{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:11:38Z","timestamp":1769040698417,"version":"3.49.0"},"reference-count":42,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["EXC 2145 SyNergy"],"award-info":[{"award-number":["EXC 2145 SyNergy"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["390857198"],"award-info":[{"award-number":["390857198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: 123Iodo-metaiodobenzylguanidine single photon emission computed tomography\/computed tomography (123I-MIBG SPECT\/CT) is used to evaluate the cardiac sympathetic nervous system in cardiac diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) and \u03b1-synucleinopathies such as Parkinson\u2019s diseases. A common feature of these diseases is denervation. We aimed to compare quantitative and semi-quantitative cardiac sympathetic innervation using 123I-MIBG imaging of ARVC and \u03b1-synucleinopathies. Methods: Cardiac innervation was assessed using 123I-MIBG SPECT\/CT in 20 patients diagnosed with definite ARVC and 8 patients with clinically diagnosed \u03b1-synucleinopathies. Heart-to-mediastinum-ratio (H\/M-ratio), as semi-quantitative, was evaluated. Additionally, standardized uptake value (SUV), as quantitative, was measured as SUVmedian, SUVmax, and SUVpeak in the left ventricle (LV), the right ventricle (RV), and in the global heart, based on a CT scan following quantitative image reconstruction. Results: The quantification of 123I-MIBG uptake in the LV, the RV, and the global heart was feasible in patients suffering from \u03b1-synucleinopathies. SUVmedian, and SUVpeak demonstrated a significant difference between ARVC and \u03b1-synucleinopathies across all regions, with the \u03b1-synucleinopathy group showing a lower uptake. In addition, the H\/M ratio showed significantly lower uptake in patients with \u03b1-synucleinopathies than in patients with ARVC. Conclusions: Patients with \u03b1-synucleinopathies demonstrate significantly lower cardiac innervation in semi-quantitative and quantitative examinations than ARVC patients. The comparison of semi-quantitative and quantitative examinations suggests that quantitative examination offers an advantage. Quantitative analysis can be performed separately for the LV, RV, and global heart. However, analyzing the LV or RV does not provide additional benefit over analyzing the global heart in distinguishing between \u03b1-synucleinopathies and ARVC. Considering the different clinical manifestations of these two diseases, the absolute SUV values should not be generalized across different pathologies, and disease-specific ranges should be used instead.<\/jats:p>","DOI":"10.3390\/diagnostics15010024","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T03:10:49Z","timestamp":1735182649000},"page":"24","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Efficacy of 123Iodo-Metaiodobenzylguanidine SPECT\/CT in Cardiac vs. Neurological Diseases: A Comparative Study of Arrhythmogenic Right Ventricular Cardiomyopathy and \u03b1-Synucleinopathies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2247-617X","authenticated-orcid":false,"given":"Johannes M.","family":"Hagen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Scheifele","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias J.","family":"Zacherl","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Katzdobler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians-University, 81377 Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians-University, 81377 Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"},{"name":"Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians-University, 81377 Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians-University, 81377 Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-6128","authenticated-orcid":false,"given":"Sebastian","family":"Clau\u00df","sequence":"additional","affiliation":[{"name":"Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, 81377 Munich, Germany"},{"name":"Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, 81377 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 81377 Munich, Germany"},{"name":"Institute of Surgical Research, Walter-Brendel-Center of Experimental Medicine, University Hospital, LMU Munich, 81377 Munich, Germany"},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"K\u00e4\u00e4b","sequence":"additional","affiliation":[{"name":"Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, 81377 Munich, Germany"},{"name":"Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, 81377 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 81377 Munich, Germany"},{"name":"Institute of Surgical Research, Walter-Brendel-Center of Experimental Medicine, University Hospital, LMU Munich, 81377 Munich, Germany"},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1504-6565","authenticated-orcid":false,"given":"Andrei","family":"Todica","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-2929","authenticated-orcid":false,"given":"Guido","family":"Boening","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ludwig-Maximilians-University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9172-3316","authenticated-orcid":false,"given":"Maximilian","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Medicine I, University Hospital Munich, Ludwig-Maximilians-University, 81377 Munich, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"JCS Joint Working Group (2012). 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