{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:41:12Z","timestamp":1760146872197,"version":"build-2065373602"},"reference-count":5,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>This report describes a rare occurrence of benign fibrous histiocytoma in the frontal sinus of a 38-year-old male. The patient presented with acute symptoms, including sudden-onset headache, nausea, and general discomfort, although neurological, otorhinolaryngological and laboratory examinations showed no abnormalities. A cranial CT scan revealed a cystic, osteodestructive lesion measuring 2.5 cm in the far lateral right frontal sinus, initially suspected to be a mucocele due to radiological characteristics and the patient\u2019s history of recurring frontal headaches and retrobulbar pressure. Elective surgical excision was performed via an external supraorbital approach due to the lesion\u2019s lateral location. Histopathological examination of the excised tissue revealed characteristic features of benign fibrous histiocytoma, including spindle cell proliferation and the presence of histiocytes and siderophages. Immunohistochemistry further supported the diagnosis, showing EMA, S100, and creatinine negativity with SMA positivity. This case is unique, as it represents the first reported benign fibrous histiocytoma in the frontal sinus. During regular follow-up, the patient remained symptom-free and showed no recurrence. This report underscores the importance of considering rare diagnoses for cystic skull lesions and supports tailored surgical approaches based on lesion location.<\/jats:p>","DOI":"10.3390\/diagnostics15010056","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T14:21:12Z","timestamp":1735654872000},"page":"56","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fibrous Histiocytoma in the Far Lateral Frontal Sinus\u2014A Rare Observation"],"prefix":"10.3390","volume":"15","author":[{"given":"Alexander","family":"Wilhelmer","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Medical University of Graz, Auenbruggerplatz 26, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9187-2063","authenticated-orcid":false,"given":"Peter","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Medical University of Graz, Auenbruggerplatz 26, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Habenbacher","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Medical University of Graz, Auenbruggerplatz 26, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-8416","authenticated-orcid":false,"given":"Luka","family":"Br\u010di\u0107","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Institute of Pathology, Medical University of Graz, Auenbruggerplatz 26, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2530-9931","authenticated-orcid":false,"given":"Alexandros","family":"Andrianakis","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Medical University of Graz, Auenbruggerplatz 26, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"ref_1","first-page":"149","article-title":"Cutaneous mesenchymal tumors: An update","volume":"46","author":"Thomas","year":"2014","journal-title":"Pathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12957-015-0587-5","article-title":"Benign fibrous histiocytoma of parietal bone: Case report and review of the literature","volume":"13","author":"Yang","year":"2015","journal-title":"World J. Surg. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1288\/00005537-198012000-00013","article-title":"Malignant fibrous histiocytoma of the frontal sinus","volume":"90","author":"Schaefer","year":"1980","journal-title":"Laryngoscope"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/archotol.1973.00780020055013","article-title":"Fibrous Histiocytoma of the Paranasal Sinuses","volume":"98","author":"Townsend","year":"1973","journal-title":"Arch. Otolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0194-59989570159-1","article-title":"Noncutaneous benign fibrous histiocytoma of the head and neck","volume":"113","author":"Bielamowicz","year":"1995","journal-title":"Otolaryngol. Head Neck Surg."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/1\/56\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:40Z","timestamp":1760115340000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/1\/56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["diagnostics15010056"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15010056","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2024,12,28]]}}}