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(Dentists of Helsinki Region Association)","award":["No. T62664","Y1014SULE1","Y1014SL018","Y1014SL017","TYH2019319","TYH2018229","TYH2017251","TYH2016251","TYH2020337","TYH2022225","Y2519SU010"],"award-info":[{"award-number":["No. T62664","Y1014SULE1","Y1014SL018","Y1014SL017","TYH2019319","TYH2018229","TYH2017251","TYH2016251","TYH2020337","TYH2022225","Y2519SU010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Periodontal tissue damage is mainly caused by the active form of collagenolytic matrix metalloproteinase-8, aMMP-8, the concentration of which in the mouth rinse can be measured with a mouth rinse chairside-test. The mouth rinse chair side test can be used to identify adolescents with a risk of periodontitis. Methods: The data were collected at the Kotka Health Centre (2004\u20132005, N = 501 and 2014\u20132015, N = 47) and at the H\u00e4meenlinna Health Centre (2017\u20132018, N = 125) consisting of adolescents aged 14\u201317. They underwent a complete periodontal examination, and some were subjected to the aMMP-8-test. Results: We identified bacterial plaques in combination with increased bleeding on probing (BOP), elevated aMMP-8 concentration, smoking and male sex as the main risk factors for initial periodontitis. Approximately 10% of adolescents had subclinical periodontitis, they were not periodontally healthy, but also not sick. They may not develop periodontitis, but they are at the risk. The aMMP-8 test positivity had a stronger association with initial periodontitis than BOP. Conclusions: In addition to identifying risk factors, these adolescents need individual prevention and, if necessary, early treatment. For the periodontal health biomarker aMMP-8, test negativity ([-], \u226420 ng\/mL) should be sought.<\/jats:p>","DOI":"10.3390\/diagnostics14171850","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T01:48:49Z","timestamp":1724636929000},"page":"1850","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevention of Initial Periodontitis Is an Investment in the Future"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3252-192X","authenticated-orcid":false,"given":"Anna Maria","family":"Heikkinen","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology, University of Tampere, 33100 Tampere, Finland"},{"name":"Wellbeing Services County of Pirkanmaa, 33400 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-8547","authenticated-orcid":false,"given":"Teija","family":"Raivisto","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases and Public Health, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-5299","authenticated-orcid":false,"given":"Ismo Tapani","family":"R\u00e4is\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases and Public Health, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases and Public Health, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"},{"name":"Department of Dental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/prd.12313","article-title":"New developments in neutrophil biology and periodontitis","volume":"82","author":"Hajishengallis","year":"2020","journal-title":"Periodontology 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s00784-019-02915-y","article-title":"Matrix metalloproteinases and inhibitors in dentistry","volume":"23","author":"Boelen","year":"2019","journal-title":"Clin. 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