{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:44:40Z","timestamp":1790725480942,"version":"4.1.0"},"reference-count":25,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Iuliu Hatieganu University\u2014School of Doctoral Studies","award":["PCD 2024-2026"],"award-info":[{"award-number":["PCD 2024-2026"]}]},{"name":"Iuliu Hatieganu University\u2014School of Doctoral Studies","award":["PN-IV-P8-8.3-ROMD-2023-0036"],"award-info":[{"award-number":["PN-IV-P8-8.3-ROMD-2023-0036"]}]},{"name":"Iuliu Hatieganu University\u2014School of Doctoral Studies","award":["PNRR\/2022\/C9\/MCID\/18"],"award-info":[{"award-number":["PNRR\/2022\/C9\/MCID\/18"]}]},{"name":"Iuliu Hatieganu University\u2014School of Doctoral Studies","award":["760278\/26.03.2024"],"award-info":[{"award-number":["760278\/26.03.2024"]}]},{"name":"European Hematology Association (EHA-SWG Immunotherapy Project 2024\u2014CAR NK cells for tumor associated macrophage immunomodulation\u2014a new era of immunotherapy)","award":["PCD 2024-2026"],"award-info":[{"award-number":["PCD 2024-2026"]}]},{"name":"European Hematology Association (EHA-SWG Immunotherapy Project 2024\u2014CAR NK cells for tumor associated macrophage immunomodulation\u2014a new era of immunotherapy)","award":["PN-IV-P8-8.3-ROMD-2023-0036"],"award-info":[{"award-number":["PN-IV-P8-8.3-ROMD-2023-0036"]}]},{"name":"European Hematology Association (EHA-SWG Immunotherapy Project 2024\u2014CAR NK cells for tumor associated macrophage immunomodulation\u2014a new era of immunotherapy)","award":["PNRR\/2022\/C9\/MCID\/18"],"award-info":[{"award-number":["PNRR\/2022\/C9\/MCID\/18"]}]},{"name":"European Hematology Association (EHA-SWG Immunotherapy Project 2024\u2014CAR NK cells for tumor associated macrophage immunomodulation\u2014a new era of immunotherapy)","award":["760278\/26.03.2024"],"award-info":[{"award-number":["760278\/26.03.2024"]}]},{"name":"bilateral collaboration","award":["PCD 2024-2026"],"award-info":[{"award-number":["PCD 2024-2026"]}]},{"name":"bilateral collaboration","award":["PN-IV-P8-8.3-ROMD-2023-0036"],"award-info":[{"award-number":["PN-IV-P8-8.3-ROMD-2023-0036"]}]},{"name":"bilateral collaboration","award":["PNRR\/2022\/C9\/MCID\/18"],"award-info":[{"award-number":["PNRR\/2022\/C9\/MCID\/18"]}]},{"name":"bilateral collaboration","award":["760278\/26.03.2024"],"award-info":[{"award-number":["760278\/26.03.2024"]}]},{"name":"Romanian Research Ministry\u2014PNRR 2024\u20132026","award":["PCD 2024-2026"],"award-info":[{"award-number":["PCD 2024-2026"]}]},{"name":"Romanian Research Ministry\u2014PNRR 2024\u20132026","award":["PN-IV-P8-8.3-ROMD-2023-0036"],"award-info":[{"award-number":["PN-IV-P8-8.3-ROMD-2023-0036"]}]},{"name":"Romanian Research Ministry\u2014PNRR 2024\u20132026","award":["PNRR\/2022\/C9\/MCID\/18"],"award-info":[{"award-number":["PNRR\/2022\/C9\/MCID\/18"]}]},{"name":"Romanian Research Ministry\u2014PNRR 2024\u20132026","award":["760278\/26.03.2024"],"award-info":[{"award-number":["760278\/26.03.2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Spontaneous remission of cancer is a rare and poorly understood phenomenon characterized by complete or partial remission of a malignancy in the absence of or with inadequate treatment. The underlying mechanism for such occurrences is poorly understood, however, immune mechanisms seem to play an important role in such cases. In recent years increasingly more data have become available in favor of the clinical benefit of low levels of chimerism in hematologic malignancies. One such instance of naturally occurring low-level chimerism is feto-maternal microchimerism which has been shown to influence cancer progression and, in some instances, to be a protective factor against malignancy. Case report: We report a case of a young female patient with aggressive primary mediastinal large B cell lymphoma refractory to two lines of chemo-immunotherapy achieving sustained complete metabolic remission of tumor while pregnant with twins. Results: A focus on feto-maternal microchimerism during and after pregnancy revealed transient levels of feto-maternal microchimerism in the peripheral blood of the patient as measured by quantifying the Y-chromosome-linked SRY gene. Conclusions: Microchimerism presents significant potential for enhancing our comprehension of disease mechanisms, uncovering novel therapeutic targets, and refining diagnostic and treatment approaches, especially concerning cancer.<\/jats:p>","DOI":"10.3390\/diagnostics14182084","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T07:38:57Z","timestamp":1726817937000},"page":"2084","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cLazarus Response\u201d When Feto-Maternal Microchimerism Kicks in: Spontaneous Remission in Refractory Primary Mediastinal B Cell Lymphoma Following Twin Pregnancy"],"prefix":"10.3390","volume":"14","author":[{"given":"Radu Andrei","family":"Tomai","sequence":"first","affiliation":[{"name":"Department of Haematology, Ion Chiricuta Institute of Oncology, 400015 Cluj-Napoca, Romania"},{"name":"Department of Translational Medicine, Institute of Medical Research and Life Sciences\u2014MEDFUTURE, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"},{"name":"Department of Hematology, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Iluta","sequence":"additional","affiliation":[{"name":"Department of Haematology, Ion Chiricuta Institute of Oncology, 400015 Cluj-Napoca, Romania"},{"name":"Department of Translational Medicine, Institute of Medical Research and Life Sciences\u2014MEDFUTURE, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"},{"name":"Department of Hematology, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-0791","authenticated-orcid":false,"given":"Adrian Bogdan","family":"Tigu","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Institute of Medical Research and Life Sciences\u2014MEDFUTURE, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5626-6911","authenticated-orcid":false,"given":"Madalina","family":"Nistor","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Institute of Medical Research and Life Sciences\u2014MEDFUTURE, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-9866","authenticated-orcid":false,"given":"Anamaria","family":"Bancos","sequence":"additional","affiliation":[{"name":"Department of Haematology, Ion Chiricuta Institute of Oncology, 400015 Cluj-Napoca, Romania"},{"name":"Department of Translational Medicine, Institute of Medical Research and Life Sciences\u2014MEDFUTURE, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"},{"name":"Department of Hematology, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Cenariu","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Institute of Medical Research and Life Sciences\u2014MEDFUTURE, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8807-4546","authenticated-orcid":false,"given":"Ciprian","family":"Jitaru","sequence":"additional","affiliation":[{"name":"Department of Haematology, Ion Chiricuta Institute of Oncology, 400015 Cluj-Napoca, Romania"},{"name":"Department of Translational Medicine, Institute of Medical Research and Life Sciences\u2014MEDFUTURE, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"},{"name":"Department of Hematology, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiu","family":"Patcas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-265X","authenticated-orcid":false,"given":"Delia","family":"Dima","sequence":"additional","affiliation":[{"name":"Department of Haematology, Ion Chiricuta Institute of Oncology, 400015 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6252-6281","authenticated-orcid":false,"given":"David","family":"Kegyes","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Institute of Medical Research and Life Sciences\u2014MEDFUTURE, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"},{"name":"Department of Hematology, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanda","family":"Buruiana","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nicolae Testemitanu University of Medicine and Pharmacy, MD-2004 Chisinau, Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-987X","authenticated-orcid":false,"given":"Mihnea","family":"Zdrenghea","sequence":"additional","affiliation":[{"name":"Department of Haematology, Ion Chiricuta Institute of Oncology, 400015 Cluj-Napoca, Romania"},{"name":"Department of Hematology, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-499X","authenticated-orcid":false,"given":"Alina Daniela","family":"Tanase","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation, Fundeni Clinical Institute, 022338 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-1519","authenticated-orcid":false,"given":"Ciprian","family":"Tomuleasa","sequence":"additional","affiliation":[{"name":"Department of 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