{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:14:22Z","timestamp":1790054062982,"version":"4.0.1"},"reference-count":36,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objectives: Fournier\u2019s gangrene is an aggressive, rapidly progressing, and life-threatening necrotizing fasciitis of the perineal and genital regions. Various scoring systems have been developed for predicting survival and prognosis in Fournier\u2019s gangrene. This retrospective study aimed to evaluate the effectiveness of the newly developed Fournier\u2019s gangrene mortality index (FGMI) in predicting mortality associated with Fournier\u2019s gangrene. Methods: The study included patients over the age of 18 years who were followed-up with a diagnosis of Fournier\u2019s gangrene in the general surgery clinics of three different hospitals in \u015eanl\u0131urfa province between 2014 and 2024. The patients included in this study were divided into two groups: deceased (n = 20) and surviving (n = 149). In FGMI, the parameters used were age, creatinine level, albumin level, lymphocyte percentage, and neutrophil-to-lymphocyte ratio. Based on the total score and risk assessment, &lt;5 points were categorized as low-to-moderate mortality risk and \u22655 points as high mortality risk. Results: A total of 169 patients with a diagnosis of Fournier\u2019s gangrene were included in the study; 87 were men (51.48%). The median age of all patients was 53 (40\u201363) years; 20 patients (11.8%) died. The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score did not show a statistically significant difference between the deceased and surviving groups (p = 0.5). Compared to the survivors, the deceased had higher neutrophil counts, neutrophil percentages, neutrophil-to-lymphocyte ratios, platelet-to-lymphocyte ratios, and C-reactive protein-to-albumin ratios, whereas lymphocyte counts, lymphocyte percentages, eosinophil counts, eosinophil percentages, monocyte counts, and monocyte percentages were lower, and these differences were statistically significant. According to receiver operating characteristic (ROC) analysis, the ROC-area under the curve for predicting mortality based on an FGMI score of \u22655 was 0.88 (95% CI: 0.80\u20130.95) with a sensitivity of 90% and a specificity of 70% (p &lt; 0.001). Univariate risk analysis was performed, and the odds ratio revealed that mortality risk in patients followed-up for Fournier\u2019s gangrene with a FGMI score of \u22655 was 20 times higher (4.48\u201390.91) (p &lt; 0.001). Conclusions: The results reveal that the FGMI score is a scoring system that can predict mortality at the initial clinical presentation of patients with Fournier\u2019s gangrene. Another important finding of the present study is that the LRINEC score was not sufficiently effective in predicting mortality.<\/jats:p>","DOI":"10.3390\/diagnostics14232732","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T06:24:44Z","timestamp":1733379884000},"page":"2732","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fournier\u2019s Gangrene Mortality Index (FGMI): A New Scoring System for Predicting Fournier\u2019s Gangrene Mortality"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-1773","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Y\u00f6nder","sequence":"first","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Harran University, \u015eanl\u0131urfa 63300, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Harran University, \u015eanl\u0131urfa 63300, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Sait","family":"Berhuni","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Harran University, \u015eanl\u0131urfa 63300, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-707X","authenticated-orcid":false,"given":"Ahmed Cihad","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sakarya Training and Research Hospital, Sakarya 54290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Elkan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Harran University, \u015eanl\u0131urfa 63300, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faik","family":"Tatl\u0131","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Harran University, \u015eanl\u0131urfa 63300, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"\u00d6zg\u00f6n\u00fcl","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Harran University, \u015eanl\u0131urfa 63300, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-7121","authenticated-orcid":false,"given":"Felat","family":"\u00c7ift\u00e7i","sequence":"additional","affiliation":[{"name":"Clinic of General Surgery, \u015eanl\u0131urfa Training and Research Hospital, \u015eanl\u0131urfa 63250, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7102-8973","authenticated-orcid":false,"given":"F\u0131rat","family":"Erkmen","sequence":"additional","affiliation":[{"name":"Clinic of General Surgery, \u015eanl\u0131urfa Bal\u0131kl\u0131g\u00f6l State Hospital, \u015eanl\u0131urfa 63050, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1514-1685","authenticated-orcid":false,"given":"O\u011fuz","family":"Karabay","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sakarya University, Sakarya 54290, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Uzunk\u00f6y","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Faculty of Medicine, Harran University, \u015eanl\u0131urfa 63300, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.21037\/tau.2019.03.09","article-title":"Fournier\u2019s gangrene: A modern analysis of predictors of outcomes","volume":"8","author":"Sparenborg","year":"2019","journal-title":"Transl. 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