{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:38:48Z","timestamp":1760146728198,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Gastric duplication cysts (GDCs) are rare congenital anomalies, often identified during infancy or childhood. Although typically benign, there have been sporadic reports of malignant transformations, including adenocarcinoma and rare mixed tumors. Herein, we describe a rare case of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma occurring within a GDC in a 54-year-old Korean woman with a history of melena and hematemesis. Initial gastroscopy and positron emission tomography\u2013computed tomography (PET-CT) revealed a protruding stomach mass. A laparoscopic total gastrectomy was performed, and histological examination confirmed a mixed carcinoma originating from an ectopic pancreas within the duplication cyst. This case is unique as it is the first reported instance in the world of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma arising from an ectopic pancreas within a GDC. This highlights the importance of considering pancreatobiliary-type adenocarcinoma in the differential diagnosis of malignancies originating from GDCs, which has implications for treatment strategies.<\/jats:p>","DOI":"10.3390\/diagnostics14232727","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T04:47:22Z","timestamp":1733287642000},"page":"2727","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mixed Pancreatobiliary Ductal Adenocarcinoma and Squamous Cell Carcinoma Arising from an Ectopic Pancreas in a Gastric Duplication Cyst\u2014A Rare Double Diagnosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Minhye","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pathology, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"},{"name":"Department of Pathology, Gyeongsang National University School of Medicine, Jinju 52727, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungwook","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"},{"name":"Department of Pathology, Gyeongsang National University School of Medicine, Jinju 52727, Republic of Korea"},{"name":"Institute of Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daehyun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gyeongsang National University School of Medicine, Jinju 52727, Republic of Korea"},{"name":"Institute of Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea"},{"name":"Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyojung","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gyeongsang National University School of Medicine, Jinju 52727, Republic of Korea"},{"name":"Institute of Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea"},{"name":"Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon 51472, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongchul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"},{"name":"Department of Pathology, Gyeongsang National University School of Medicine, Jinju 52727, Republic of Korea"},{"name":"Institute of Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref_1","first-page":"57","article-title":"Gastric duplication cyst with respiratory epithelium: An uncommon injury that has a difficult differential diagnosis","volume":"97","year":"2019","journal-title":"Cir. 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