{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:35:00Z","timestamp":1787499300799,"version":"build-2736575974"},"reference-count":61,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Colon capsule endoscopy (CCE) has regained popularity for lower gastrointestinal investigations since the COVID-19 pandemic. While there have been systematic reviews and meta-analyses on colonic polyp detection using CCE, there is a lack of comprehensive evidence concerning colonic inflammation. Therefore, this systematic review and meta-analysis aimed to assess the diagnostic accuracy of CCE for colonic inflammation, predominantly ulcerative colitis (UC) and Crohn\u2019s disease (CD). Methods: We systematically searched electronic databases (EMBASE, MEDLINE, PubMed Central, and Cochrane Library) for studies comparing the diagnostic accuracy between CCE and optical endoscopy as the standard reference. A bivariate random effect model was used for the meta-analysis. Results: From 3797 publications, 23 studies involving 1353 patients were included. Nine studies focused on UC, and ten focused on CD. For UC, CCE showed a pooled sensitivity of 92% (95% CI, 88\u201395%), a specificity of 71% (95% CI, 35\u201392%), and an AUC of 0.93 (95% CI, 0.89\u20130.97). For CD, the pooled sensitivity was 92% (95% CI, 89\u201395%), and the specificity was 88% (95% CI, 84\u201392%), with an AUC of 0.87 (95% CI, 0.76\u20130.98). Overall, for inflammatory bowel disease, the pooled sensitivity, specificity, and AUC were 90% (95% CI, 85\u201393%), 76% (95% CI, 56\u201390%), and 0.92 (95% CI, 0.94\u20130.97), respectively. Conclusions: Despite the challenges around standardised disease scoring and the lack of histological confirmation, CCE performs well in diagnosing inflammatory bowel disease. It demonstrates high sensitivity in both UC and Crohn\u2019s terminal ileitis and colitis and high specificity in Crohn\u2019s disease. Further studies are needed to evaluate the diagnostic accuracy of other colonic inflammatory conditions.<\/jats:p>","DOI":"10.3390\/diagnostics14182056","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:36:00Z","timestamp":1726472160000},"page":"2056","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Diagnostic Accuracy of Colon Capsule Endoscopy in Inflammatory Bowel Disease\u2014A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6148-0963","authenticated-orcid":false,"given":"Ian Io","family":"Lei","sequence":"first","affiliation":[{"name":"Institute of Precision Diagnostics & Translational Medicine, University Hospital of Coventry and Warwickshire, Clifford Bridge Rd, Coventry CV2 2DX, UK"},{"name":"Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8980-8599","authenticated-orcid":false,"given":"Camilla","family":"Thorndal","sequence":"additional","affiliation":[{"name":"Surgical Research Unit, Odense University Hospital, 5700 Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shoaib","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sandwell and West Birmingham Hospitals NHS Trust, Hallam St., West Bromwich B71 4HJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9975-888X","authenticated-orcid":false,"given":"Nicholas","family":"Parsons","sequence":"additional","affiliation":[{"name":"Warwick Clinical Trials Unit, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Noble","sequence":"additional","affiliation":[{"name":"Noblesoft, Stamford, Lincs PE9 3DN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Huhulea","sequence":"additional","affiliation":[{"name":"Institute of Precision Diagnostics & Translational Medicine, University Hospital of Coventry and Warwickshire, Clifford Bridge Rd, Coventry CV2 2DX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-489X","authenticated-orcid":false,"given":"Anastasios","family":"Koulaouzidis","sequence":"additional","affiliation":[{"name":"Surgical Research Unit, Odense University Hospital, 5700 Svendborg, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark"},{"name":"Department of Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland"},{"name":"Department of Surgery, OUH Svendborg Sygehus, 5700 Svendborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2231-3062","authenticated-orcid":false,"given":"Ramesh P.","family":"Arasaradnam","sequence":"additional","affiliation":[{"name":"Institute of Precision Diagnostics & Translational Medicine, University Hospital of Coventry and Warwickshire, Clifford Bridge Rd, Coventry CV2 2DX, UK"},{"name":"Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK"},{"name":"Leicester Cancer Centre, University of Leicester, Leicester LE1 7RH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/codi.16029","article-title":"ScotCap\u2014A large observational cohort study","volume":"24","author":"MacLeod","year":"2022","journal-title":"Colorectal Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"E1712","DOI":"10.1055\/a-1546-8727","article-title":"Colon capsule endoscopy in colorectal cancer screening: Interim analyses of randomized controlled trial CareForColon2015","volume":"9","author":"Deding","year":"2021","journal-title":"Endosc. 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