{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:33:21Z","timestamp":1773480801467,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Recent studies indicate that sleep and sleep disorders differ between men and women, but corresponding data in people with chronic lung diseases are lacking. This study aims to answer the question of what the sex-specific differences in sleep profiles and responses to elexacaftor\/tezacaftor\/ivacaftor (ETI) therapy in people with cystic fibrosis (pwCF) are. Methods: Adult pwCF and a matched control group (adults with suspected sleep-disordered breathing undergoing in-laboratory polysomnography (PSG)) were included. PSG data at baseline and after 6 months\u2019 ETI therapy were compared between men (mwCF) and women (wwCF) with cystic fibrosis. PSG data at baseline and 6-month follow-up for mwCF\/wwCF were compared with baseline PSG data for men\/women in the control group. Daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS). Correlations between change in percentage predicted forced expiratory volume in 1 s from baseline to 6 months were correlated with corresponding changes in key sleep parameters. Changes in transferrin during ETI therapy were also documented. Results: Twenty-eight pwCF (12 wwCF, 16 mwCF) and 28 matched controls were included. Both mwCF (4 \u00b1 5 vs. 9 \u00b1 20 events\/h, p = 0.028) and wwCF (3 \u00b1 3 vs. 8 \u00b1 9 events\/h, p = 0.004) had fewer respiratory events during sleep versus male and female controls, but worse sleep efficiency (75 \u00b1 11% vs. 84 \u00b1 11%; p = 0.004 and 76 \u00b1 10% vs. 83 \u00b1 11%; p = 0.011. The baseline ESS score was significantly higher in wwCF versus female controls (8 \u00b1 4 vs. 14 \u00b1 8; p = 0.040). Although some sleep parameters normalized during ETI therapy in pwCF, sleep quality remained poor. The transferrin levels at baseline (2.7 \u00b1 0.4 vs. 2.2 \u00b1 0.5; p = 0.049) and 6 months (3.8 \u00b1 0.4 vs. 2.6 \u00b1 0.5; p &lt; 0.001) were significantly higher in the wwCF versus the mwCF, and the change from baseline during ETI therapy was significantly greater in women versus men (1.1 \u00b1 0.6 vs. 0.4 \u00b1 0.4; p &lt; 0.001). Conclusions: These data suggest that wwCF and mwCF should be managed differently with respect to their sleep.<\/jats:p>","DOI":"10.3390\/diagnostics14242859","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T10:54:20Z","timestamp":1734605660000},"page":"2859","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex Differences in Sleep Profiles and the Effect of Elexacaftor\/Tezacaftor\/Ivacaftor on Sleep Quality in Adult People with Cystic Fibrosis: A Prospective Observational Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-6670","authenticated-orcid":false,"given":"Sarah","family":"Dietz-Terjung","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, University Hospital Essen\u2014Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Tueschener Weg 40, 45329 Essen, Germany"},{"name":"Department of Sleep and Telemedicine, University Hospital Essen\u2014Ruhrlandklinik, University of Duisburg-Essen, 45239 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svenja","family":"Stra\u00dfburg","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, University Hospital Essen\u2014Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Tueschener Weg 40, 45329 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Schulte","sequence":"additional","affiliation":[{"name":"Department of Sleep and Telemedicine, University Hospital Essen\u2014Ruhrlandklinik, University of Duisburg-Essen, 45239 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Dietz","sequence":"additional","affiliation":[{"name":"Department of Sleep and Telemedicine, University Hospital Essen\u2014Ruhrlandklinik, University of Duisburg-Essen, 45239 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Weinreich","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, University Hospital Essen\u2014Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Tueschener Weg 40, 45329 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Taube","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, University Hospital Essen\u2014Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Tueschener Weg 40, 45329 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Sch\u00f6bel","sequence":"additional","affiliation":[{"name":"Department of Sleep and Telemedicine, University Hospital Essen\u2014Ruhrlandklinik, University of Duisburg-Essen, 45239 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-8911","authenticated-orcid":false,"given":"Matthias","family":"Welsner","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, University Hospital Essen\u2014Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Tueschener Weg 40, 45329 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivagurunathan","family":"Sutharsan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, University Hospital Essen\u2014Ruhrlandklinik, Adult Cystic Fibrosis Center, University of Duisburg-Essen, Tueschener Weg 40, 45329 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","unstructured":"Patel, A.K., Reddy, V., Shumway, K.R., and Araujo, J.F. 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Fibros."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/24\/2859\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:46Z","timestamp":1760115346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/14\/24\/2859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":34,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["diagnostics14242859"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics14242859","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]}}}