{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:55:37Z","timestamp":1785200137733,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objective: Invasive candidiasis is defined as an important infection that increases the duration of patients\u2019 hospital stay, costs, mortality and morbidity. In this study, we aimed to investigate the frequency of candidiasis in blood cultures of pediatric hematology patients, Candida species, antifungal susceptibilities, and their effects on mortality. Materials and Methods: Patients with Candida growth in their blood cultures at follow-up in the pediatric hematology clinic of our hospital between 2020 and 2024 were included in the study. Age, gender, primary diseases and risk levels, subtypes and antifungal susceptibilities of Candida grown in blood cultures, the presence of neutropenia in patients, the antifungals used for prophylaxis and treatment, the duration of infection, other bacteria grown additionally during the fungal infection period, the local infection source and the patients\u2019 discharge status were obtained from medical records. These constituted the study data. Results: Blood cultures were requested for 594 patients from the Pediatric hematology Clinic, and Candida was grown in only 37 (6.7%) of them. A total of 43.2% of them were the Candida parapsilosis complex, 29.7% were Candida albicans and 8.1% were the Candida haemulonii complex. Antifungal susceptibilities were over 90% for anidulafungin, micafungin, caspofungin, posaconazole, itraconazole and amphotericin B, followed by 86.7% for fluconazole and 84.4% for voriconazole. The mean age of the patient group was 6.8 years, 50.5% of whom were female and 40.5% of whom were male. The Candida infections developed on the 12.1th day of the neutropenia process on average. The mean invasive Candida infection period was 7 days. A total of 18.9% had a second bacterial infection and 13.5% had a local infection. A total of 51.4% had a single antifungal, 18.9% had two antifungals and 2.1% had more than two antifungals. A total of 35.1% of the patients with invasive candidiasis died. The primary diagnosis of the disease, Patient risk level, and the female gender were important factors affetting mortality. Conclusions: In a pediatric hematology clinic, the non-albicans group in invasive candidiasis infections was notable, with the C. parapsilosis complex occurring most frequently. There was still a high sensitivity to echinocandin antifungals and a decreased sensitivity to triazoles. It was found that the factor of the clinical diagnosis, being in the high-risk group and being female had significant effects on the survival rate of patients with candidiasis infections.<\/jats:p>","DOI":"10.3390\/diagnostics14202343","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T12:40:32Z","timestamp":1729514432000},"page":"2343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Candidemia in Pediatric-Clinic: Frequency of Occurrence, Candida Species, Antifungal Susceptibilities, and Effects on Mortality (2020\u20132024)"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-5637","authenticated-orcid":false,"given":"Kamuran","family":"\u015eanl\u0131","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, University of Health Science, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-5039","authenticated-orcid":false,"given":"Esra","family":"Arslanta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, University of Health Science, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-6873","authenticated-orcid":false,"given":"Ay\u015fe Nur","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, University of Health Science, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-8635","authenticated-orcid":false,"given":"Beyza","family":"\u00d6ncel","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, University of Health Science, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"\u00d6zkorucu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, University of Health Science, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4758-3808","authenticated-orcid":false,"given":"Ay\u015fe","family":"\u00d6zkan Karagen\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, University of Health Science, Istanbul 34480, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bongomin, F., Gago, S., Oladele, R.O., and Denning, D.W. (2017). Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision. J. Fungi, 3.","DOI":"10.3390\/jof3040057"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/INF.0b013e3181a0d78d","article-title":"Epidemiology of candidemia at a Children\u2019s Hospital, 2002 to 2006","volume":"28","author":"Neu","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1469-0691.2011.03720.x","article-title":"Candidaemia in a European Paediatric University Hospital: A 10-year observational study","volume":"18","author":"Tragiannidis","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_4","first-page":"B4698","article-title":"Candida and candidaemia. Susceptibility and epidemiology","volume":"60","author":"Arendrup","year":"2013","journal-title":"Dan. Med. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/08880010801938231","article-title":"Assessment of febrile neutropenia episodes in children with acute leukemia treated with BFM protocols","volume":"25","author":"Oren","year":"2008","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_6","first-page":"94","article-title":"Invasive Fungal Infections in Children with Leukemia: Clinical Features and Prognosis","volume":"39","author":"Baytan","year":"2022","journal-title":"Turk. J. Haematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.5578\/mb.20219709","article-title":"Mortality Risk Factors for Invasive Candidiasis in Pediatric Intensive Care Unit","volume":"55","author":"Korulmaz","year":"2021","journal-title":"Mikrobiyol. Bul."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5152\/kd.2015.24","article-title":"Evaluation of Candida Species and Risk Factors in Haematologic Cancer Patients with Candidemia","volume":"28","author":"Akan","year":"2015","journal-title":"Klimik Derg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1200\/JCO.2015.62.3488","article-title":"Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update","volume":"33","author":"Smith","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and Update of the Consensus Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium","volume":"71","author":"Donnelly","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/01.inf.0000078159.53132.40","article-title":"Nosocomial bloodstream infections in pediatric patients in United States hospitals: Epidemiology, clinical features and susceptibilities","volume":"22","author":"Wisplinghoff","year":"2003","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/cid\/cit679","article-title":"Decreasing rates of invasive candidiasis in pediatric hospitals across the United States","volume":"58","author":"Fisher","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0891-5520(05)70156-2","article-title":"Infectious complications of febrile leukopenia","volume":"15","author":"Giamarellou","year":"2001","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_14","first-page":"35","article-title":"\u00c7ocuklarda Febril N\u00f6tropeni","volume":"29","year":"2003","journal-title":"Uluda\u011f \u00dcniversitesi T\u0131p Fak\u00fcltesi Derg."},{"key":"ref_15","first-page":"37","article-title":"Invasive fungal infections in a pediatric hematology-oncology department: A 16-year retrospective study","volume":"6","author":"Kazakou","year":"2020","journal-title":"Curr. Med. Mycol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1016\/S1470-2045(20)30723-3","article-title":"8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation","volume":"22","author":"Groll","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.diagmicrobio.2009.03.010","article-title":"Epidemiology and outcome of multiple-species candidemia at a tertiary care center between 2004 and 2007","volume":"64","author":"Nace","year":"2009","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/bjh.16452","article-title":"Fungal infections in children with haematologic malignancies and stem cell transplant recipients","volume":"189","author":"Otto","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"ofac088","DOI":"10.1093\/ofid\/ofac088","article-title":"Hepatosplenic Candidiasis in Patients With Hematological Malignancies: A 13-Year Retrospective Cohort Study","volume":"9","author":"Boussen","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/MPH.0000000000001468","article-title":"Frequency and determinants of invasive fungal infections in children with solid and hematologic malignancies in a nonallogeneic stem cell transplantation setting: A narrative review","volume":"41","author":"Ruijters","year":"2019","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_22","first-page":"93","article-title":"Evaluation of Febrile Neutropenia in Children with Acute Leukemia","volume":"6","author":"Bay","year":"2012","journal-title":"Turkish J. Pediatr. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.36472\/msd.v10i2.868","article-title":"Investigation of Candidemia Diagnosis by PCR Method in Febrile Neutropenic Patients with Hematological Malignancies: Hematological Malignancies and Candidemia","volume":"10","author":"Yaman","year":"2023","journal-title":"Med. Sci. Discov."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5152\/ced.2012.39","article-title":"Nosocomial Infections in Pediatric Cancer Patients","volume":"6","author":"Kavurt","year":"2012","journal-title":"J. Pediatr. Infect."},{"key":"ref_25","first-page":"147","article-title":"Evaluation of Risk Factors in Invasive Candida Infections in Children","volume":"17","author":"Yasa","year":"2023","journal-title":"J. Pediatr. Infect."},{"key":"ref_26","first-page":"245","article-title":"Childhood Candida Infections: Single Center Experience","volume":"40","author":"Soysal","year":"2015","journal-title":"Cukurova Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4103\/0019-509X.175311","article-title":"Epidemiology of blood stream infections in pediatric patients at a Tertiary Care Cancer Centre","volume":"51","author":"Thacker","year":"2014","journal-title":"Indian J. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00520-003-0453-9","article-title":"Non-albicans Candida is the most common cause of candidemia in pediatric cancer patients","volume":"11","author":"Mullen","year":"2003","journal-title":"Support. Care Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1007\/s42770-023-01163-3","article-title":"The impact of increasing non-albicans Candida trends on diagnostics in immunocompromised patients","volume":"54","author":"Abdelfattah","year":"2023","journal-title":"Braz. J. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Vasileiou, E., Paisiou, A., Tsipou, C., Pourtsidis, A., Galani, V., Katzilakis, N., Antoniadi, K., Papakonstantinou, E., Ioannidou, E., and Stiakaki, E. (2020). Candidemia in Children with Malignancies: Report from the Infection Working Group of the Hellenic Society of Pediatric Hematology-Oncology. J. Fungi., 6.","DOI":"10.3390\/jof6040276"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1185\/03007995.2010.487796","article-title":"Candidemi in children","volume":"26","author":"Zaotis","year":"2010","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Arastehfar, A., Hilmio\u011flu-Polat, S., Daneshnia, F., Pan, W., Hafez, A., Fang, W., Liao, W., \u015eahbudak-Bal, Z., Metin, D.Y., and J\u00fanior, J.N.A. (2021). Clonal Candidemia Outbreak by Candida parapsilosis Carrying Y132F in Turkey: Evolution of a Persisting Challenge. Front. Cell Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.676177"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/2047-783X-16-4-187","article-title":"Epidemiology and antifungal resistance in invasive candidiasis","volume":"16","author":"Rodloff","year":"2011","journal-title":"Eur. J. Med. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"105799","DOI":"10.1016\/j.ijantimicag.2019.09.003","article-title":"Analysis of global antifungal surveillance results reveals predominance of Erg11 Y132F alteration among azole-resistant Candida parapsilosis and Candida tropicalis and country-specific isolate dissemination","volume":"55","author":"Castanheira","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jgar.2019.04.003","article-title":"First multicentre report of in vitro resistance rates in candidaemia isolates in Turkey","volume":"18","author":"Birinci","year":"2019","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5152\/TurkPediatriArs.2017.5291","article-title":"Evaluation of Candida species and antifungal susceptibilities among children with invasive candidiasis","volume":"52","author":"Acar","year":"2017","journal-title":"Turk. Pediatri Ars."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/20\/2343\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:17:45Z","timestamp":1760113065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/20\/2343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":36,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["diagnostics14202343"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14202343","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,21]]}}}