{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:30:30Z","timestamp":1760146230447,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Evidence from randomized controlled trials has shown a benefit for endovascular treatment in basilar artery occlusion. We aimed to show the effect of the recanalization result on outcome and determine the role of underlying basilar stenosis in a real-world setting. Methods: A retrospective, single-center study of patients who received endovascular treatment for basilar artery occlusion from March 2008 to June 2022 was conducted. Clinical and outcome characteristics were gathered. Multivariate logistic regression analysis was performed to predict poor outcomes (post-treatment mRS 5 or 6). MRS shift analysis was performed. Results: This study includes 210 patients (mean age, 71.4 years +\/\u2212 13.3 [standard deviation]; 124 men). The variables age (OR, 1.04; 95% CI: 1.01\u20131.08; p = 0.014), underlying basilar stenosis (OR: 4.86; 95% CI: 2.15\u201310.98; p &lt; 0.001), admission NHISS (OR: 1.09; 95% CI: 1.04\u20131.13; p &lt; 0.001), and TICI (OR: 1.89; 95% CI: 1.09\u20133.25; p = 0.022) independently predicted a poor outcome. Patients with occlusions due to underlying stenosis had significantly worse recanalization rates. Median post-treatment mRS in all patients with embolic occlusion was 4; IQR, 2\u20135 (only patients with embolic occlusion: mTICI 0-2a, median: 5 [IQR, 4\u20135.5]; mTICI 2b, median: 4 [IQR, 2.5\u20136]; mTICI 3, median: 3 [IQR, 1\u20135]; p = 0.037). Median post-treatment mRS in all patients with occlusions due to underlying stenosis was 5; IQR, 4\u20136 (only patients with embolic occlusions: mTICI 0-2a, median: 6 [IQR, 4.5\u20136]; mTICI 2b, median: 6 [IQR, 4.25\u20136]; mTICI 3, median: 5 [IQR, 3.5\u20135.25]; p = 0.059). Conclusions: Successful recanalization is essential for preventing poor outcomes in basilar artery occlusion. Underlying basilar stenosis diminishes the effect of successful recanalization on the overall outcome.<\/jats:p>","DOI":"10.3390\/diagnostics14212348","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T06:11:25Z","timestamp":1729577485000},"page":"2348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Basilar Stenosis Reduces the Impact of Successful Recanalization on Outcome in Basilar Artery Occlusion"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-3863","authenticated-orcid":false,"given":"Moritz R.","family":"Hernandez Petzsche","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9768-9630","authenticated-orcid":false,"given":"Philip","family":"Hoelter","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Universit\u00e4tsklinikum Erlangen, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"R\u00fchling","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Schwarting","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benno","family":"Ikenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Wunderlich","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Maegerlein","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9124-231X","authenticated-orcid":false,"given":"Maria","family":"Berndt-M\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Boeckh-Behrens","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S1474-4422(11)70229-0","article-title":"Basilar artery occlusion","volume":"10","author":"Mattle","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s00115-021-01123-y","article-title":"Endovascular treatment of acute basilar artery occlusions","volume":"92","author":"Maegerlein","year":"2021","journal-title":"Nervenarzt"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S1474-4422(09)70173-5","article-title":"Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): A prospective registry study","volume":"8","author":"Schonewille","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1056\/NEJMoa2206317","article-title":"Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion","volume":"387","author":"Tao","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/jamaneurol.2020.0156","article-title":"Assessment of Endovascular Treatment for Acute Basilar Artery Occlusion via a Nationwide Prospective Registry","volume":"77","author":"Zi","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1056\/NEJMoa2207576","article-title":"Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion","volume":"387","author":"Jovin","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1148\/radiol.2019181924","article-title":"Mechanical Thrombectomy in Subtypes of Basilar Artery Occlusion: Relationship to Recanalization Rate and Clinical Outcome","volume":"291","author":"Baik","year":"2019","journal-title":"Radiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/STROKEAHA.119.027472","article-title":"From Perviousness to Plaque Imaging in Acute Basilar Occlusions: The Impact of Underlying Stenosis and How to Detect It","volume":"51","author":"Berndt","year":"2020","journal-title":"Stroke"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1007\/s00330-024-10755-y","article-title":"Impact of ischemic stroke topography on early clinical outcome of basilar artery occlusion: A retrospective study","volume":"34","author":"Maegerlein","year":"2024","journal-title":"Eur. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.3174\/ajnr.A4844","article-title":"Effect of Intracranial Atherosclerotic Disease on Endovascular Treatment for Patients with Acute Vertebrobasilar Occlusion","volume":"37","author":"Kim","year":"2016","journal-title":"Am. J. Neuroradiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1161\/STROKEAHA.118.022466","article-title":"Vertebral Artery Patency and Thrombectomy in Basilar Artery Occlusions","volume":"50","author":"Pree","year":"2019","journal-title":"Stroke"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mueck, F., Hernandez Petzsche, M., Boeckh-Behrens, T., Maegerlein, C., Linsenmaier, U., Scaglione, M., Zimmer, C., Ikenberg, B., and Berndt, M. (2022). CT Marker in Emergency Imaging of Acute Basilar Artery Occlusion: Thrombosis vs. Embolism. Diagnostics, 12.","DOI":"10.3390\/diagnostics12081817"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1161\/STROKEAHA.111.644484","article-title":"Seven-day NIHSS is a sensitive outcome measure for exploratory clinical trials in acute stroke: Evidence from the Virtual International Stroke Trials Archive","volume":"43","author":"Kerr","year":"2012","journal-title":"Stroke"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1161\/01.STR.0000181089.41324.70","article-title":"Investigators. Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials","volume":"36","author":"Young","year":"2005","journal-title":"Stroke"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jamaneurol.2021.4346","article-title":"Twenty-Year Change in Severity and Outcome of Ischemic and Hemorrhagic Strokes","volume":"79","author":"Toyoda","year":"2022","journal-title":"JAMA Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1161\/STROKEAHA.113.001972","article-title":"Recommendations on angiographic revascularization grading standards for acute ischemic stroke: A consensus statement","volume":"44","author":"Zaidat","year":"2013","journal-title":"Stroke"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1136\/jnnp-2014-310250","article-title":"Outcomes of stent retriever thrombectomy in basilar artery occlusion: An observational study and systematic review","volume":"87","author":"Gory","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00062-019-00850-9","article-title":"Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion","volume":"30","author":"Flottmann","year":"2020","journal-title":"Clin. Neuroradiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105080","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105080","article-title":"Anterior circulation large vessel occlusion stroke in Saudi Arabia: Prevalence, predictors, and outcome","volume":"29","author":"Aldriweesh","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1212\/WNL.0b013e31824e8f40","article-title":"Predicting outcome after acute basilar artery occlusion based on admission characteristics","volume":"78","author":"Greving","year":"2012","journal-title":"Neurology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.pmr.2015.07.002","article-title":"Predictors of Functional Outcome Following Stroke","volume":"26","author":"Harvey","year":"2015","journal-title":"Phys. Med. Rehabil. Clin."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e1021","DOI":"10.4244\/EIJ-D-19-00519","article-title":"Coronary stent implantation for acute basilar artery occlusion with underlying stenosis","volume":"16","author":"Nardai","year":"2020","journal-title":"EuroIntervention"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1055\/s-2008-1070010","article-title":"Local fibrinolysis in basilar artery thrombosis (author\u2019s transl)","volume":"107","author":"Zeumer","year":"1982","journal-title":"Dtsch. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/STROKEAHA.116.015492","article-title":"The Basilar Artery on Computed Tomography Angiography Prognostic Score for Basilar Artery Occlusion","volume":"48","author":"Alemseged","year":"2017","journal-title":"Stroke"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/STROKEAHA.116.015492","article-title":"Response to Late-Window Endovascular Revascularization Is Associated With Collateral Status in Basilar Artery Occlusion","volume":"48","author":"Alemseged","year":"2019","journal-title":"Stroke"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/jnnp.2003.020479","article-title":"Clinical and radiological predictors of recanalisation and outcome of 40 patients with acute basilar artery occlusion treated with intra-arterial thrombolysis","volume":"75","author":"Arnold","year":"2004","journal-title":"J. Neurol Neurosurg Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e010962","DOI":"10.1161\/JAHA.118.010962","article-title":"Rapid Successful Reperfusion of Basilar Artery Occlusion Strokes With Pretreatment Diffusion-Weighted Imaging Posterior-Circulation ASPECTS<8 Is Associated With Good Outcome","volume":"8","author":"Guillaume","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2019.04.010","article-title":"Endovascular treatment of acute basilar artery occlusion: Tama-REgistry of Acute Thrombectomy (TREAT) study","volume":"401","author":"Kaneko","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"ref_30","first-page":"e9","article-title":"One-Year Outcome After Endovascular Treatment for Acute Basilar Artery Occlusion","volume":"53","author":"Li","year":"2021","journal-title":"Stroke"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/2396987316629889","article-title":"Recanalization treatments in basilar artery occlusion-Systematic analysis","volume":"1","author":"Lindsberg","year":"2016","journal-title":"Eur. Stroke J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1136\/neurintsurg-2015-012089","article-title":"Outcomes of endovascular treatment of basilar artery occlusion in the stent retriever era: A systematic review and meta-analysis","volume":"8","author":"Phan","year":"2016","journal-title":"J. Neurointerv. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.12688\/f1000research.18042.1","article-title":"Therapy for acute basilar artery occlusion: A systematic review and meta-analysis","volume":"8","author":"Sheng","year":"2019","journal-title":"F1000Research"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00062-018-0683-3","article-title":"Revascularization Techniques for Acute Basilar Artery Occlusion: Technical Considerations and Outcome in the Setting of Severe Posterior Circulation Steno-Occlusive Disease","volume":"29","author":"Siebert","year":"2019","journal-title":"Clin. Neuroradiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1007\/s10072-021-05072-x","article-title":"Multimodal CT pc-ASPECTS in infratentorial stroke: Diagnostic and prognostic value","volume":"42","author":"Caruso","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.03.033","article-title":"Etiology and Risk Factors of Posterior Circulation Infarction Compared with Anterior Circulation Infarction","volume":"24","author":"Zeng","year":"2015","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1474-4422(19)30395-3","article-title":"Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): An open-label, randomised controlled trial","volume":"19","author":"Liu","year":"2020","journal-title":"Lancet Neurol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/21\/2348\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:17:36Z","timestamp":1760113056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/21\/2348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":37,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["diagnostics14212348"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14212348","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2024,10,22]]}}}