{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:38:53Z","timestamp":1787027933298,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Vasoactive inotrope score, renal score, fibrosis-5 index, and lactate-albumin ratio have not been investigated before in determining multiple organ dysfunctions accompanying infants with hypoxic\u2013ischemic encephalopathy (HIE) in neonatal intensive care units (NICUs). The aim of this study was to determine whether multiple organ dysfunctions that may accompany HIE in infants are correlated with vasoactive inotrope score (VIS), renal score (RS), fibrosis-5 index (FIB-5), and lactate-albumin ratio (LAR), and whether these parameters can predict morbidity and mortality. Methods: This is a retrospective study, and 106 newborns diagnosed with HIE and treated with hypothermia were included in the study. Vasoactive inotrope score for cardiac dysfunction, renal score for renal dysfunction, fibrosis-5 index, and lactate\/albumin ratio for hepatic dysfunction were evaluated. Results: We found that the vasoactive inotrope score, renal score, fibrosis-5 index, and lactate-albumin ratio values of infants diagnosed with HIE are associated with cardiac, renal, and hepatic dysfunction. These values, calculated on the 2nd postnatal day, are particularly linked to prolonged hospital stay and mortality, which are key prognostic factors. Conclusions: Our study is the first to combine vasoactive inotrope score, renal score, fibrosis-5 index, and lactate-albumin ratio parameters in determining organ dysfunction in newborns with hypoxic\u2013ischemic encephalopathy and to reveal their prognostic and mortality prediction values. Therefore, although it offers new perspectives, new studies are needed.<\/jats:p>","DOI":"10.3390\/diagnostics14242796","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T09:38:15Z","timestamp":1733996295000},"page":"2796","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosis of Multiple Organ Dysfunction in Neonates with Hypoxic\u2013Ischemic Encephalopathy: Vasoactive Inotropic Score, Renal Score, Fibrosis-5 Index and Lactate\/Albumin Ratio"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-1174","authenticated-orcid":false,"given":"Ba\u015fak","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Neonatology, Dr. Sami Ulus Maternity and Child Research and Training Hospital, Babur st., Number: 36, Alt\u0131ndag 06080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-1496","authenticated-orcid":false,"given":"Hasan","family":"Akduman","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Dr. Sami Ulus Maternity and Child Research and Training Hospital, Babur st., Number: 36, Alt\u0131ndag 06080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Dilli","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Dr. Sami Ulus Maternity and Child Research and Training Hospital, Babur st., Number: 36, Alt\u0131ndag 06080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7409-0487","authenticated-orcid":false,"given":"Nilden","family":"\u00dcnsal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dr. Sami Ulus Maternity and Child Research and Training Hospital, Babur st., Number: 36, Alt\u0131ndag 06080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan Dinlen","family":"Fettah","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Dr. Sami Ulus Maternity and Child Research and Training Hospital, Babur st., Number: 36, Alt\u0131ndag 06080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015feg\u00fcl","family":"Zenciro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Dr. Sami Ulus Maternity and Child Research and Training Hospital, Babur st., Number: 36, Alt\u0131ndag 06080, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13760-020-01308-3","article-title":"Pathophysiology of hypoxic-ischemic encephalopathy: A review of the past and a view on the future","volume":"120","author":"Greco","year":"2020","journal-title":"Acta Neurol. Belg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41420-024-02014-2","article-title":"Regulated cell death in hypoxic-ischaemic encephalopathy: Recent development and mechanistic overview","volume":"10","author":"Wu","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.clp.2024.04.008","article-title":"Long-Term Outcomes Following Hypoxic Ischemic Encephalopathy","volume":"51","author":"Huntingford","year":"2024","journal-title":"Clin. Perinatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nurx.2006.01.007","article-title":"Hypothermic neuroprotection","volume":"3","author":"Gunn","year":"2006","journal-title":"NeuroRx"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000353948","article-title":"Time is brain: Starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns","volume":"104","author":"Thoresen","year":"2013","journal-title":"Neonatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/archdischild-2011-300716","article-title":"Cooling and seizure burden in term neonates: An observational study","volume":"97","author":"Low","year":"2012","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ped.12747","article-title":"Comparison of selective head cooling versus whole-body cooling","volume":"58","author":"Celik","year":"2016","journal-title":"Pediatr. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/jp.2017.164","article-title":"Prospective research on infants with mild encephalopathy: The PRIME study","volume":"38","author":"Prempunpong","year":"2018","journal-title":"J. Perinatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s41390-018-0174-x","article-title":"Prospective research in infants with mild encephalopathy identified in the first six hours of life: Neurodevelopmental outcomes at 18\u201322 months","volume":"84","author":"Chalak","year":"2018","journal-title":"Pediatr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e20160659","DOI":"10.1542\/peds.2016-0659","article-title":"Early EEG grade and outcome at 5 years after mild neonatal hypoxic ischemic encephalopathy","volume":"138","author":"Murray","year":"2016","journal-title":"Pediatrics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.earlhumdev.2018.02.007","article-title":"Mild hypoxic ischaemic encephalopathy and longterm neurodevelopmental outcome\u2014A systematic review","volume":"120","author":"Conway","year":"2018","journal-title":"Early Hum. Dev."},{"key":"ref_12","first-page":"184","article-title":"The effect of hypoxic ischemic encephalopathy towards multi-organ complications and its early outcome at a Malaysian district hospital","volume":"79","author":"Chong","year":"2024","journal-title":"Med. J. Malays."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1089\/ther.2020.0035","article-title":"Organ Complications of Infants with Hypoxic Ischemic Encephalopathy Before Therapeutic Hypothermia","volume":"11","author":"Michniewicz","year":"2021","journal-title":"Ther. Hypothermia Temp. Manag."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PCC.0000000000001068","article-title":"The Severity of Hypoxic-Ischemic Encephalopathy Correlates With Multiple Organ Dysfunction in the Hypothermia Era","volume":"18","author":"Alsina","year":"2017","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/apa.16111","article-title":"Multi-organ dysfunction scoring in neonatal encephalopathy (MODE Score) and neurodevelopmental outcomes","volume":"111","author":"Sweetman","year":"2022","journal-title":"Acta Paediatr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Toptan, H.H., Tezel, K.G., Tezel, O., Ata\u00e7, \u00d6., Vardar, G., G\u00fclcan Kersin, S., and \u00d6zek, E. (2024). Inflammatory and Hematologic Liver and Platelet (HALP) Scores in Hypothermia-Treated Hypoxic-Ischemic Encephalopathy (HIE). Children, 11.","DOI":"10.3390\/children11010072"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Committee on Fetus and Newborn (2014). Hypothermia and neonatal encephalopathy. Pediatrics, 133, 1146\u20131150.","DOI":"10.1542\/peds.2014-0899"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. a clinical and electroencephalographicstudy","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch. Neurol."},{"key":"ref_19","first-page":"329","article-title":"The effects of Vasoactive-Ventilation-Renal score on pediatric heart surgery","volume":"7","author":"Ozturk","year":"2020","journal-title":"North. Clin. Istanb."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/ehf2.13829","article-title":"Prognostic value of the liver fibrosis marker fibrosis-5 index in patients with acute heart failure","volume":"9","author":"Maeda","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/adc.2011.214205","article-title":"Cardiovascular dysfunction in infants with neonatal encephalopathy","volume":"97","author":"Armstrong","year":"2012","journal-title":"Arch. Dis. Child."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.siny.2014.10.005","article-title":"Physiological responses to hypothermia","volume":"20","author":"Wood","year":"2015","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1542\/peds.2004-1587","article-title":"Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarming","volume":"117","author":"Gebauer","year":"2006","journal-title":"Pediatrics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/adc.2002.023093","article-title":"Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy","volume":"89","author":"Shah","year":"2004","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0022-3476(95)70174-5","article-title":"Multiple organ involvement in perinatal asphyxia","volume":"127","author":"Gaya","year":"1995","journal-title":"J. Pediatr."},{"key":"ref_26","first-page":"688","article-title":"Neonatal organ system injury in acute birth asphyxia sufficient to result in neonatal encephalopathy","volume":"99","author":"Hankins","year":"2002","journal-title":"Obs. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41372-019-0349-2","article-title":"Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy","volume":"39","author":"Szakmar","year":"2019","journal-title":"J. Perinatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/PCC.0000000000000153","article-title":"Vasoactive-inotropic score is associated with outcome after infant cardiac surgery: An analysis from the Pediatric Cardiac Critical Care Consortium and Virtual PICU System Registries","volume":"15","author":"Gaies","year":"2014","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/icvts\/ivu409","article-title":"Use of a novel vasoactive-ventilation-renal score to predict outcomes after paediatric cardiac surgery","volume":"20","author":"Miletic","year":"2015","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4103\/IJCIIS.IJCIIS_1_18","article-title":"Vasoactive-ventilation-renal score in predicting outcome postcardiac surgery in children","volume":"8","author":"Alam","year":"2018","journal-title":"Int. J. Crit. Illn. Inj. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.athoracsur.2015.11.006","article-title":"Prospective Validation of a Novel Vasoactive-Ventilation-Renal Score as a Predictor of Outcomes After Pediatric Cardiac Surgery","volume":"101","author":"Miletic","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jtcvs.2016.07.070","article-title":"Vasoactive-ventilation-renal score reliably predicts hospital length of stay after surgery for congenital heart disease","volume":"152","author":"Scherer","year":"2016","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/PCC.0000000000001694","article-title":"Multicenter Validation of the Vasoactive-Ventilation-Renal Score as a Predictor of Prolonged Mechanical Ventilation After Neonatal Cardiac Surgery","volume":"19","author":"Cashen","year":"2018","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jpeds.2018.04.076","article-title":"Renal Saturation and Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia","volume":"200","author":"Chock","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00467-008-1060-2","article-title":"Acute kidney injury in critically ill newborns: What do we know? What do we need to learn?","volume":"24","author":"Askenazi","year":"2009","journal-title":"Pediatr. Nephrol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jpeds.2012.10.002","article-title":"Acute kidney injury in asphyxiated newborns treated with therapeutic hypothermia","volume":"162","author":"Selewski","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/pr.2013.230","article-title":"Relationship between acute kidney injury and brain MRI findings in asphyxiated newborns after therapeutic hypothermia","volume":"75","author":"Sarkar","year":"2014","journal-title":"Pediatr. Res."},{"key":"ref_38","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group (2009). KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney DiseaseMineral and Bone Disorder (CKD-MBD). Kidney Int. Suppl., 76, 1\u2013130."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.earlhumdev.2016.12.006","article-title":"Neonatal acute kidney injury-Severity and recovery prediction and the role of serum and urinary biomarkers","volume":"105","author":"Sweetman","year":"2017","journal-title":"Early Hum. Dev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/CMPed.S21426","article-title":"Hepatic dysfunction in asphyxiated neonates: Prospective case-controlled study","volume":"9","author":"Choudhary","year":"2015","journal-title":"Clin. Med. Insights Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00431-017-2956-2","article-title":"Biomarkers of hepatic injury and function in neonatal hypoxic ischemic encephalopathy and with therapeutic hypothermia","volume":"176","author":"Muniraman","year":"2017","journal-title":"Eur. J. Pediatr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/hep.28016","article-title":"Aspartate aminotransferase to platelet ratio and fibrosis-4 as biomarkers in biopsy-validated pediatric cystic fibrosis liver disease","volume":"62","author":"Leung","year":"2015","journal-title":"Hepatology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00383-023-05373-6","article-title":"Development and validation of non-invasive models in predicting advanced fibrosis of choledochal cyst","volume":"39","author":"Chen","year":"2023","journal-title":"Pediatr. Surg. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.gastha.2022.09.005","article-title":"Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects","volume":"2","author":"Okamoto","year":"2022","journal-title":"Gastro Hep Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"107537","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107537","article-title":"Liver fibrosis index is associated with functional outcome among acute ischemic stroke patients","volume":"33","author":"Eto","year":"2024","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, Z., Li, G., Huang, R., Chang, L., Gong, C., Chen, K., and Wang, L. (2023). Prognostic value of fibrosis-5 index combined with C-reactive protein in patients with acute decompensated heart failure. BMC Cardiovasc. Disord., 23.","DOI":"10.1186\/s12872-023-03530-2"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.ajem.2020.06.067","article-title":"Lactate\/albumin ratio: An early prognostic marker in critically ill patients","volume":"38","author":"Gharipour","year":"2020","journal-title":"Am. J. Emerg. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"118","DOI":"10.21037\/atm-20-4519","article-title":"The value of lactate\/albumin ratio for predicting the clinical outcomes of critically ill patients with heart failure","volume":"9","author":"Guo","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_49","first-page":"e36816","article-title":"Serum lactate-albumin ratio: Soothsayer for outcome in sepsis","volume":"15","author":"Kabra","year":"2023","journal-title":"Cureus"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Nishioka, N., Kobayashi, D., Izawa, J., Irisawa, T., Yamada, T., Yoshiya, K., Park, C., Nishimura, T., Ishibe, T., and Yagi, Y. (2021). Association between serum lactate level during cardiopulmonary resuscitation and survival in adult out-of-hospital cardiac arrest: A multicenter cohort study. Sci. Rep., 11.","DOI":"10.21203\/rs.3.rs-40098\/v1"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2350238","DOI":"10.1080\/0886022X.2024.2350238","article-title":"Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury","volume":"46","author":"Shi","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wang, R., He, M., Qu, F., Zhang, J., and Xu, J. (2022). Lactate albumin ratio is associated with mortality in patients with moderate to severe traumatic brain injury. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.662385"},{"key":"ref_53","first-page":"11","article-title":"Assessing the prognostic value of crp\/albumin ratio and lactate\/albumin ratio in critically ill patients","volume":"70","author":"Sai","year":"2022","journal-title":"J. Assoc. Physicians India."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"10511","DOI":"10.2147\/IJGM.S339767","article-title":"The lactate\/albumin ratio predicts mortality in critically ill patients with acute kidney injury: An observational multicenter study on the eICU database","volume":"14","author":"Zhu","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2217\/fmb-2023-0125","article-title":"Importance of lactate\/albumin ratio in pediatric nosocomial infection and mortality at different times","volume":"19","author":"Keskin","year":"2024","journal-title":"Future Microbiol."},{"key":"ref_56","first-page":"493","article-title":"The Lactate\/Albumin Ratio is an Effective Predictor for Mortality in Critically Ill Children","volume":"14","author":"Durak","year":"2020","journal-title":"T\u00fcrkiye \u00c7ocuk Hast. Derg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00431-012-1890-6","article-title":"Biomarkers of acute kidney injury in neonatal encephalopathy","volume":"172","author":"Sweetman","year":"2013","journal-title":"Eur. J. Pediatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/apa.13555","article-title":"Renal function and novel urinary biomarkers in infants with neonatal encephalopathy","volume":"105","author":"Sweetman","year":"2016","journal-title":"Acta Paediatr."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/24\/2796\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:53:41Z","timestamp":1760115221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/24\/2796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":58,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["diagnostics14242796"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14242796","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]}}}