{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:32Z","timestamp":1791158432547,"version":"4.1.0"},"reference-count":85,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union","award":["PNRR-MR1-2022-12376512"],"award-info":[{"award-number":["PNRR-MR1-2022-12376512"]}]},{"name":"European Union","award":["CUP: H63C22000470006"],"award-info":[{"award-number":["CUP: H63C22000470006"]}]},{"name":"Unione europea\u2014NextGenerationEU within the Program","award":["PNRR-MR1-2022-12376512"],"award-info":[{"award-number":["PNRR-MR1-2022-12376512"]}]},{"name":"Unione europea\u2014NextGenerationEU within the Program","award":["CUP: H63C22000470006"],"award-info":[{"award-number":["CUP: H63C22000470006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Craniosynostoses (CRS) are caused by the premature fusion of one or more cranial sutures, with isolated nonsyndromic CRS accounting for most of the clinical manifestations. Such premature suture fusion impacts both skull and brain morphology and involves regions far beyond the immediate area of fusion. The combined use of different neuroimaging tools allows for an accurate depiction of the most prominent clinical\u2013radiological features in nonsyndromic CRS but can also contribute to a deeper investigation of more subtle alterations in the underlying nervous tissue organization that may impact normal brain development. This review paper aims to provide a comprehensive framework for a better understanding of the present and future potential applications of neuroimaging techniques for evaluating nonsyndromic CRS, highlighting strategies for optimizing their use in clinical practice and offering an overview of the most relevant technological advancements in terms of diagnostic performance, radiation exposure, and cost-effectiveness.<\/jats:p>","DOI":"10.3390\/diagnostics14171842","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:53:19Z","timestamp":1724417599000},"page":"1842","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neuroimaging in Nonsyndromic Craniosynostosis: Key Concepts to Unlock Innovation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2256-7281","authenticated-orcid":false,"given":"Camilla","family":"Russo","sequence":"first","affiliation":[{"name":"Neuroradiology Unit, Department of Pediatric Neurosciences, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Aliberti","sequence":"additional","affiliation":[{"name":"Cranio-Maxillo-Facial Surgery Unit, Department of Pediatric Neurosciences, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula Pia","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Unit, Department of Pediatric Neurosciences, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, 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