{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:10:16Z","timestamp":1790604616240,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babes University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Acute pancreatitis is a common condition with a variable prognosis. While the overall mortality rate of acute pancreatitis is relatively low, ranging between 3 and 5% in most cases, severe forms can result in significantly higher morbidity and mortality. Therefore, early risk assessment is crucial for optimizing management and treatment. The aim of the present study wasto compare simple prognostic markers and identify the best predictors of severity in patients with acute pancreatitis. Material and Methods: A retrospective analysis was carried outon 108 patients admitted in our center during one year with acute biliary pancreatitis. Acute pancreatitis severity was stratified based on the revised Atlanta criteria. Results: 108 subjects (mean age of 60.1 \u00b1 18.6, 65.7% females) diagnosed with acute biliary pancreatitis were included. Based on the Atlanta criteria, 59.3% (64\/108) of the subjects were classified as having mild acute biliary pancreatitis, 35.2% (38\/108) as having a moderate\u2013severe pancreatitis, and 5.5% (6\/108) were classified as having severe acute pancreatitis. In univariate analysis, the following parameterswere associatedwith at least a moderate\u2013severe form of acute pancreatitis: Balthazar score, fasting blood glucose (mg\/dL), modified CTSI score, CRP values at 48 h, BISAP score at admission, CTSI score, Ranson score, duration of hospitalization (days), and the presence of leukocytosis (\u00d71000\/\u00b5L) (all p &lt; 0.05).BISAP score at admission (AUC-0.91), CRP levels at 48 h (AUC-0.92), mCTSI (AUC-0.94), and CTSI score (AUC-0.93) had the highest area under the curve (AUC) for predicting the severity of acute pancreatitis. In multivariate analysis, the model including the following independent parameters was predictive for the severity of acute pancreatitis: CTSI score (p &lt; 0.0001), BISAP score (p = 0.0082), and CRP levels at 48 h (p = 0.0091), respectively. The model showed a slightly higher AUC compared to the independent predictors (AUC-0.96). Conclusions: The use of a multiparametric prediction model can increase the accuracy of predicting severity in patients with acute biliary pancreatitis.<\/jats:p>","DOI":"10.3390\/diagnostics15020126","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T07:42:19Z","timestamp":1736235739000},"page":"126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prediction Models of Severity in Acute Biliary Pancreatitis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-9926","authenticated-orcid":false,"given":"Iulia","family":"Ratiu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Bende","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia","family":"Nica","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Budii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-4546","authenticated-orcid":false,"given":"Calin","family":"Burciu","sequence":"additional","affiliation":[{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Department of Gastroenterology, Faculty of Medicine, Pharmacy and Dental Medicine, \u201cVasile Goldis\u201d West University of Arad, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Barbulescu","sequence":"additional","affiliation":[{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8978-1856","authenticated-orcid":false,"given":"Tudor","family":"Moga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-5789","authenticated-orcid":false,"given":"Bogdan","family":"Miutescu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Sirli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela","family":"Danila","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-7325","authenticated-orcid":false,"given":"Felix","family":"Bende","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Advanced Regional Research Center in Gastroenterology and Hepatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","article-title":"Acute pancreatitis","volume":"386","author":"Lankisch","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1111\/j.1572-0241.2006.00856.x","article-title":"Practice guidelines in acute pancreatitis","volume":"101","author":"Banks","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e28121","DOI":"10.1097\/MD.0000000000028121","article-title":"The BISAP score, NLR, CRP, or BUN: Which marker best predicts the outcome of acute pancreatitis?","volume":"100","author":"Dancu","year":"2021","journal-title":"Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrgastro.2010.114","article-title":"Etiology and diagnosis of acute biliary pancreatitis","volume":"7","author":"Bhagirath","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(89)90381-4","article-title":"APACHE-II score for assessment and monitoring of acute pancreatitis","volume":"2","author":"Larvin","year":"1989","journal-title":"Lancet"},{"key":"ref_6","first-page":"69","article-title":"Prognostic signs and the role of operative management in acute pancreatitis","volume":"139","author":"Ranson","year":"1974","journal-title":"Surg. Gynecol. Obstet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.3748\/wjg.v21.i8.2387","article-title":"Comparison of scoring systems in predicting the severity of acute pancreatitis","volume":"21","author":"Cho","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis\u20142012: Revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/17474124.2021.1924058","article-title":"Ranson score to stratify severity in acute pancreatitis remains valid\u2014Old is gold","volume":"15","author":"Ong","year":"2021","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3904\/kjim.2013.28.3.322","article-title":"A comparison of the BISAP score and serum procalcitonin for predicting the severity of acute pancreatitis","volume":"28","author":"Kim","year":"2013","journal-title":"Korean J. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000441003","article-title":"Evaluating the ability of the Bedside Index for Severity of Acute Pancreatitis score to predict severe acute pancreatitis: A meta-analysis","volume":"25","author":"Yang","year":"2016","journal-title":"Med. Princ. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3389\/fphys.2019.01002","article-title":"Computed Tomography Severity Index vs. other indices in the prediction of severity and mortality in acute pancreatitis: A predictive accuracy meta-analysis","volume":"10","author":"Vigh","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.5152\/tjg.2022.22098","article-title":"The diagnostic value of procalcitonin in patients with severe acute pancreatitis: A meta-analysis","volume":"33","author":"Chen","year":"2022","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1046\/j.1365-2168.2001.01673.x","article-title":"Procalcitonin strip test in the early detection of severe acute pancreatitis","volume":"88","author":"Takala","year":"2001","journal-title":"Br. J. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41419-017-0135-z","article-title":"Cellular death, reactive oxygen species (ROS) and diabetic complications","volume":"9","author":"Volpe","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/cts.13445","article-title":"Relationship between blood glucose levels and length of hospital stay in patients with acute pancreatitis: An analysis of MIMIC-III database","volume":"16","author":"Wang","year":"2023","journal-title":"Clin. Transl. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lu, Y., Zhang, Q., and Lou, J. (2021). Blood glucose-related indicators are associated with in-hospital mortality in critically ill patients with acute pancreatitis. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-94697-1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.2147\/IJGM.S384068","article-title":"Combination of the BISAP score and miR-155 is applied in predicting the severity of acute pancreatitis","volume":"15","author":"Wu","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijsu.2018.04.026","article-title":"Evaluation of the BISAP scoring system in prognostication of acute pancreatitis: A prospective observational study","volume":"54","author":"Hagjer","year":"2018","journal-title":"Int. J. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e35934","DOI":"10.1097\/MD.0000000000035934","article-title":"Clinical value of BISAP score combined with CRP and NLR in evaluating the severity of acute pancreatitis","volume":"102","author":"Lu","year":"2023","journal-title":"Medicine"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/2\/126\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:24:27Z","timestamp":1759919067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/2\/126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["diagnostics15020126"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15020126","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}