{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:30:10Z","timestamp":1760146210990,"version":"build-2065373602"},"reference-count":8,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A 65-year-old woman was admitted to the neurology department with a suspected demyelinating disease due to complaints of progressive pain and weakness in both upper and lower limbs, as well as urinary incontinence. MRI of the spine revealed complex disc osteophyte with compression of the spinal cord in the cervical and lumbar spine at several vertebral levels, and localized enhancement in the cervical spine at the site of maximal spinal canal stenosis. During her hospitalization, the patient underwent extensive evaluation to rule out any systematic inflammatory diseases, infections, and malignancy. Chest CT revealed bilateral mediastinal lymphadenopathy. Transbronchial mediastinal lymph node biopsy showed numerous non-necrotizing granulomas without evidence of malignancy. After a thorough and careful exclusion of a demyelinating, infectious, and paraneoplastic myelopathies, and based on clinical, radiographic, and pathological findings, the patient was diagnosed with both neurosarcoidosis and spondylotic myelopathy. She was then treated for neurosarcoidosis, including glucocorticosteroids, azathioprine, and a biosimilar of the anti-TNF alpha agent infliximab, resulting in both clinical and radiographic improvement. Intramedullary spinal neurosarcoidosis is very rare and may present with clinical features of spondylotic myelopathy, with typical imaging findings occurring only in areas of spinal canal stenosis.<\/jats:p>","DOI":"10.3390\/diagnostics14202296","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T07:58:32Z","timestamp":1729065512000},"page":"2296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurosarcoidosis Masquerading as Spinal Stenosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Ameen","family":"Batheesh","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Carmel Medical Center, Haifa 3436212, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Borissovsky","sequence":"additional","affiliation":[{"name":"Department of Radiology, Carmel Medical Center, Haifa 3436212, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devy","family":"Zisman","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-2698","authenticated-orcid":false,"given":"Tal","family":"Gazitt","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1212\/NXI.0000000000000722","article-title":"Clinical and MRI phenotypes of sarcoidosis-associated myelopathy","volume":"7","author":"Murphy","year":"2020","journal-title":"Neurol. Neuroimmunol. NeuroInfl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1055\/a-2114-1350","article-title":"Cervical myelitis: A practical approach to its differential diagnosis on MR imaging","volume":"Volume 195","author":"Weidauer","year":"2023","journal-title":"R\u00f6Fo-Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der Bildgebenden Verfahren"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"577871","DOI":"10.1016\/j.jneuroim.2022.577871","article-title":"Clinical features and diagnosis of neurosarcoidosis\u2014Review article","volume":"368","author":"Barreras","year":"2022","journal-title":"J. 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Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1001\/jamaneurol.2018.2295","article-title":"Definition and Consensus Diagnostic Criteria for Neurosarcoidosis: From the Neurosarcoidosis Consortium Consensus Group","volume":"75","author":"Stern","year":"2018","journal-title":"JAMA Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11926-022-01089-z","article-title":"Neurosarcoidosis: Phenotypes, Approach to Diagnosis and Treatment","volume":"24","author":"Gosselin","year":"2022","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3174\/ajnr.A7724","article-title":"Spinal cord sarcoidosis occurring at sites of spondylotic stenosis, mimicking spondylotic myelopathy: A case series and review of the literature","volume":"44","author":"Kurtz","year":"2024","journal-title":"AJNR Am. J. Neuroradiol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/20\/2296\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:14:21Z","timestamp":1760112861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/20\/2296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":8,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["diagnostics14202296"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14202296","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2024,10,16]]}}}