{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T15:30:30Z","timestamp":1782055830860,"version":"3.54.5"},"reference-count":14,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Hematology Association","award":["PN-IV-P8-8.3-ROMD-2023-0036"],"award-info":[{"award-number":["PN-IV-P8-8.3-ROMD-2023-0036"]}]},{"name":"European Hematology Association","award":["PNRR\/2023\/C9\/MCID\/I8"],"award-info":[{"award-number":["PNRR\/2023\/C9\/MCID\/I8"]}]},{"name":"Romanian Research Ministry","award":["PN-IV-P8-8.3-ROMD-2023-0036"],"award-info":[{"award-number":["PN-IV-P8-8.3-ROMD-2023-0036"]}]},{"name":"Romanian Research Ministry","award":["PNRR\/2023\/C9\/MCID\/I8"],"award-info":[{"award-number":["PNRR\/2023\/C9\/MCID\/I8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Capillary leak syndrome is a rare complication of cancer, particularly of hematologic malignancies. The syndrome was first described as an idiopathic entity; however, increasingly, more cases are being reported in association with cancers and other conditions. Diagnosis stems from the recognition of the double paradox, consisting of severe generalized oedema and hypotension, accompanied by hallmark laboratory modifications. Concurrent conditions in patients with malignancies can alter laboratory findings and make the diagnosis a challenge. This report presents the case of a patient with capillary leak syndrome and an atypical presentation, with generalized skin rash and transcutaneous exudation occurring concurrently with anaplastic large T cell lymphoma, macrophage activation syndrome, and cytopenias. Symptom-specific treatment with diuretics and albumin was ineffective in the case of our patient; however, the CLS remitted promptly with cancer-specific therapy. No treatment has proved to be generally effective against CLS up to date, as is the case for this patient. Thus, the rapid recognition of cancer-associated capillary leak syndrome and the initiation of cancer-specific treatment proves to be the better approach and is key to avoiding unnecessary delays and ineffective treatments targeted specifically at CLS.<\/jats:p>","DOI":"10.3390\/diagnostics14171924","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T06:51:17Z","timestamp":1725259877000},"page":"1924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Capillary Leak Syndrome Associated with Anaplastic T Cell Lymphoma and Transcutaneous Exudation: An Unusual Presentation"],"prefix":"10.3390","volume":"14","author":[{"given":"Radu Andrei","family":"Tomai","sequence":"first","affiliation":[{"name":"Department of Haematology, \u201cIon Chiricuta\u201d Institute of Oncology, 34\u201336 Republicii Street, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Oancea","sequence":"additional","affiliation":[{"name":"Department of Haematology, \u201cIon Chiricuta\u201d Institute of Oncology, 34\u201336 Republicii Street, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-1519","authenticated-orcid":false,"given":"Ciprian","family":"Tomuleasa","sequence":"additional","affiliation":[{"name":"Department of Haematology, \u201cIon Chiricuta\u201d Institute of Oncology, 34\u201336 Republicii Street, 400015 Cluj-Napoca, Romania"},{"name":"Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400124 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-265X","authenticated-orcid":false,"given":"Delia","family":"Dima","sequence":"additional","affiliation":[{"name":"Department of Haematology, \u201cIon Chiricuta\u201d Institute of Oncology, 34\u201336 Republicii Street, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0002-9343(60)90018-8","article-title":"Cyclical edema and shock due to increased capillary permeability","volume":"29","author":"Clarkson","year":"1960","journal-title":"Am. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.kint.2016.11.029","article-title":"Capillary leak syndrome: Etiologies, pathophysiology, and management","volume":"92","author":"Siddall","year":"2017","journal-title":"Kidney Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.revmed.2021.05.012","article-title":"Capillary leak syndrome: State of the art in 2021","volume":"42","author":"Bichon","year":"2021","journal-title":"Rev. Med. Interne"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.7326\/0003-4819-153-2-201007200-00005","article-title":"Narrative Review: The Systemic Capillary Leak Syndrome","volume":"153","author":"Druey","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"ref_5","first-page":"1000213","article-title":"Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease)","volume":"5","author":"Xie","year":"2014","journal-title":"J. Clin. Cell. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.semarthrit.2016.08.001","article-title":"Systemic capillary leak syndrome and autoimmune diseases: A case series","volume":"46","author":"Guffroy","year":"2017","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Shin, J.I., Lee, K.H., Lee, I.R., Oh, J.H., Kim, D.W., Shin, J.W., Eo, T.S., Kronbichler, A., Eisenhut, M., and Van der Vliet, H.J. (2018). Systemic Capillary Leak Syndrome (Clarkson Syndrome) in Cancer Patients: A Systematic Review. J. Clin. Med., 7.","DOI":"10.3390\/jcm7110418"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1182\/blood-2011-08-375816","article-title":"Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)","volume":"119","author":"Xie","year":"2012","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.4065\/mcp.2010.0159","article-title":"Idiopathic Systemic Capillary Leak Syndrome (Clarkson\u2019s Disease): The Mayo Clinic Experience","volume":"85","author":"Kamal","year":"2010","journal-title":"Mayo Clin. Proc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.ekir.2022.02.014","article-title":"Anticancer Drug-Induced Capillary Leak Syndrome","volume":"7","author":"Izzedine","year":"2022","journal-title":"Kidney Int. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41409-022-01562-4","article-title":"Profile of capillary-leak syndrome in patients received chimeric antigen receptor T cell therapy","volume":"57","author":"Feng","year":"2022","journal-title":"Bone Marrow Transplant."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.21037\/jeccm-22-22","article-title":"Diagnostic and therapeutic considerations in idiopathic systemic capillary leak syndrome: A case report","volume":"6","author":"Houterman","year":"2022","journal-title":"J. Emerg. Crit. Care Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1097\/CCM.0000000000002496","article-title":"The Clinical Picture of Severe Systemic Capillary-Leak Syndrome Episodes Requiring ICU Admission","volume":"45","author":"Luyt","year":"2017","journal-title":"Crit. 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