{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:52:38Z","timestamp":1789588358892,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Guangzhou","award":["202201010798"],"award-info":[{"award-number":["202201010798"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The mechanism of aneurysm wall enhancement (AWE) in middle cerebral artery (MCA) bifurcation aneurysms on vessel wall magnetic resonance imaging (VW-MRI) remains unclear. We aimed to explore the morphologically related hemodynamic mechanism for the AWE of MCA bifurcation aneurysms. Methods: Patients with unruptured MCA bifurcation aneurysms undergoing VW-MRI were enrolled. Logistic regression analyses were performed to determine the risk factors for AWE. Based on the results of retrospective analyses, bifurcation aneurysm silicone models with a specific aspect ratio (AR) were designed and underwent VW-MRI with different inlet velocities. Computational fluid dynamics (CFD) analyses were conducted on both silicone models and patients\u2019 aneurysms. Results: A total of 104 aneurysms in 95 patients (mean age 60; 34 males) were included for baseline analysis and morphological analysis. Logistic regression analysis indicated AR (OR, 5.92; 95% CI, 2.00\u201317.55; p = 0.001) was associated with AWE. In the high-AR group of 45 aneurysms with AWE, the aneurysm sac exhibited lower blood flow velocity, lower wall shear stress, a larger proportion of low-flow regions and higher wall enhancement values. In total, 15 silicone models were analyzed, divided into three subgroups based on neck width (4 mm, 6 mm, and 8 mm). Each subgroup contained aneurysms with five different ARs: 1.0, 1.25, 1.5, 1.75, and 2.0. In silicone models, contrast enhancement (CE) was mainly located beneath the dome of the aneurysm wall. With the same inlet velocity, CE gradually increased as the AR increased. Similarly, at the same AR, CE increased as the inlet velocity decreased. CFD demonstrated a moderate positive correlation between the near-wall enhancement index and the ratio of the low-velocity area (r = 0.6672, p &lt; 0.001). Conclusions: The AR is associated with the AWE of MCA bifurcation aneurysms. A high AR may promote wall enhancement by causing near-wall slow flow.<\/jats:p>","DOI":"10.3390\/diagnostics14232722","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T09:18:32Z","timestamp":1733217512000},"page":"2722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Near-Wall Slow Flow Contributes to Wall Enhancement of Middle Cerebral Artery Bifurcation Aneurysms on Vessel Wall MRI"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-4193","authenticated-orcid":false,"given":"Linfeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiewei","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-5670","authenticated-orcid":false,"given":"Feng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou 510060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1056\/NEJMoa1113260","article-title":"The natural course of unruptured cerebral aneurysms in a Japanese cohort","volume":"366","author":"Morita","year":"2012","journal-title":"N. 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