{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:04:57Z","timestamp":1790816697989,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Foggia","award":["PRA 2019"],"award-info":[{"award-number":["PRA 2019"]}]},{"name":"University of Foggia","award":["PRA 2021"],"award-info":[{"award-number":["PRA 2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Monoclonal gammopathy of renal significance (MGRS) refers to a group of renal disorders caused by a monoclonal immunoglobulin (MIg), secreted by a non-malignant B-cell clone. Unlike overt multiple myeloma or B-cell proliferation, MGRS does not meet those diagnostic criteria. However, it is associated with significant morbidity, due to severe renal, and sometimes systemic, lesions induced by the MIg. Early recognition is crucial, as chemotherapy to suppress MIg secretion often improves outcomes. The spectrum of renal diseases in MGRS is broad, including both well-known conditions like AL amyloidosis and newly described lesions. Kidney biopsy is essential to determine the specific lesion associated with MGRS and assess its severity. Diagnosis involves integrating morphologic alterations using techniques such as light microscopy, immunofluorescence (IF), electron microscopy, and, in some cases, IF staining for Ig isotypes, immunoelectron microscopy, and proteomic analysis. Additionally, a complete hematologic evaluation, including serum and urine protein electrophoresis, immunofixation, and a serum-free light-chain assay, is necessary.<\/jats:p>","DOI":"10.3390\/diagnostics14242892","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T09:13:38Z","timestamp":1734945218000},"page":"2892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic and Therapeutic Aspects of Monoclonal Gammopathies of Renal Significance (MGRS): An Update"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-2707","authenticated-orcid":false,"given":"Giuseppe Stefano","family":"Netti","sequence":"first","affiliation":[{"name":"Unit of Clinical Pathology, Department of Medical and Surgical Sciences, University of Foggia, University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"},{"name":"Center 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Rossini","sequence":"additional","affiliation":[{"name":"Unit of Nephrology, Dialysis and Transplantation, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari \u201cAldo Moro\u201d, Piazza Giulio Cesare 11, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8941-9312","authenticated-orcid":false,"given":"Valeria","family":"Catalano","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pathology, Department of Medical and Surgical Sciences, University of Foggia, University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, Italy"},{"name":"Center for Research and Innovation in Medicine (CREATE), Department of Medical and Surgical Sciences, University of Foggia, University Hospital \u201cPoliclinico Riuniti\u201d, Viale Luigi Pinto, 71122 Foggia, 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