{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:53Z","timestamp":1787027933230,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"U.S. Army Medical Research and Development Command, Combat Casualty Care and Military Infection Disease Research Programs","award":["P_10_2020_USAISR"],"award-info":[{"award-number":["P_10_2020_USAISR"]}]},{"name":"U.S. Army Medical Research and Development Command, Combat Casualty Care and Military Infection Disease Research Programs","award":["CO220019"],"award-info":[{"award-number":["CO220019"]}]},{"name":"U.S. Army Medical Research and Development Command, Combat Casualty Care and Military Infection Disease Research Programs","award":["MI220039"],"award-info":[{"award-number":["MI220039"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Blood lactate concentration is often used to assess systemic hypoperfusion, tissue hypoxia, and sepsis in trauma patients and serves as a prognostic indicator and marker of response to therapy. Point-of-care (POC) devices provide rapid lactate measurements with a single drop of blood. In this study, lactate values from whole blood, measured with two POC devices, Abbott i-STAT\u00ae and the Nova Biomedical Lactate (LA) Plus\u2122 meter, are compared. Methods: An observational analysis of 760 blood samples from four preclinical trauma animal models was performed. Lactate was measured simultaneously with two POC devices (i-STAT\u00ae and the Lactate Plus\u2122 meter). The evaluation in the form of a Bland\u2013Altman diagram showed the agreement of the tests. Results: The Spearman correlation was 0.9180 (95% CI 0.9056 to 0.9288) for i-STAT\u00ae vs. the LA Plus\u2122 meter. Both tests showed a significant increase in lactate after injury (p &lt; 0.05). The i-STAT\u00ae showed a small bias compared to the LA Plus\u2122 meter (\u22120.0227 \u00b1 0.4542 with 95% limits of agreement from \u22120.09129 to 0.8675). The LA Plus\u2122 meter showed slightly higher values overall (0.0227 mmol\/L), but the i-STAT\u00ae showed higher results at lactate levels above 2.5 mmol\/L. Conclusions: The observed similarity in performance between the two devices suggests that both are capable of reliably measuring lactate levels in a trauma situation. The LA Plus\u2122 meter provides fast results with only one drop of blood. This study supports the prehospital use of POC devices.<\/jats:p>","DOI":"10.3390\/diagnostics14232641","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T05:21:32Z","timestamp":1732512092000},"page":"2641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Observational Analysis of Point-of-Care Lactate Plus\u2122 Meter in Preclinical Trauma Models"],"prefix":"10.3390","volume":"14","author":[{"given":"Catharina","family":"Gaeth","sequence":"first","affiliation":[{"name":"Combat Wound Care, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, Houston, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila","family":"Duarte","sequence":"additional","affiliation":[{"name":"Combat Wound Care, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, Houston, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Combat Wound Care, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, Houston, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Powers","sequence":"additional","affiliation":[{"name":"Combat Wound Care, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, Houston, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6000-3524","authenticated-orcid":false,"suffix":"II","given":"Randolph","family":"Stone","sequence":"additional","affiliation":[{"name":"Combat Wound Care, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA Fort Sam Houston, Houston, TX 78234, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5326\/JAAHA-MS-5700","article-title":"Comparison of two portable lactate meters in dogs","volume":"49","author":"Karagiannis","year":"2013","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: The ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1056\/NEJMra1208943","article-title":"Circulatory shock","volume":"369","author":"Vincent","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1053\/j.tcam.2016.05.004","article-title":"Point of Care Measurement of Lactate","volume":"31","author":"Schoeffler","year":"2016","journal-title":"Top. Companion Anim. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1365-2044.1984.tb06516.x","article-title":"The relative prognostic value of lactate and haemodynamic measurements in early shock","volume":"39","author":"Cowan","year":"1984","journal-title":"Anaesthesia"},{"key":"ref_6","first-page":"637","article-title":"Normalization of blood lactate as early end-point of polytrauma treatment","volume":"114","author":"Galkova","year":"2013","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"R242","DOI":"10.1186\/cc10497","article-title":"Dynamic lactate indices as predictors of outcome in critically ill patients","volume":"15","author":"Nichol","year":"2011","journal-title":"Crit. Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/01.ta.0000205858.82575.55","article-title":"Admission Serum Lactate Levels Do Not Predict Mortality in the Acutely Injured Patient","volume":"60","author":"Pal","year":"2006","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00068-012-0212-z","article-title":"Serial lactate and admission SOFA scores in trauma: An analysis of predictive value in 724 patients with and without traumatic brain injury","volume":"39","author":"Billeter","year":"2013","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_10","first-page":"e28200","article-title":"The Association between Serum Lactate Concentration, Base Deficit, and Mortality in Polytrauma Patients as a Prognostic Factor: An Observational Study","volume":"14","author":"Jyoti","year":"2022","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"21501327211000233","DOI":"10.1177\/21501327211000233","article-title":"A Point-of-Care Serum Lactate Level and Mortality in Adult Sepsis Patients: A Community Hospital Setting","volume":"12","author":"Charoentanyarak","year":"2021","journal-title":"J. Prim. Care Community Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/TA.0000000000000549","article-title":"A comparison of prehospital lactate and systolic blood pressure for predicting the need for resuscitative care in trauma transported by ground","volume":"78","author":"Guyette","year":"2015","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e22885","DOI":"10.1002\/jcla.22885","article-title":"Comparison of point-of-care and central laboratory analyzers for blood gas and lactate measurements","volume":"33","author":"Indrasari","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4266\/acc.2019.00780","article-title":"Inclusion of lactate level measured upon emergency room arrival in trauma outcome prediction models improves mortality prediction: A retrospective, single-center study","volume":"35","author":"Moon","year":"2020","journal-title":"Acute Crit. Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e859","DOI":"10.3399\/bjgp17X693665","article-title":"Point-of-care lactate testing for sepsis at presentation to health care: A systematic review of patient outcomes","volume":"67","author":"Morris","year":"2017","journal-title":"Br. J. Gen. Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e001899","DOI":"10.1136\/bmjopen-2012-001899","article-title":"A method-comparison study regarding the validity and reliability of the Lactate Plus analyzer","volume":"3","author":"Hart","year":"2013","journal-title":"BMJ Open"},{"key":"ref_17","unstructured":"Abbott Point of Care, Inc (2024, May 06). i-STAT CG4+ Cartridge. Available online: https:\/\/www.globalpointofcare.abbott\/us\/en\/product-details\/apoc\/istat-cg4plus.html."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.clinbiochem.2016.11.004","article-title":"Analytical performance of three whole blood point-of-care lactate devices compared to plasma lactate comparison methods and a flow-injection mass spectrometry method","volume":"50","author":"Tolan","year":"2017","journal-title":"Clin. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s10877-022-00812-6","article-title":"Accuracy of a point-of-care blood lactate measurement device in a prehospital setting","volume":"36","author":"Walther","year":"2022","journal-title":"J. Clin. Monit. Comput."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/j.jepm.2023.03.002","article-title":"Comparison of two point of care lactate instruments in guinea pigs (Cavia porcellus)","volume":"46","author":"Levy","year":"2023","journal-title":"J. Exot. Pet. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00421-010-1379-9","article-title":"Evaluation of three portable blood lactate analysers: Lactate Pro, Lactate Scout and Lactate Plus","volume":"109","author":"Tanner","year":"2010","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.clinbiochem.2018.03.006","article-title":"Lactate POCT in mobile intensive care units for septic patients? A comparison of capillary blood method versus venous blood and plasma-based reference methods","volume":"55","author":"Jouffroy","year":"2018","journal-title":"Clin. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jamcollsurg.2010.01.012","article-title":"Lactate is a better predictor than systolic blood pressure for determining blood requirement and mortality: Could prehospital measures improve trauma triage?","volume":"210","author":"Vandromme","year":"2010","journal-title":"J. Am. Coll. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1309\/HBQEFDPH34MKK5GP","article-title":"Comparison of lactate values between point-of-care and central laboratory analyzers","volume":"128","author":"Karon","year":"2007","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/TA.0000000000001192","article-title":"Prehospital point-of-care lactate following trauma: A systematic review","volume":"81","author":"Lewis","year":"2016","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s00068-023-02226-8","article-title":"The potential of point-of-care diagnostics to optimise prehospital trauma triage: A systematic review of literature","volume":"49","author":"Stojek","year":"2023","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_28","first-page":"782","article-title":"Prehospital serum lactate as a predictor of outcomes in trauma patients: A retrospective observational study","volume":"70","author":"Guyette","year":"2011","journal-title":"J. Trauma"},{"key":"ref_29","first-page":"203","article-title":"Reliability and accuracy of six hand-held blood lactate analysers","volume":"14","author":"Bonaventura","year":"2015","journal-title":"J. Sports Sci. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0002-9610(97)89552-9","article-title":"Serial blood lactate levels can predict the development of multiple organ failure following septic shock","volume":"171","author":"Bakker","year":"1996","journal-title":"Am. J. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1017\/S1049023X23006623","article-title":"The Effectiveness of Prehospital Subcutaneous Continuous Lactate Monitoring in Adult Trauma: A Systematic Review","volume":"39","author":"Scriven","year":"2024","journal-title":"Prehosp. Disaster Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/PEC.0b013e318294ddb1","article-title":"Diagnostic accuracy of a single point-of-care prehospital serum lactate for predicting outcomes in pediatric trauma patients","volume":"29","author":"Shah","year":"2013","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/TA.0000000000001085","article-title":"Prehospital lactate improves accuracy of prehospital criteria for designating trauma activation level","volume":"81","author":"Brown","year":"2016","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.cll.2015.05.006","article-title":"Use of Lactate in Small Animal Clinical Practice","volume":"35","author":"Sharkey","year":"2015","journal-title":"Clin. Lab. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/SHK.0000000000000096","article-title":"Challenges and possibilities in forward resuscitation","volume":"41","author":"Hooper","year":"2014","journal-title":"Shock"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13049-020-00776-z","article-title":"Validation of a point-of-care capillary lactate measuring device (Lactate Pro 2)","volume":"28","author":"Raa","year":"2020","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Lee, S., Song, J., Lee, S., Kim, S.J., Han, K.S., and Lee, S. (2024). Impact of Point-of-Care Lactate Testing for Sepsis on Bundle Adherence and Clinical Outcomes in the Emergency Department: A Pre-Post Observational Study. J. Clin. Med., 13.","DOI":"10.3390\/jcm13185389"},{"key":"ref_38","unstructured":"Nova Biomedical Corporation, Waltham, MA, USA (2024, May 06). Lactate Plus Meter: Blood Lactate Meter Optimizes Endurance Training and Conditioning Fast, Virtually Painless Lactate Testing. Available online: https:\/\/www.novabiomedical.com\/lactate-plus\/."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/23\/2641\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:38:02Z","timestamp":1760114282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/23\/2641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,23]]},"references-count":38,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["diagnostics14232641"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14232641","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,23]]}}}