{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:36:42Z","timestamp":1760146602543,"version":"build-2065373602"},"reference-count":9,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cytomegalovirus (CMV) is a common cause of infection in immunocompromised individuals, such as patients with hematological malignancies or AIDS, but can also occur in patients with other acquired immunodeficiencies. In tissue-invasive diseases, CMV diagnosis requires CMV DNA in the plasma and the histological confirmation of CMV in a tissue or organ. Evidence of CMV colitis requires a characteristic endoscopic picture with ulcers with a well-defined, convex appearance and CMV viral inclusions in the form of an \u201cowl\u2019s eye\u201d on mucosal sections stained with hematoxylin and eosin. CMV-specific immunohistochemistry is the gold standard for identifying CMV in tissue biopsies. It is important to consider a CMV infection in the diagnostic process, as it may delay the diagnosis and the treatment. We present the case of a 78-year-old patient with amiodarone interstitial lung disease who was treated with methylprednisolone. Two weeks after the start of his treatment, he was admitted to the hospital for acute gastroenterocolitis and Addisonian crisis. An examination had confirmed a tissue-invasive CMV disease. He was treated with valganciclovir for a total of six weeks. After the completion of treatment, the patient showed no clinical signs of CMV infection, and both laboratory and histological examinations revealed no residual CMV disease. Tissue-invasive CMV disease can occur in patients with acquired immunodeficiency, which may result from various causes, including glucocorticoid treatment.<\/jats:p>","DOI":"10.3390\/diagnostics14232633","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T10:17:23Z","timestamp":1732270643000},"page":"2633","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytomegalovirus Enterocolitis in a Patient Treated with Methylprednisolone for Amiodarone Hypersensitivity Pneumonitis"],"prefix":"10.3390","volume":"14","author":[{"given":"Darinka","family":"Purg","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000 Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Hojnik","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000 Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-6027","authenticated-orcid":false,"given":"Nika Aleksandra","family":"Kravos Tram\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000 Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11894-008-0077-9","article-title":"Gastrointestinal cytomegalovirus disease in the immunocompromised patient","volume":"10","author":"Baroco","year":"2008","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.5858\/arpa.2015-0176-RS","article-title":"Cytomegalovirus Colitis: An Uncommon Mimicker of Common Colitides","volume":"140","author":"Baniak","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2174\/187152611796504773","article-title":"Cytomegalovirus infections in non-immunocompromised and immunocompromised patients in the intensive care unit","volume":"11","author":"Florescu","year":"2011","journal-title":"Infect. Disord. Drug Targets"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10140-020-01750-z","article-title":"Clinical, imaging, endoscopic findings, and management of patients with CMV colitis: A single-institute experience","volume":"27","author":"Shieh","year":"2020","journal-title":"Emerg. Radiol."},{"key":"ref_5","unstructured":"Azer, S.A., and Limaiem, F. (2024). Cytomegalovirus Colitis. StatPearls, StatPearls Publishing."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11908-019-0664-y","article-title":"Diagnosis and Management of CMV Colitis","volume":"21","author":"Padlipsky","year":"2019","journal-title":"Curr. Infect. Dis. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.humpath.2016.09.009","article-title":"Cytomegalovirus (CMV) in gastrointestinal mucosal biopsies: Should a pathologist perform CMV immunohistochemistry if the clinician requests it?","volume":"60","author":"Upton","year":"2017","journal-title":"Hum. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.5858\/arpa.2020-0425-OA","article-title":"The Trends of Immunohistochemistry for Tissue-Invasive Cytomegalovirus in Gastrointestinal Mucosal Biopsies","volume":"146","author":"Goyal","year":"2022","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ajt.12006","article-title":"CMV: Prevention, Diagnosis and Therapy","volume":"13","author":"Kotton","year":"2013","journal-title":"Am. J. Transplant."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/23\/2633\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:37:47Z","timestamp":1760114267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/23\/2633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,22]]},"references-count":9,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["diagnostics14232633"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14232633","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2024,11,22]]}}}