{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:49:11Z","timestamp":1786416551778,"version":"build-2736575974"},"reference-count":37,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objective: Patients with chronic idiopathic intracranial hypertension (IIH) commonly experience a high level of disability and low satisfaction with medical treatment. We aim to evaluate long-term functional improvement and patient satisfaction in IIH patients with similar symptoms by comparing venous sinus stenting (VSS) to standard medical therapy. Methods: We conducted a cross-sectional questionnaire study of 111 IIH patients, comparing 37 adult female patients who underwent venous sinus stenting with 74 patients treated medically. Propensity score matching was used to balance age and presence of papilledema at presentation between groups. Headache-related disability was evaluated using the Migraine Disability Assessment Scale (MIDAS), while general function and treatment satisfaction were assessed using custom questionnaires. Electronic medical records and the results of imaging upon diagnosis were reviewed retrospectively. Results: The stented group reported significantly better outcomes in physical well-being (median 4.0 vs. 1.0, p &lt; 0.001), task completion (4.0 vs. 1.0, p &lt; 0.001), work\/school persistence (5.0 vs. 1.0, p &lt; 0.001), and mental well-being (4.0 vs. 1.0, p &lt; 0.001). Additionally, the stented group had a lower proportion of patients with severe MIDAS (MIDAS &gt; 4, 24.3% vs. 47.9%, p = 0.017). Logistic regression suggested venous stenting as a protective factor against severe MIDAS scores (OR = 0.174, p = 0.004). Conclusion: Cerebral venous stenting in patients with IIH is associated with lower disability and higher patient satisfaction from medical treatment compared to those treated with medications only. These findings suggest that venous sinus stenting may be a valuable treatment option for selected IIH patients. However, larger prospective studies are needed to further validate our results.<\/jats:p>","DOI":"10.3390\/diagnostics14222572","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T07:45:27Z","timestamp":1731915927000},"page":"2572","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Disability and Patient-Reported Satisfaction in Women with Idiopathic Intracranial Hypertension: A Comparative Study of Venous Sinus Stenting and Medical Management"],"prefix":"10.3390","volume":"14","author":[{"given":"Ortal","family":"Buhbut","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8453227, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas","family":"Ben Assayag","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapir","family":"Aharoni-Bar","sequence":"additional","affiliation":[{"name":"Ben-Gurion Medical School, Soroka University Medical Center, Beer Sheva 8453227, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-7664","authenticated-orcid":false,"given":"Maor","family":"Epstein","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8148-6561","authenticated-orcid":false,"given":"Erez","family":"Tsumi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8453227, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamir","family":"Regev","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8453227, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bunin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8453227, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9489-0133","authenticated-orcid":false,"given":"Asaf","family":"Honig","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8453227, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar O.","family":"Kotaro","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health, Palacky University, 77900 Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gal","family":"Ben Arie","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Horev","sequence":"additional","affiliation":[{"name":"Department of Neurology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva 8453227, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/jnnp-2017-317440","article-title":"Idiopathic intracranial hypertension: Consensus guidelines on management","volume":"89","author":"Mollan","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1186\/s10194-015-0521-9","article-title":"Headache determines quality of life in idiopathic intracranial hypertension","volume":"16","author":"Mulla","year":"2015","journal-title":"J. Headache Pain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1212\/WNL.54.2.319","article-title":"Idiopathic intracranial hypertension: Relationship to depression, anxiety, and quality of life","volume":"54","author":"Kleinschmidt","year":"2000","journal-title":"Neurology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e004376","DOI":"10.1136\/bmjopen-2013-004376","article-title":"Cognitive function in idiopathic intracranial hypertension: A prospective case-control study","volume":"4","author":"Yri","year":"2014","journal-title":"BMJ Open"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1212\/WNL.0000000000001687","article-title":"Quality of life in idiopathic intracranial hypertension at diagnosis: IIH Treatment Trial results","volume":"84","author":"Digre","year":"2015","journal-title":"Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Stetter, C., Weidner, F., Lilla, N., Weiland, J., Kunze, E., Ernestus, R.I., Muellenbach, R.M., and Westermaier, T. (2021). Therapeutic hypercapnia for prevention of secondary ischemia after severe subarachnoid hemorrhage: Physiological responses to continuous hypercapnia. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-91007-7"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bulli, I., Dettori, I., Coppi, E., Cherchi, F., Venturini, M., Di Cesare Mannelli, L., Ghelardini, C., Nocentini, A., Supuran, C.T., and Pugliese, A.M. (2021). Role of Carbonic Anhydrase in Cerebral Ischemia and Carbonic Anhydrase Inhibitors as Putative Protective Agents. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22095029"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"122948","DOI":"10.1016\/j.jns.2024.122948","article-title":"Venous sinus stenting for idiopathic intracranial hypertension: An updated Meta-analysis","volume":"459","author":"Azzam","year":"2024","journal-title":"J. Neurol. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"NORDIC Idiopathic Intracranial Hypertension Study Group Writing Committee, Wall, M., McDermott, M.P., Kieburtz, K.D., Corbett, J.J., Feldon, S.E., Friedman, D.I., Katz, D.M., Keltner, J.L., and Schron, E.B. (2014). Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: The idiopathic intracranial hypertension treatment trial. JAMA, 311, 1641\u20131651.","DOI":"10.1001\/jama.2014.3312"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/head.13153","article-title":"Headache in Idiopathic Intracranial Hypertension: Findings From the Idiopathic Intracranial Hypertension Treatment Trial","volume":"57","author":"Friedman","year":"2017","journal-title":"Headache"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/jamaneurol.2014.133","article-title":"The idiopathic intracranial hypertension treatment trial: Clinical profile at baseline","volume":"71","author":"Wall","year":"2014","journal-title":"JAMA Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/14737175.2023.2206567","article-title":"Current and emerging diagnostic and management approaches for idiopathic intracranial hypertension","volume":"23","author":"Piccus","year":"2023","journal-title":"Expert Rev. Neurother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1111\/ene.12512","article-title":"The course of headache in idiopathic intracranial hypertension: A 12-month prospective follow-up study","volume":"21","author":"Yri","year":"2014","journal-title":"Eur. J. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1212\/01.WNL.0000066683.34093.E2","article-title":"Idiopathic intracranial hypertension: The prevalence and morphology of sinovenous stenosis","volume":"60","author":"Farb","year":"2003","journal-title":"Neurology"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Horev, A., Aharoni-Bar, S., Katson, M., Tsumi, E., Regev, T., Zlotnik, Y., Biederko, R., Ifergane, G., Shelef, I., and Eliav, T. (2024). Predictors of Headaches and Quality of Life in Women with Ophthalmologically Resolved Idiopathic Intracranial Hypertension. J. Clin. Med., 13.","DOI":"10.3390\/jcm13133971"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.wneu.2023.12.125","article-title":"Foundations of the Diagnosis and Management of Idiopathic Intracranial Hypertension and Pulsatile Tinnitus","volume":"184","author":"Pandey","year":"2024","journal-title":"World Neurosurg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1055\/s-0039-3399506","article-title":"Men Are from Mars, Idiopathic Intracranial Hypertension Is from Venous: The Role of Venous Sinus Stenosis and Stenting in Idiopathic Intracranial Hypertension","volume":"39","author":"Dinkin","year":"2019","journal-title":"Semin. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Midtlien, J.P., Kittel, C., Klever, L.A., Kiritsis, N.R., Aldridge, J.B., and Fargen, K.M. (2024). Redefining treatment expectations: Exploring mid- and long-term outcomes of venous sinus stenting in idiopathic intracranial hypertension. J. Neurointerv. Surg., epub ahead of print.","DOI":"10.1136\/jnis-2023-021336"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1177\/1971400918782320","article-title":"Transverse venous sinus stenting for idiopathic intracranial hypertension: Safety and feasibility","volume":"31","author":"Koovor","year":"2018","journal-title":"Neuroradiol. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e14356","DOI":"10.1111\/cns.14356","article-title":"Long-term efficacy of venous sinus stenting in the treatment of idiopathic intracranial hypertension","volume":"30","author":"Cheng","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref_21","first-page":"648","article-title":"Stenting for Venous Sinus Stenosis in Patients with Idiopathic Intracranial Hypertension: An Updated Systematic Review and Meta-Analysis of the Literature","volume":"94","author":"Lim","year":"2024","journal-title":"Neurosurgery"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejrad.2019.04.023","article-title":"Systematic review and meta-analysis of MRI signs for diagnosis of idiopathic intracranial hypertension","volume":"116","author":"Kwee","year":"2019","journal-title":"Eur. J. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.0b013e3182a55f17","article-title":"Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children","volume":"81","author":"Friedman","year":"2013","journal-title":"Neurology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jocn.2020.04.066","article-title":"The role of opening CSF pressure in response to treatment for idiopathic intracranial hypertension (IIH)","volume":"76","author":"Togha","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1038\/s41433-023-02569-x","article-title":"Longitudinal prospective cohort study evaluating prognosis in idiopathic intracranial hypertension patients with and without comorbid polycystic ovarian syndrome","volume":"37","author":"Thaller","year":"2023","journal-title":"Eye"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/head.13144","article-title":"The Idiopathic Intracranial Hypertension Treatment Trial: A Review of the Outcomes","volume":"57","author":"Smith","year":"2017","journal-title":"Headache"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Horev, A., Eliav, T., Sherer, I., Biederko, R., Ben-Arie, G., Shelef, I., Zlotnik, Y., Regev, T., Tsumi, E., and Honig, A. (2024). Radiological signs supporting idiopathic intracranial hypertension in symptomatic patients with lumbar puncture opening pressure <250 mm. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-70588-z"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/WCO.0000000000000885","article-title":"MRI findings as markers of idiopathic intracranial hypertension","volume":"34","author":"Barkatullah","year":"2021","journal-title":"Curr. Opin. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s10194-023-01641-x","article-title":"MRI features of idiopathic intracranial hypertension are not prognostic of visual and headache outcome","volume":"24","author":"Bsteh","year":"2023","journal-title":"J. Headache Pain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"120120","DOI":"10.1016\/j.jns.2021.120120","article-title":"Depression and generalized anxiety symptoms in idiopathic intracranial hypertension: Prevalence, under-reporting and effect on visual outcome","volume":"434","author":"Donaldson","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/head.14465","article-title":"Depression and anxiety in women with idiopathic intracranial hypertension compared to migraine: A matched controlled cohort study","volume":"63","author":"Mollan","year":"2023","journal-title":"Headache"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1468-1331.2009.02625.x","article-title":"Illness perceptions and quality of life amongst women with pseudotumor cerebri","volume":"16","author":"Kesler","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaclp.2023.10.005","article-title":"A Systematic Review of Neuropsychiatric Symptoms in Idiopathic Intracranial Hypertension","volume":"65","author":"Kosyakova","year":"2024","journal-title":"J. Acad. Consult.-Liaison Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/neurintsurg-2020-016124","article-title":"Quality of life, need for retreatment, and the re-equilibration phenomenon after venous sinus stenting for idiopathic intracranial hypertension","volume":"13","author":"Garner","year":"2021","journal-title":"J. Neurointerv. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1177\/0333102411423305","article-title":"Is cerebrospinal fluid shunting in idiopathic intracranial hypertension worthwhile? A 10-year review","volume":"31","author":"Sinclair","year":"2011","journal-title":"Cephalalgia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/08820538.2017.1353810","article-title":"Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension","volume":"33","author":"Gilbert","year":"2018","journal-title":"Semin. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.3174\/ajnr.A4377","article-title":"Meta-Analysis of CSF Diversion Procedures and Dural Venous Sinus Stenting in the Setting of Medically Refractory Idiopathic Intracranial Hypertension","volume":"36","author":"Satti","year":"2015","journal-title":"AJNR Am. J. Neuroradiol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/22\/2572\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:33:19Z","timestamp":1760113999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/22\/2572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,15]]},"references-count":37,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["diagnostics14222572"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14222572","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,15]]}}}