{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:04:52Z","timestamp":1782216292131,"version":"3.54.5"},"reference-count":144,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Spaceflight-Associated Neuro-Ocular Syndrome (SANS) is a complex pathology threatening the health of astronauts, with incompletely understood causes and no current specific functional diagnostic or screening test. We investigated the use of the differential performance of the visual system (central vs. perimacular visual function) as a candidate marker of SANS-related pathology in a ground-based microgravity analogue. Methods: We used a simple reaction time (SRT) task to visual stimuli, presented in the central and perimacular field of view, as a measure of the overall performance of the visual function, during acute settings (first 10 min) of vertical, bed rest (BR), \u22126\u00b0, and \u221215\u00b0 head-down tilt (HDT) presentations in healthy participants (n = 8). We built dose\u2013response models linking the gravitational component to SRT distribution parameters in the central vs. perimacular areas. Results: Acute exposure to microgravity induces detectable changes between SRT distributions in the perimacular vs. central retina (increased mean, standard deviation, and tau component of the ex-Gaussian function) in HDT compared with vertical presentation. Conclusions: Functional testing of the perimacular retina might be beneficial for the earlier detection of SANS-related ailments in addition to regular testing of the central vision. Future diagnostic tests should consider the investigation of the extra-macular areas, particularly towards the optic disc.<\/jats:p>","DOI":"10.3390\/diagnostics14171918","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T06:46:29Z","timestamp":1725000389000},"page":"1918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differential Functional Changes in Visual Performance during Acute Exposure to Microgravity Analogue and Their Potential Links with Spaceflight-Associated Neuro-Ocular Syndrome"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-1789","authenticated-orcid":false,"given":"Adrian","family":"Iftime","sequence":"first","affiliation":[{"name":"Biophysics Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8235-4501","authenticated-orcid":false,"given":"Ioana Teodora","family":"Tofolean","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Clinical Emergency Eye Hospital, 010464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Pintilie","sequence":"additional","affiliation":[{"name":"Biophysics Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8003-0442","authenticated-orcid":false,"given":"Octavian","family":"C\u0103linescu","sequence":"additional","affiliation":[{"name":"Biophysics Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4678-9655","authenticated-orcid":false,"given":"Stefan","family":"Busnatu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Medicine and Pharmacy \u201cCarol Davila\u201d, Emergency Hospital \u201cBagdasar-Arseni\u201d, 050474 Bucharest, Romania"},{"name":"Center for Innovation and eHealth, Carol Davila University of Medicine and Pharmacy, 010451 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Raluca","family":"Papacocea","sequence":"additional","affiliation":[{"name":"Center for Innovation and eHealth, Carol Davila University of Medicine and Pharmacy, 010451 Bucharest, Romania"},{"name":"Physiology III Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Krittanawong, C., Singh, N.K., Scheuring, R.A., Urquieta, E., Bershad, E.M., Macaulay, T.R., Kaplin, S., Dunn, C., Kry, S.F., and Russomano, T. 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