{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:30:15Z","timestamp":1789072215412,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Appendiceal mucocele is a rare entity first described by Carl von Rokitansky, characterized by cystic dilatation of the appendiceal lumen due to obstruction, epithelial proliferation or inflammation and accumulation of mucoid material. The cause can be either neoplastic or non-neoplastic. Patients with appendiceal mucocele can be asymptomatic or present with right lower quadrant pain which may mimic acute appendicitis. We present the case of a 68-year-old male, who presented to the Emergency Room with a two-day history of right lower quadrant pain, nausea, vomiting and loss of appetite. Abdominal examination revealed tenderness over the Mc Burney point with localized guarding and laboratory results showed leukocytosis with neutrophilia. The abdominal computed tomography revealed a cystic dilated appendix, with a length of 130 mm and a diameter of 75 mm, situated ascending retrocecal and associating peri-appendicular inflammatory changes. The patient underwent right hemicolectomy with side-to-side ileo-colonic anastomosis, due to a wide intraluminal communication between the appendix and the cecum and the inflammation of both structures. Histopathological examination showed both high-grade and low-grade appendiceal mucinous neoplasm.<\/jats:p>","DOI":"10.3390\/diagnostics14212429","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T08:44:04Z","timestamp":1730364244000},"page":"2429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Giant Appendiceal Mucocele with High Grade Mucinous Neoplasm\u2014Case Report and Review of the Literature"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2854-7449","authenticated-orcid":false,"given":"Laurentiu Vasile","family":"Sima","sequence":"first","affiliation":[{"name":"Department of Surgery I, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Ana-Maria","family":"Dan","sequence":"additional","affiliation":[{"name":"Department of Surgery I, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Zara","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"},{"name":"Department of Pathology, Emergency City Hospital, 300254 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1397-1864","authenticated-orcid":false,"given":"Raluca Maria","family":"Closca","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"},{"name":"Department of Pathology, Emergency City Hospital, 300254 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-9924","authenticated-orcid":false,"given":"Alexandra Christa","family":"Sima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Oana","family":"Saracin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Emergency City Hospital, 300254 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Gheorghe","family":"Dan","sequence":"additional","affiliation":[{"name":"Department of Surgery I, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Maria","family":"Orzata","sequence":"additional","affiliation":[{"name":"Department of Emergency General Surgery, Emergency City Hospital, 300254 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"ref_1","first-page":"33","article-title":"Mucocele of the Appendix","volume":"27","author":"Louis","year":"2014","journal-title":"Proc. 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