{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:09:19Z","timestamp":1763104159406,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Semmelweis University, Doctoral School, R\u00e1cz K\u00e1roly Conservative Medicine Division"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Hepatic fibrosis with various origins can be estimated non-invasively by using certain biomarkers and imaging-based measurements. The aim of our study was to examine redox homeostasis biomarkers and liver stiffness measurements for the assessment of significant liver fibrosis in different etiologies of chronic liver diseases. A cohort study consisting of 88 chronic liver disease patients of both sexes (age 49.1 \u00b1 14.7 years) was performed. Cytokine profiles as well as redox homeostasis characteristics were determined. Liver fibrosis stages were assessed with shear wave elastography. The plasma levels of four cytokines showed no significant alteration between the four fibrotic stages; however, higher values were measured in the F2\u20134 stages. Free sulfhydryl group concentration, the marker of redox homeostasis, was lower in significant fibrosis (F0\u2013F1: 0.36 \u00b1 0.06 vs. F2\u20134: 0.29 \u00b1 0.08 mmol\/L, p &lt; 0.05). Higher chemiluminescence values, as free radical\u2013antioxidant parameters, were detected in advanced fibrosis stages in erythrocytes (F0\u2013F1: 36.00 \u00b1 37.13 vs. F2\u20134: 51.47 \u00b1 44.34 RLU%). These data suggest that oxidative stress markers can predict significant fibrosis, with the aim of reducing the number of protocol liver biopsies in patients unlikely to have significant disease; however, their role in distinguishing between the certain fibrosis groups needs further studies.<\/jats:p>","DOI":"10.3390\/diagnostics14171945","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:06:41Z","timestamp":1725336401000},"page":"1945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Redox Homeostasis and Non-Invasive Assessment of Significant Liver Fibrosis by Shear Wave Elastography"],"prefix":"10.3390","volume":"14","author":[{"given":"Anna","family":"Egresi","sequence":"first","affiliation":[{"name":"Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1091 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bl\u00e1zovics","sequence":"additional","affiliation":[{"name":"Department of Surgical Research and Techniques, The Heart and Vascular Center, Semmelweis University, 1091 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Lengyel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 1091 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienn Gr\u00e9ta","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Centre for Bioinformatics, University of Veterinary Medicine, 1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Csongr\u00e1dy","sequence":"additional","affiliation":[{"name":"Department of Radiology, Semmelweis University, 1091 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Jakab","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, 1091 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-1320","authenticated-orcid":false,"given":"Krisztina","family":"Hagym\u00e1si","sequence":"additional","affiliation":[{"name":"Department of Radiology, Semmelweis University, 1091 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/MOG.0000000000000621","article-title":"The utility of liver biopsy in 2020","volume":"36","author":"Khalifa","year":"2020","journal-title":"Curr. 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