{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:17Z","timestamp":1760146817558,"version":"build-2065373602"},"reference-count":6,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Medical University of Bia\u0142ystok","doi-asserted-by":"publisher","award":["B.SUB.23.600","B.SUB.24.181","B.SUB.24.535"],"award-info":[{"award-number":["B.SUB.23.600","B.SUB.24.181","B.SUB.24.535"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cardiac transthyretin amyloidosis is an underdiagnosed disorder with significant diagnostic difficulties due to its non-specific clinical manifestations. It is caused by the deposition of protein aggregates with an abnormal tertiary structure in the extracellular matrix. Their accumulation leads to the development of hypertrophic and restrictive cardiomyopathy and, at a later stage, heart failure with preserved ejection fraction syndrome. Depending on the pathogenesis, there are different types of the disease\u2014hereditary and age-related wild-type transthyretin amyloidosis. We present the case of an 85-year-old woman who was referred to the department with a two-month history of exertional dyspnea in New York Heart Association functional class II. After reviewing the initial findings, several red flags for cardiac amyloidosis (CA) were identified. Following the diagnostic algorithm, scintigraphy was performed and showed significant radioisotope accumulation in the myocardium, confirming the suspected disease. In this manuscript, we present the current recommendations and diagnostic pathway, discussing in detail both available and emerging treatment options. As early diagnosis is essential to prevent the development of serious complications, we would like to highlight the pitfalls in diagnosing CA and emphasize the need to be aware of its variable clinical presentation and red flags.<\/jats:p>","DOI":"10.3390\/diagnostics14242812","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T09:17:58Z","timestamp":1734340678000},"page":"2812","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Red Flags of Cardiac Amyloidosis in a Single Patient: Clinical Manifestations of an Underdiagnosed Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-1913","authenticated-orcid":false,"given":"Emil Julian","family":"D\u0105browski","sequence":"first","affiliation":[{"name":"Department of Invasive Cardiology, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiktoria Urszula","family":"Koz\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja Oliwia","family":"Lipska","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Matys","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szymon","family":"Pogorzelski","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1430-7455","authenticated-orcid":false,"given":"Marcin","family":"Ko\u017cuch","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Dobrzycki","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Medical University of Bia\u0142ystok, 15-089 Bia\u0142ystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/eurheartj\/ehab072","article-title":"Diagnosis and treatment of cardiac amyloidosis: A position statement of the ESC Working Group on Myocardial and Pericardial Diseases","volume":"42","author":"Rapezzi","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_2","first-page":"129","article-title":"Stanowisko ekspert\u00f3w Polskiego Towarzystwa Kardiologicznego dotycz\u0105ce diagnostyki i leczenia amyloidozy transtyretynowej serca","volume":"81","author":"Grzybowski","year":"2023","journal-title":"Pol. Heart J. (Kardiol. Pol.)"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5334\/gh.1262","article-title":"World Heart Federation Consensus on Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)","volume":"18","author":"Brito","year":"2023","journal-title":"Glob. Heart"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Healy, L., Giblin, G., Gray, A., Starr, N., Murphy, L., O\u2019Sullivan, D., Kavanagh, E., Howley, C., Tracey, C., and Morrin, E. (2024). Prevalence of transthyretin cardiac amyloidosis in undifferentiated heart failure with preserved ejection fraction. ESC Heart Fail., ahead of print.","DOI":"10.1002\/ehf2.15112"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1002\/ehf2.14971","article-title":"Prevalence and characteristics of transthyretin amyloid cardiomyopathy in hypertrophic cardiomyopathy","volume":"11","author":"Damy","year":"2024","journal-title":"ESC Heart Fail"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Fontana, M., Berk, J.L., Gillmore, J.D., Witteles, R.M., Grogan, M., Drachman, B., Damy, T., Garcia-Pavia, P., Taubel, J., and Solomon, S.D. (2024). Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy. New Engl. J. Med., ahead of print.","DOI":"10.1056\/NEJMoa2409134"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/24\/2812\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:00Z","timestamp":1760115300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/24\/2812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,13]]},"references-count":6,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["diagnostics14242812"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14242812","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2024,12,13]]}}}