{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:38:44Z","timestamp":1768001924558,"version":"3.49.0"},"reference-count":9,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>We present the case of a 60-year-old male with recurrent atypical meningioma in the right parietal lobe, previously treated with surgery and radiation therapy. Magnetic resonance imaging (MRI) performed 5 years after radiation therapy suggested a possible recurrence. A somatostatin receptor positron emission tomography\/computed tomography (SR-PET\/CT) scan with Gallium-68 DOTATATE was performed to confirm this suspicion. SR-PET\/CT confirmed the presence of recurrent meningioma, showing a novel \u201crosary sign\u201d with multiple adjacent areas of focal tracer uptake along the resection margins of the previous surgical site in the right parietal region. This novel imaging pattern improved diagnostic accuracy by detailing disease extent and identifying additional lesions not visible via MRI. Given the failure of prior treatments and high SR expression, peptide receptor radionuclide therapy (PRRT) was proposed as a therapeutic option for the patient.<\/jats:p>","DOI":"10.3390\/diagnostics14222608","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:46:11Z","timestamp":1732164371000},"page":"2608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cRosary Sign\u201d at Somatostatin Receptor PET in a Case of Recurrent Meningioma"],"prefix":"10.3390","volume":"14","author":[{"given":"Cesare Michele","family":"Iacovitti","sequence":"first","affiliation":[{"name":"Division of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-1281","authenticated-orcid":false,"given":"Davide Giovanni","family":"Bosetti","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Muoio","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-562X","authenticated-orcid":false,"given":"Marco","family":"Cuzzocrea","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2864-5364","authenticated-orcid":false,"given":"Gaetano","family":"Paone","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland"},{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-780X","authenticated-orcid":false,"given":"Giorgio","family":"Treglia","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland"},{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, 6900 Lugano, Switzerland"},{"name":"Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1007\/s00259-024-06783-x","article-title":"Joint EANM\/EANO\/RANO\/SNMMI practice guideline\/procedure standards for diagnostics and therapy (theranostics) of meningiomas using radiolabeled somatostatin receptor ligands: Version 1.0","volume":"51","author":"Albert","year":"2024","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Filippi, L., Palumbo, I., Bagni, O., Schillaci, O., Aristei, C., and Palumbo, B. (2022). Somatostatin Receptor Targeted PET-Imaging for Diagnosis, Radiotherapy Planning and Theranostics of Meningiomas: A Systematic Review of the Literature. Diagnostics, 12.","DOI":"10.3390\/diagnostics12071666"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2967\/jnumed.120.249607","article-title":"Somatostatin Receptor-Targeted Radiopeptide Therapy in Treatment-Refractory Meningioma: Individual Patient Data Meta-analysis","volume":"62","author":"Mirian","year":"2021","journal-title":"J. Nucl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Palmisciano, P., Watanabe, G., Conching, A., Ogasawara, C., Ferini, G., Bin-Alamer, O., Haider, A.S., Sabini, M.G., Cuttone, G., and Cosentino, S. (2022). The Role of [\u2076\u2078Ga]Ga-DOTA-SSTR PET Radiotracers in Brain Tumors: A Systematic Review of the Literature and Ongoing Clinical Trials. Cancers, 14.","DOI":"10.3390\/cancers14122925"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Treglia, G., Raditchkova, M., Giovanella, L., Stelmes, J.J., Bosetti, D.G., and Martucci, F. (2021). Two Birds with One Stone: Skull Base Meningioma and Jugulotympanic Paragangliomas with Somatostatin Receptor Positron Emission Tomography. Diagnostics, 11.","DOI":"10.3390\/diagnostics11091669"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Helgebostad, R., Revheim, M.E., Johnsrud, K., Amlie, K., Alavi, A., and Connelly, J.P. (2022). Clinical Applications of Somatostatin Receptor (Agonist) PET Tracers beyond Neuroendocrine Tumors. Diagnostics, 12.","DOI":"10.3390\/diagnostics12020528"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Muoio, B., Espeli, V., and Treglia, G. (2023). Neuro-Oncology and Positron Emission Tomography: \u201cJust Can\u2019t Get Enough\u201d. Cancers, 15.","DOI":"10.3390\/cancers15194739"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Albano, D., Treglia, G., Dondi, F., and Bertagna, F. (2022). Prevalence of Brain Incidental Lesions Detected by 68Ga-DOTA Peptides PET\/CT. Medicina, 58.","DOI":"10.3390\/medicina58070916"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Treglia, G., Muoio, B., Trevisi, G., Mattoli, M.V., Albano, D., Bertagna, F., and Giovanella, L. (2019). Diagnostic Performance and Prognostic Value of PET\/CT with Different Tracers for Brain Tumors: A Systematic Review of Published Meta-Analyses. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194669"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/22\/2608\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:36:21Z","timestamp":1760114181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/22\/2608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":9,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["diagnostics14222608"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14222608","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]}}}