{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:15:42Z","timestamp":1781792142539,"version":"3.54.5"},"reference-count":36,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Celiac disease (CeD) is an enteropathy caused by the complex interaction between genetic, environmental, and individual immunological factors. Besides the hallmark of intestinal mucosal damage, CeD is a systemic disorder extending beyond the gastrointestinal tract and impacting various other organs, causing extraintestinal and atypical symptoms. The association between CeD and liver damage has been classified into three main categories: mild and asymptomatic liver injury, autoimmune liver injury, and liver failure. We present a case of severe liver damage with cirrhotic evolution in an obese 12-year-old boy who had been admitted due to generalized jaundice and localized abdominal pain in the right hypochondrium. In the course of investigating the etiology of severe liver disease, toxic, infectious, metabolic, obstructive, and genetic causes were excluded. Despite the patient\u2019s obesity, a diagnosis of CeD was established, and in accordance with autoimmune hepatitis (AIH) criteria, the patient was diagnosed with autoantibody-negative AIH associated to CeD.<\/jats:p>","DOI":"10.3390\/diagnostics14161832","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T04:26:57Z","timestamp":1724300817000},"page":"1832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severe Liver Damage in an Obese Patient: Onset of Celiac Disease or Overlap Syndrome?"],"prefix":"10.3390","volume":"14","author":[{"given":"Gabriela","family":"Ghiga","sequence":"first","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Otilia","family":"Boca","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7859-840X","authenticated-orcid":false,"given":"Elena","family":"Cojocaru","sequence":"additional","affiliation":[{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"},{"name":"Department of Morphofunctional Sciences, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-7425","authenticated-orcid":false,"given":"Iuliana Magdalena","family":"St\u00e2rcea","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-8011","authenticated-orcid":false,"given":"Elena","family":"\u021aarc\u0103","sequence":"additional","affiliation":[{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"},{"name":"Department of Pediatric Surgery, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Scurtu","sequence":"additional","affiliation":[{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Adriana","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana","family":"Ioniuc","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela Camelia","family":"T\u00eernovanu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"\u201cCuza Voda\u201d Obstetrics-Gynecology Clinic Hospital, 700038 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-7610","authenticated-orcid":false,"given":"Laura Mihaela","family":"Trandafir","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, Faculty of Medicine, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Iasi, Romania"},{"name":"\u201cSaint Mary\u201d Emergency Hospital for Children, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.3748\/wjg.v28.i32.4493","article-title":"Who to screen and how to screen for celiac disease","volume":"28","author":"Singh","year":"2022","journal-title":"World J. 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