{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:37:30Z","timestamp":1760146650293,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Introduction: Lesion load (LL), deep gray matter (DGM) and normal-appearing white matter (NAWM) susceptibility and morphometry may help in monitoring brain changes in multiple sclerosis (MS) patients. We aimed at evaluating the feasibility of a fully automated segmentation and the potential interrelation between these biomarkers and clinical disability. Methods: Sixty-six patients with brain MRIs and clinical evaluations (Expanded Disability Status Scale [EDSS]) were retrospectively included. Automated prototypes were used for the segmentation and morphometry of brain regions (MorphoBox) and MS lesions (LeManPV). Susceptibility maps were estimated using standard post-processing (RESHARP and TVSB). Spearman\u2019s rho was computed to evaluate the interrelation between biomarkers and EDSS. Results: We found (i) anticorrelations between the LL and right thalamus susceptibility (rho = \u22120.46, p &lt; 0.001) and between the LL and NAWM susceptibility (rho = [\u22120.68 to \u22120.25], p \u2264 0.05); (ii) an anticorrelation between LL and DGM (rho = [\u22120.71 to \u22120.36], p &lt; 0.04) and WM morphometry (rho = [\u22120.64 to \u22120.28], p \u2264 0.01); and (iii) a positive correlation between EDSS and LL (rho = [0.28 to 0.5], p \u2264 0.03) and anticorrelation between EDSS and NAWM susceptibility (rho = [\u22120.29 to \u22120.38], p &lt; 0.014). Conclusions: Fully automated brain morphometry and susceptibility monitoring is feasible in MS patients. The lesion load, thalamus and NAWM susceptibility values and trophicity are interrelated and correlate with disability.<\/jats:p>","DOI":"10.3390\/diagnostics14232669","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:20:12Z","timestamp":1732681212000},"page":"2669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Automated Quantitative Susceptibility and Morphometry MR Study: Feasibility and Interrelation Between Clinical Score, Lesion Load, Deep Grey Matter and Normal-Appearing White Matter in Multiple Sclerosis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-599X","authenticated-orcid":false,"given":"Gibran","family":"Manasseh","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Hilbert","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"},{"name":"Advanced Clinical Imaging Technology, Siemens Healthcare AG, 1015 Lausanne, Switzerland"},{"name":"Signal Processing Laboratory (LTS5), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio Jo\u00e3o","family":"Fartaria","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"},{"name":"Advanced Clinical Imaging Technology, Siemens Healthcare AG, 1015 Lausanne, Switzerland"},{"name":"Signal Processing Laboratory (LTS5), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Deverdun","sequence":"additional","affiliation":[{"name":"I2FH, Institut d\u2019Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meritxell Bach","family":"Cuadra","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"},{"name":"CIBM Center of Biomedical Imaging, 1015 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-2854","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Mar\u00e9chal","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"},{"name":"Advanced Clinical Imaging Technology, Siemens Healthcare AG, 1015 Lausanne, Switzerland"},{"name":"Signal Processing Laboratory (LTS5), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-9456","authenticated-orcid":false,"given":"Tobias","family":"Kober","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"},{"name":"Advanced Clinical Imaging Technology, Siemens Healthcare AG, 1015 Lausanne, Switzerland"},{"name":"Signal Processing Laboratory (LTS5), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1015 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9897-4561","authenticated-orcid":false,"given":"Vincent","family":"Dunet","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1148\/radiol.2403050569","article-title":"Whole-Brain T1 Mapping in Multiple Sclerosis: Global Changes of Normal-appearing Gray and White Matter","volume":"240","author":"Vrenken","year":"2006","journal-title":"Radiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/mrm.25420","article-title":"Quantitative Susceptibility Mapping (Qsm) of White Matter Multiple Sclerosis Lesions: Interpreting Positive Susceptibility and the Presence of Iron","volume":"74","author":"Wisnieff","year":"2015","journal-title":"Magn. 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