{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:34:10Z","timestamp":1790015650851,"version":"4.0.1"},"reference-count":55,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: This study aimed to explore a relationship between the fetal subarachnoid space (SAS) width and various fetal pathologies, employing fetal brain MRI scans. Methods: A retrospective collection of fetal brain MRI scans of 78 fetuses was performed with sonographic indications of microcephaly, macrocephaly, or fetal growth restriction (FGR), during a 7-year period at a single tertiary center. The SAS width (named the SAS index) was manually measured in millimeters in ten specific anatomical locations (four in the axial plane and six in the coronal plane), and then converted to centiles by comparing it to (previously collected) data of apparently healthy fetuses. We evaluated the median SAS centiles using the Kruskal\u2013Wallis and Mann\u2013Whitney U tests for statistical comparison. Results: Seventy-eight subjects (mean gestational age of MRI scan 34.2 \u00b1 2.2 weeks) were evaluated. The median SAS centiles were consistently higher in the macrocephaly group compared to the microcephaly group in all ten anatomical locations (statistically significant except coronal left inferior temporal gyri). Most pronounced difference was displayed in the insula gyri (axial and coronal). The median SAS centiles were higher in the microcephaly group when compared with FGR across all ten anatomical locations (all were statistically significant except for coronal frontal and insula gyri), and the maximal difference was found in the frontal gyri of both planes. The median SAS indexes (IQR) of the three groups in millimeters: macrocephaly 91.55 (86.35\u2013101.05), microcephaly 59.46 (50.00\u201366.91), and FGR 53.21 (49.71\u201359.10), p &lt; 0.001. Conclusions: We found a statistically significant association between the fetal subarachnoid space and various fetal pathologies: macrocephaly, microcephaly, and FGR.<\/jats:p>","DOI":"10.3390\/diagnostics14222535","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T06:10:48Z","timestamp":1731478248000},"page":"2535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An Association Between Fetal Subarachnoid Space and Various Pathologies Using MR Imaging"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7557-889X","authenticated-orcid":false,"given":"Lior","family":"Onn-Margalit","sequence":"first","affiliation":[{"name":"Arrow Program for Medical Research Education, Sheba Medical Center, Ramat-Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-7871","authenticated-orcid":false,"given":"Tal","family":"Weissbach","sequence":"additional","affiliation":[{"name":"Arrow Program for Medical Research Education, Sheba Medical Center, Ramat-Gan 5262000, Israel"},{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan 5262000, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-7334","authenticated-orcid":false,"given":"Michal","family":"Gafner","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Pediatrics B, Schneider Children\u2019s Medical Center of Israel, Petach Tikva 4917002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1306-222X","authenticated-orcid":false,"given":"Shalev","family":"Fried","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Goldschleger Eye Institute, Sheba Medical Center, Ramat-Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Wandel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Diagnostic Radiology, Shamir Medical Center, Be\u2019er Yaakov 7033001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2589-8473","authenticated-orcid":false,"given":"Tomer","family":"Ziv-Baran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldad","family":"Katorza","sequence":"additional","affiliation":[{"name":"Arrow Program for Medical Research Education, Sheba Medical Center, Ramat-Gan 5262000, Israel"},{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan 5262000, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat-Gan 5262000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.wneu.2017.12.041","article-title":"Subarachnoid trabeculae: A comprehensive review of their embryology, histology, morphology, and surgical significance","volume":"111","author":"Mortazavi","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.2463\/mrms.rev.2020-0122","article-title":"The glymphatic system: A review of the challenges in visualizing its structure and function with MR imaging","volume":"21","author":"Naganawa","year":"2022","journal-title":"Magn. 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