{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:04:51Z","timestamp":1792829091494,"version":"4.5.0"},"reference-count":27,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>This multicenter retrospective study evaluated the diagnostic performance of a deep learning (DL)-based application for detecting, classifying, and highlighting suspected aortic dissections (ADs) on chest and thoraco-abdominal CT angiography (CTA) scans. CTA scans from over 200 U.S. and European cities acquired on 52 scanner models from six manufacturers were retrospectively collected and processed by CINA-CHEST (AD) (Avicenna.AI, La Ciotat, France) device. The diagnostic performance of the device was compared with the ground truth established by the majority agreement of three U.S. board-certified radiologists. Furthermore, the DL algorithm\u2019s time to notification was evaluated to demonstrate clinical effectiveness. The study included 1303 CTAs (mean age 58.8 \u00b1 16.4 years old, 46.7% male, 10.5% positive). The device demonstrated a sensitivity of 94.2% [95% CI: 88.8\u201397.5%] and a specificity of 97.3% [95% CI: 96.2\u201398.1%]. The application classified positive cases by the AD type with an accuracy of 99.5% [95% CI: 98.9\u201399.8%] for type A and 97.5 [95% CI: 96.4\u201398.3%] for type B. The application did not miss any type A cases. The device flagged 32 cases incorrectly, primarily due to acquisition artefacts and aortic pathologies mimicking AD. The mean time to process and notify of potential AD cases was 27.9 \u00b1 8.7 s. This deep learning-based application demonstrated a strong performance in detecting and classifying aortic dissection cases, potentially enabling faster triage of these urgent cases in clinical settings.<\/jats:p>","DOI":"10.3390\/diagnostics14171877","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T06:19:01Z","timestamp":1724739541000},"page":"1877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic Performance of a Deep Learning-Powered Application for Aortic Dissection Triage Prioritization and Classification"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-4218","authenticated-orcid":false,"given":"Vladimir","family":"Laletin","sequence":"first","affiliation":[{"name":"Avicenna.AI, 375 Avenue du Mistral, 13600 La Ciotat, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-6782","authenticated-orcid":false,"given":"Angela","family":"Ayobi","sequence":"additional","affiliation":[{"name":"Avicenna.AI, 375 Avenue du Mistral, 13600 La Ciotat, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-7865","authenticated-orcid":false,"given":"Peter D.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, University of California Irvine, Irvine, CA 92697, USA"},{"name":"Center for Artificial Intelligence in Diagnostic Medicine, University of California Irvine, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, University of California Irvine, Irvine, CA 92697, USA"},{"name":"Center for Artificial Intelligence in Diagnostic Medicine, University of California Irvine, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Soun","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, University of California Irvine, Irvine, CA 92697, USA"},{"name":"Center for Artificial Intelligence in Diagnostic Medicine, University of California Irvine, Irvine, CA 92697, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline C.","family":"Junn","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Science, Emory University Hospital, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Scudeler","sequence":"additional","affiliation":[{"name":"Avicenna.AI, 375 Avenue du Mistral, 13600 La Ciotat, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Quenet","sequence":"additional","affiliation":[{"name":"Avicenna.AI, 375 Avenue du Mistral, 13600 La Ciotat, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7755-7356","authenticated-orcid":false,"given":"Maxime","family":"Tassy","sequence":"additional","affiliation":[{"name":"Avicenna.AI, 375 Avenue du Mistral, 13600 La Ciotat, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2943-3460","authenticated-orcid":false,"given":"Christophe","family":"Avare","sequence":"additional","affiliation":[{"name":"Avicenna.AI, 375 Avenue du Mistral, 13600 La Ciotat, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Roca-Sogorb","sequence":"additional","affiliation":[{"name":"Avicenna.AI, 375 Avenue du Mistral, 13600 La Ciotat, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-172X","authenticated-orcid":false,"given":"Yasmina","family":"Chaibi","sequence":"additional","affiliation":[{"name":"Avicenna.AI, 375 Avenue du Mistral, 13600 La Ciotat, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0733-8651(05)70105-3","article-title":"Natural History, Pathogenesis, and Etiology of Thoracic Aortic Aneurysms and Dissections","volume":"17","author":"Coady","year":"1999","journal-title":"Cardiol. 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