oncol."},{"key":"ref_69","first-page":"V12170931","article-title":"Vulvar intraepithelial neoplasia","volume":"180","author":"Vorbeck","year":"2018","journal-title":"Ugeskr. L\u00e6ger"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.bpobgyn.2014.07.010","article-title":"Vulvar intraepithelial neoplasia","volume":"28","author":"Preti","year":"2014","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Scurtu, L.G., Jinga, V., and Simionescu, O. (2022). Fascinating Molecular and Immune Escape Mechanisms in the Treatment of STIs (Syphilis, Gonorrhea, Chlamydia, and Herpes Simplex). Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073550"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Jain, M., Yadav, D., Jarouliya, U., Chavda, V., Yadav, A.K., Chaurasia, B., and Song, M. (2023). Epidemiology, Molecular Pathogenesis, Immuno-Pathogenesis, Immune Escape Mechanisms and Vaccine Evaluation for HPV-Associated Carcinogenesis. Pathogens, 12.","DOI":"10.3390\/pathogens12121380"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s10156-012-0485-5","article-title":"Immune responses against human papillomavirus (hpv) infection and evasion of host defense in cervical cancer","volume":"18","author":"Sasagawa","year":"2012","journal-title":"J. Infect. Chemother."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1158\/0008-5472.CAN-10-2193","article-title":"Molecular pathobiology of human cervical high-grade lesions: Paracrine stat3 activation in tumor-instructed myeloid cells drives local mmp-9 expression","volume":"71","author":"Pahne","year":"2011","journal-title":"Cancer Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/LGT.0b013e318196bd23","article-title":"Vulvar Intraepithelial Neoplasia 3 in Women Less than 35 Years","volume":"13","author":"Kesterson","year":"2009","journal-title":"J. Low. Genit. Tract. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0733-8635(18)30335-8","article-title":"Normal histology and nomenclature of the vulva, and malignant neoplasms, including VIN","volume":"10","author":"Wilkinson","year":"1992","journal-title":"Dermatol. Clin."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/01.pgp.0000236944.36593.d0","article-title":"Progression of simplex (differentiated) vulvar intraepithelial neoplasia to invasive squamous cell carcinoma: A prospective case study confirming its precursor role in the pathogenesis of vulvar cancer","volume":"26","author":"Roma","year":"2007","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_78","unstructured":"Ayala, M., and Fatehi, M. (2024). Vulvar Intraepithelial Neoplasia. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ygyno.2014.11.002","article-title":"Genetic and epigenetic changes in vulvar squamous cell carcinoma and its precursor lesions: A review of the current literature","volume":"136","author":"Trietsch","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.1158\/1078-0432.CCR-17-1302","article-title":"Genomic Characterization of Vulvar (Pre)cancers Identifies Distinct Molecular Subtypes with Prognostic Significance","volume":"23","author":"Nooij","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/LGT.0000000000000662","article-title":"A Systematic Review of Risk Factors for Development, Recurrence, and Progression of Vulvar Intraepithelial Neoplasia","volume":"26","author":"Jamieson","year":"2022","journal-title":"J. Low. Genit. Tract. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.pathol.2016.02.015","article-title":"Squamous precursor lesions of the vulva: Current classification and diagnostic challenges","volume":"48","author":"Hoang","year":"2016","journal-title":"Pathology"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Kesi\u0107, V., Vieira-Baptista, P., and Stockdale, C.K. (2022). Early Diagnostics of Vulvar Intraepithelial Neoplasia. Cancers, 14.","DOI":"10.3390\/cancers14071822"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/LGT.0b013e31826a38f3","article-title":"Pigmented vulvar lesions\u2014A pathology review of lesions that are not melanoma","volume":"17","author":"Heller","year":"2013","journal-title":"J. Low. Genit. Tract. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"169","DOI":"10.5468\/ogs.23274","article-title":"Vulval premalignant lesions: A review article","volume":"67","author":"Gupta","year":"2024","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Dumitru, A.V., \u021a\u0103poi, D.A., Costache, M., Ciongariu, A.M., Ionescu, A.I., Liscu, H.D., Alius, C., Tampa, M., Marin, A., and Furtunescu, A.R. (2024). Metastatic Nodular Melanoma with Angiosarcomatous Transdifferentiation-A Case Report and Review of the Literature. Diagnostics, 14.","DOI":"10.3390\/diagnostics14131323"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00404-015-3666-5","article-title":"Colposcopic acetowhitening of vulvar lesion: A validity study","volume":"292","author":"Santoso","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_88","first-page":"e2023269","article-title":"Assessment of Vulvar Intraepithelial Neoplasia (VIN) Grades Based on Dermoscopic Features: A Diagnostic Study","volume":"13","author":"Magnaterra","year":"2023","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/bjd.14796","article-title":"Dermoscopic findings of vulvar intraepithelial neoplasia: A series of four cases","volume":"176","author":"Barisani","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/cdr.cdr_82_21","article-title":"Dermoscopic Aid in Diagnosing Vulval Intraepithelial Neoplasia","volume":"7","author":"Rao","year":"2023","journal-title":"Clin. Dermatol. Rev."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2133.2010.10043.x","article-title":"Features of pigmented vulval lesions on dermoscopy","volume":"164","author":"Julien","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/bjd.14300","article-title":"Clinical and dermoscopic characteristics of extramammary Paget disease: A study of 35 cases","volume":"174","author":"Mun","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000366539","article-title":"Dermoscopy of actinic keratosis, intraepidermal carcinoma and squamous cell carcinoma","volume":"46","author":"Zalaudek","year":"2015","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jaad.2009.06.008","article-title":"Dermatoscopy of pigmented Bowen\u2019s disease","volume":"62","author":"Cameron","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_95","unstructured":"Malvehy, J., and Puig, S. (2002). Dermoscopic findings of pigmented lesions of the mucosae. Principles of Dermoscopy, Cage Editors."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00000478-200003000-00013","article-title":"Vulvar intraepithelial neoplasia of the simplex (differentiated) type: A clinicopathologic study including analysis of HPV and p53 expression","volume":"24","author":"Yang","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.pgp.0000189238.19027.df","article-title":"Pathologic audit of 164 consecutive cases of vulvar intraepithelial neoplasia","volume":"25","author":"Scurry","year":"2006","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/LGT.0000000000000572","article-title":"ISSVD Difficult Pathologic Diagnoses Committee. Diagnostic Criteria for Differentiated Vulvar Intraepithelial Neoplasia and Vulvar Aberrant Maturation","volume":"25","author":"Heller","year":"2021","journal-title":"J. Low. Genit. Tract. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1097\/PAS.0000000000000124","article-title":"Histologic and immunohistochemical assessment of penile carcinomas in a North American population","volume":"38","author":"Mentrikoski","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/106689690100900204","article-title":"Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection","volume":"9","author":"Cubilla","year":"2001","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.urology.2010.03.003","article-title":"Epidemiology and natural history of penile cancer","volume":"76","author":"Ferreira","year":"2010","journal-title":"Urology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/jcp.2008.063149","article-title":"Human papillomavirus prevalence and type distribution in penile carcinoma","volume":"62","author":"Bruni","year":"2009","journal-title":"J. Clin. Pathol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/modpathol.3800371","article-title":"Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: A report of 89 cases","volume":"18","author":"Velazquez","year":"2005","journal-title":"Mod. Pathol."},{"key":"ref_104","first-page":"241","article-title":"Precancerous dermatoses: A study of 2 cases of chronic atypical proliferation","volume":"30","author":"Bowen","year":"1912","journal-title":"J. Cutan. Dis. Syph."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Epstein, J.H., Cubilla, A.L., and Humphrey, P.A. (2011). Tumors of the prostate gland, seminal vesicles, penis and scrotum. Atlas of Tumor Pathology, Armed Forces Institute of Pathology.","DOI":"10.55418\/9781933477145"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1053\/j.semdp.2011.08.009","article-title":"Histologic classification of penile intraepithelial neoplasia","volume":"29","author":"Velazquez","year":"2012","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_107","unstructured":"Chamli, A., and Zaouak, A. (2022). Bowenoid Papulosis. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2340\/00015555-3083","article-title":"Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000\u20132012","volume":"99","author":"Kristiansen","year":"2019","journal-title":"Acta Derm. Venereol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Griffiths, C., Barker, J., Bleiker, T., Chalmers, R., and Creamer, D. (2016). Dermatoses of the Male Genitalia. Rook\u2019s Textbook of Dermatology, John Wiley & Sons Inc.. [9th ed.].","DOI":"10.1002\/9781118441213"},{"key":"ref_110","first-page":"90","article-title":"The acetic acid test in evaluation of subclinical genital papillomavirus infection: A comparative study on penoscopy, histopathology, virology and scanning electron microscopy findings","volume":"68","author":"Hedblad","year":"1992","journal-title":"Genitourin. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/ijstd.IJSTD_106_17","article-title":"Premalignant male genital dermatoses","volume":"40","author":"Singhal","year":"2019","journal-title":"Indian J. Sex. Transm. Dis. AIDS"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5021\/ad.2016.28.1.40","article-title":"Dermatoses of the Glans Penis in Korea: A 10-Year Single Center Experience","volume":"28","author":"You","year":"2016","journal-title":"Ann. Dermatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00105-013-2664-4","article-title":"Unklare Hautver\u00e4nderung an der Glans penis f\u00fchrt zu unterschiedlichen dermatoskopischen Diagnosen [Unclear clinical change on the glans penis leads to different dermoscopic diagnoses]","volume":"64","author":"Blum","year":"2013","journal-title":"Hautarzt"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"\u021a\u0103poi, D.A., Gheorghi\u0219an-G\u0103l\u0103\u021beanu, A.A., Dumitru, A.V., Ciongariu, A.M., Furtunescu, A.R., Marin, A., and Costache, M. (2023). Primary Undifferentiated\/Dedifferentiated Cutaneous Melanomas-A Review on Histological, Immunohistochemical, and Molecular Features with Emphasis on Prognosis and Treatment. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24129985"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Giuglea, C., Marin, A., Gavrila, I., Paunescu, A., Dobrete, N.A., and Marinescu, S.A. (2023). Basal Cell Carcinoma-A Retrospective Descriptive Study Integrated in Current Literature. Life, 13.","DOI":"10.3390\/life13030832"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1590\/abd1806-4841.20164595","article-title":"Erythroplasia of Queyrat treated with topical 5-fluorouracil","volume":"91","author":"Alves","year":"2016","journal-title":"Bras Dermatol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.4081\/cp.2012.e63","article-title":"Erythroplasia of Queyrat","volume":"2","author":"Fanning","year":"2012","journal-title":"Clin. Pract."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Scurtu, L.G., and Simionescu, O. (2021). Soluble Factors and Receptors Involved in Skin Innate Immunity\u2014What Do We Know So Far?. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121795"},{"key":"ref_119","first-page":"1301","article-title":"Genital Lichen Planus in Males: Clinical, Laboratory, and Histological Aspects of 7 Cases","volume":"6","author":"Tamanini","year":"2022","journal-title":"Clin. Case Rep. Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42047-019-0053-8","article-title":"Penile squamous cell carcinoma and lichen planus","volume":"3","author":"Alencar","year":"2020","journal-title":"Surg. Exp. Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/jdv.14488","article-title":"The diagnosis and management of male genital lichen sclerosus: A retrospective review of 301 patients","volume":"32","author":"Kravvas","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Vladulescu, D., Scurtu, L.G., Simionescu, A.A., Scurtu, F., Popescu, M.I., and Simionescu, O. (2023). Platelet-Rich Plasma (PRP) in Dermatology: Cellular and Molecular Mechanisms of Action. Biomedicines, 12.","DOI":"10.3390\/biomedicines12010007"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"De Luca, D.A., Papara, C., Vorobyev, A., Staiger, H., Bieber, K., Tha\u00e7i, D., and Ludwig, R.J. (2023). Lichen sclerosus: The 2023 update. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1106318"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1111\/jdv.18328","article-title":"Pseudoepitheliomatous keratotic and micaceous balanitis: A series of eight cases","volume":"36","author":"Spencer","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3322\/caac.21354","article-title":"Pathophysiological basis of human papillomavirus in penile cancer: Key to prevention and delivery of more effective therapies","volume":"66","author":"Spiess","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.eururo.2015.05.032","article-title":"Genital HPV infection progression to external genital lesions: The HIM Study","volume":"69","author":"Sudenga","year":"2015","journal-title":"Eur. Urol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1111\/jdv.13538","article-title":"Dermoscopy of Zoon\u2019s plasma cell balanitis","volume":"30","author":"Errichetti","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1111\/ajd.12981","article-title":"Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat","volume":"60","author":"Chan","year":"2019","journal-title":"Australas. J. Dermatol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.jaad.2009.04.012","article-title":"Videodermatoscopy enhances diagnostic capability in psoriatic balanitis","volume":"61","author":"Lacarrubba","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41379-022-01020-y","article-title":"Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: A North American series","volume":"35","author":"Spieker","year":"2022","journal-title":"Mod. Pathol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.urolonc.2020.09.010","article-title":"Evolving insights into penile cancer pathology and the eighth edition of the AJCC TNM staging system","volume":"40","author":"Sanchez","year":"2022","journal-title":"Urol. Oncol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.humpath.2011.07.025","article-title":"Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: A pathological study of 139 lesions in 121 patients","volume":"43","author":"Chaux","year":"2012","journal-title":"Hum. Pathol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/PAS.0b013e3181cdad23","article-title":"Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and\/or basaloid features: A study of 141 cases evaluating a new nomenclature","volume":"34","author":"Chaux","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_134","first-page":"477","article-title":"Treatment of Arsenic-Induced Bowen\u2019s Disease with Topical 5-Fluorouracil","volume":"18","author":"Verhave","year":"2019","journal-title":"J. Drugs Dermatol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1365-4632.2007.03200.x","article-title":"Successful treatment of perianal Bowen\u2019s disease with imiquimod","volume":"46","author":"Hoedemaker","year":"2007","journal-title":"Int. J. Dermatol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"103201","DOI":"10.1016\/j.pdpdt.2022.103201","article-title":"Successful treatment of extremely large Bowen\u2019s disease lesion by topical photodynamic therapy and imiquimod: Using optical coherence tomography to detect early recurrence loci and validate the cure","volume":"41","author":"Wang","year":"2023","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ygyno.2005.08.012","article-title":"Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO2 laser vaporization, photodynamic therapy, excision and vulvectomy","volume":"100","author":"Hillemanns","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1097\/AOG.0000000000002311","article-title":"Topical 5-Fluorouracil for Women With High-Grade Vaginal Intraepithelial Neoplasia","volume":"130","author":"Fiascone","year":"2017","journal-title":"Obstet. Gynecol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/ijgc-2021-003262","article-title":"The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) consensus statements on pre-invasive vulvar lesions","volume":"32","author":"Preti","year":"2022","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"928568","DOI":"10.3389\/fonc.2022.928568","article-title":"Recommendations for the treatment of vulvar cancer in settings with limited resources: Report from the International Gynecological Cancer Society consensus meeting","volume":"12","author":"Maluf","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1158\/1078-0432.CCR-05-0616","article-title":"Detection of human papillomavirus (HPV) 16-specific CD4+ T-cell immunity in patients with persistent HPV16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment","volume":"11","author":"Kwappenberg","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_142","first-page":"CD011837","article-title":"Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia","volume":"2016","author":"Lawrie","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1046\/j.1365-2133.2002.05019.x","article-title":"Penile intraepithelial neoplasia: Clinical spectrum and treatment of 35 cases","volume":"147","author":"Porter","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Scurtu, L.G., Petrica, M., Grigore, M., Avram, A., Popescu, I., and Simionescu, O. (2022). A Conservative Combined Laser Cryoimmunotherapy Treatment vs. Surgical Excision for Basal Cell Carcinoma. J. Clin. Med., 11.","DOI":"10.3390\/jcm11123439"},{"key":"ref_145","first-page":"1454","article-title":"Erythroplasia of Queyrat with urethral involvement: Treatment with carbon dioxide laser vaporization","volume":"31","author":"Vieira","year":"2005","journal-title":"Dermatol. Surg."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.euf.2021.04.026","article-title":"Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review","volume":"8","author":"Issa","year":"2022","journal-title":"Eur. Urol. Focus."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1080\/09546634.2020.1800574","article-title":"The management of penile intraepithelial neoplasia (PeIN): Clinical and histological features and treatment of 345 patients and a review of the literature","volume":"33","author":"Kravvas","year":"2022","journal-title":"J. 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