{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:04:49Z","timestamp":1792829089860,"version":"4.5.0"},"reference-count":93,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Marfan syndrome (MFS) is a genetic disorder affecting connective tissue, often leading to cardiovascular complications such as aortic aneurysms and mitral valve prolapse. Cardiovascular multimodality imaging plays a crucial role in the diagnosis, monitoring, and management of MFS patients. This review explores the advancements in echocardiography, cardiovascular magnetic resonance (CMR), cardiac computed tomography (CCT), and nuclear medicine techniques in MFS. Echocardiography remains the first-line tool, essential for assessing aortic root, mitral valve abnormalities, and cardiac function. CMR provides detailed anatomical and functional assessments without radiation exposure, making it ideal for long-term follow-up. CT offers high-resolution imaging of the aorta, crucial for surgical planning, despite its ionizing radiation. Emerging nuclear medicine techniques, though less common, show promise in evaluating myocardial involvement and inflammatory conditions. This review underscores the importance of a comprehensive imaging approach to improve outcomes and guide interventions in MFS patients. It also introduces novel aspects of multimodality approaches, emphasizing their impact on early detection and management of cardiovascular complications in MFS.<\/jats:p>","DOI":"10.3390\/diagnostics15020172","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T03:29:43Z","timestamp":1736825383000},"page":"172","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Advances in Cardiovascular Multimodality Imaging in Patients with Marfan Syndrome"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-2621","authenticated-orcid":false,"given":"Marco Alfonso","family":"Perrone","sequence":"first","affiliation":[{"name":"Division of Cardiology and CardioLab, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy"},{"name":"Clinical Pathways and Epidemiology Unit, Bambino Ges\u00f9 Children\u2019s Hospital IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Moscatelli","sequence":"additional","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK"},{"name":"Institute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK"},{"name":"Paediatric Cardiology Unit, Royal Brompton Hospital, London SW36NP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Guglielmi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-3402","authenticated-orcid":false,"given":"Francesco","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, AOU Ospedali Riuniti, 60126 Ancona, 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-2457","authenticated-orcid":false,"given":"Enrico Emilio","family":"Diviggiano","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-6337","authenticated-orcid":false,"given":"Maria","family":"Ricci","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Cardarelli Hospital, 86100 Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8374-0260","authenticated-orcid":false,"given":"Pier Paolo","family":"Bassareo","sequence":"additional","affiliation":[{"name":"School of Medicine, University College of Dublin, Mater Misericordiae University Hospital, D07 R2WY Dublin, 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Med. Genet."},{"key":"ref_2","first-page":"ZJ01","article-title":"Ghent Criteria an Aid to Diagnose Latent Systemic Diseases in Marfan Syndrome","volume":"9","author":"Ramlingam","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1093\/eurheartj\/ehae179","article-title":"2024 ESC Guidelines for the management of peripheral arterial and aortic diseases","volume":"45","author":"Mazzolai","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmu.2011.03.001","article-title":"Marfan Syndrome-An Echocardiographer\u2019s Perspective","volume":"19","author":"Yu","year":"2011","journal-title":"J. Med. Ultrasound"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-030-80614-9_8","article-title":"Pathophysiology and Pathogenesis of Marfan Syndrome","volume":"1348","author":"Zeigler","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.echo.2013.02.018","article-title":"Echocardiographic methods, quality review, and measurement accuracy in a randomized multicenter clinical trial of Marfan syndrome","volume":"26","author":"Levine","year":"2013","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Moscatelli, S., Pergola, V., Motta, R., Fortuni, F., Borrelli, N., Sabatino, J., Leo, I., Avesani, M., Montanaro, C., and Surkova, E. (2023). Multimodality Imaging Assessment of Tetralogy of Fallot: From Diagnosis to Long-Term Follow-Up. Children, 10.","DOI":"10.3390\/children10111747"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.cjca.2021.03.002","article-title":"Coronary Artery Aneurysms in Patients With Marfan Syndrome: Frequent, Progressive, and Relevant","volume":"37","author":"Mariucci","year":"2021","journal-title":"Can. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Colan, S.D. (2016). Normal Echocardiographic Values for Cardiovascular Structures. Echocardiography in Pediatric and Congenital Heart Disease, Wiley.","DOI":"10.1002\/9781118742440.app1"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/ehjci\/jeaa324","article-title":"Mitral annulus disjunction is associated with adverse outcome in Marfan and Loeys-Dietz syndromes","volume":"22","author":"Chivulescu","year":"2021","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0002-9149(89)90430-X","article-title":"Two-dimensional echocardiographic aortic root dimensions in normal children and adults","volume":"64","author":"Roman","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.116.009762","article-title":"Hereditary Influence in Thoracic Aortic Aneurysm and Dissection","volume":"133","author":"Isselbacher","year":"2016","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/CIRCULATIONAHA.111.054676","article-title":"Aortic event rate in the Marfan population: A cohort study","volume":"125","author":"Jondeau","year":"2012","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/eurheartj\/ehl457","article-title":"Relation of aortic root dilatation and age in Marfan\u2019s syndrome","volume":"28","author":"Aburawi","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1540-8175.2008.00825.x","article-title":"Mitral valve prolapse in Marfan syndrome: An old topic revisited","volume":"26","author":"Taub","year":"2009","journal-title":"Echocardiography"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1161\/CIRCULATIONAHA.112.000113","article-title":"Mitral valve disease in patients with Marfan syndrome undergoing aortic root replacement","volume":"128","author":"Kunkala","year":"2013","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(05)17869-6","article-title":"Mitral valve prolapse","volume":"365","author":"Hayek","year":"2005","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/ehjci\/jead332","article-title":"Arrhythmic mitral valve prolapse: A practical approach for asymptomatic patients","volume":"25","author":"Malagoli","year":"2024","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1093\/eurheartj\/ehq258","article-title":"Cardiovascular manifestations in men and women carrying a FBN1 mutation","volume":"31","author":"Faivre","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1001\/jamacardio.2021.2312","article-title":"Association of Mitral Annular Disjunction With Cardiovascular Outcomes Among Patients With Marfan Syndrome","volume":"6","author":"Demolder","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Perazzolo Marra, M., Basso, C., De Lazzari, M., Rizzo, S., Cipriani, A., Giorgi, B., Lacognata, C., Rigato, I., Migliore, F., and Pilichou, K. (2016). Morphofunctional Abnormalities of Mitral Annulus and Arrhythmic Mitral Valve Prolapse. Circ. Cardiovasc. Imaging, 9.","DOI":"10.1161\/CIRCIMAGING.116.005030"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1476-7120-8-53","article-title":"Mitral annular disjunction in myxomatous mitral valve disease: A relevant abnormality recognizable by transthoracic echocardiography","volume":"8","author":"Carmo","year":"2010","journal-title":"Cardiovasc. Ultrasound"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.jcmg.2016.11.022","article-title":"Functional Implication of Mitral Annular Disjunction in Mitral Valve Prolapse: A Quantitative Dynamic 3D Echocardiographic Study","volume":"10","author":"Lee","year":"2017","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijcard.2004.08.014","article-title":"What is new in the Marfan syndrome?","volume":"97","author":"Nollen","year":"2004","journal-title":"Int. J. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/heart.87.5.470","article-title":"Pulmonary artery root dilatation in Marfan syndrome: Quantitative assessment of an unknown criterion","volume":"87","author":"Nollen","year":"2002","journal-title":"Heart"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/01.gim.0000223550.41849.e3","article-title":"A critical analysis of minor cardiovascular criteria in the diagnostic evaluation of patients with Marfan syndrome","volume":"8","author":"Loeys","year":"2006","journal-title":"Genet. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/ejcts\/ezv073","article-title":"Cardiomyopathy in Marfan syndrome","volume":"49","author":"Hetzer","year":"2016","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.amjcard.2004.11.042","article-title":"Evaluation of left ventricular dimensions and function in Marfan\u2019s syndrome without significant valvular regurgitation","volume":"95","author":"Meijboom","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0735-1097(02)02699-2","article-title":"Long-term outcome in patients with Marfan syndrome: Is aortic dissection the only cause of sudden death?","volume":"41","author":"Yetman","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/clc.3","article-title":"Tissue Doppler imaging identifies myocardial dysfunction in adults with Marfan syndrome","volume":"30","author":"Rybczynski","year":"2007","journal-title":"Clin. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00246-005-1139-5","article-title":"Left ventricular diastolic dysfunction in children and young adults with Marfan syndrome","volume":"27","author":"Das","year":"2006","journal-title":"Pediatr. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijcard.2005.10.010","article-title":"Primary impairment of left ventricular function in Marfan syndrome","volume":"112","author":"Devos","year":"2006","journal-title":"Int. J. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Demolder, A., von Kodolitsch, Y., Mui\u00f1o-Mosquera, L., and De Backer, J. (2020). Myocardial Function, Heart Failure and Arrhythmia in Marfan Syndrome: A Systematic Literature Review. Diagnostics, 10.","DOI":"10.3390\/diagnostics10100751"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2459\/JCM.0000000000001022","article-title":"The combined measurement of high-sensitivity cardiac troponins and natriuretic peptides: A useful tool for clinicians?","volume":"21","author":"Perrone","year":"2020","journal-title":"J. Cardiovasc. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/ejechocard\/jen003","article-title":"Early impairment of left ventricular long-axis systolic function demonstrated by reduced atrioventricular plane displacement in patients with Marfan syndrome","volume":"9","author":"Kiotsekoglou","year":"2008","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Abd El Rahman, M., Haase, D., Rentzsch, A., Olchvary, J., Sch\u00e4fers, H.J., Henn, W., Wagenpfeil, S., and Abdul-Khaliq, H. (2015). Left ventricular systolic dysfunction in asymptomatic Marfan syndrome patients is related to the severity of gene mutation: Insights from the novel three dimensional speckle tracking echocardiography. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124112"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1540-8175.2010.01359.x","article-title":"Impaired biventricular deformation in Marfan syndrome: A strain and strain rate study in adult unoperated patients","volume":"28","author":"Kiotsekoglou","year":"2011","journal-title":"Echocardiography"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.7863\/jum.2012.31.10.1609","article-title":"Early detection of cardiac dysfunction by strain and strain rate imaging in children and young adults with marfan syndrome","volume":"31","author":"Angtuaco","year":"2012","journal-title":"J. Ultrasound Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/RCT.0000000000000863","article-title":"Cardiovascular Magnetic Resonance Provides Evidence of Abnormal Myocardial Strain and Primary Cardiomyopathy in Marfan syndrome","volume":"43","author":"Winther","year":"2019","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/ejechocard\/jen239","article-title":"Impaired right ventricular systolic function demonstrated by reduced atrioventricular plane displacement in adults with Marfan syndrome","volume":"10","author":"Kiotsekoglou","year":"2009","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/ejechocard\/jep110","article-title":"Biventricular and atrial diastolic function assessment using conventional echocardiography and tissue-Doppler imaging in adults with Marfan syndrome","volume":"10","author":"Kiotsekoglou","year":"2009","journal-title":"Eur. J. Echocardiogr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1136\/heartjnl-2011-300169","article-title":"Intrinsic biventricular dysfunction in Marfan syndrome","volume":"97","author":"Aalberts","year":"2011","journal-title":"Heart"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/eurjhf\/hfq127","article-title":"Evidence for Marfan cardiomyopathy","volume":"12","author":"Alpendurada","year":"2010","journal-title":"Eur. J. Heart Fail."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/j.ijcard.2012.06.036","article-title":"Prospective risk stratification of sudden cardiac death in Marfan\u2019s syndrome","volume":"167","author":"Hoffmann","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Demolder, A., Bianco, L., Caruana, M., Cervi, E., Evangelista, A., Jondeau, G., Buttigieg, L.L., L\u00f3pez-Sainz, \u00c1., Delm\u00e1s, E.M., and Pini, A. (2022). Arrhythmia and impaired myocardial function in heritable thoracic aortic disease: An international retrospective cohort study. Eur. J. Med. Genet., 65.","DOI":"10.1016\/j.ejmg.2022.104503"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1001\/archinte.166.13.1350","article-title":"Diagnostic accuracy of transesophageal echocardiography, helical computed tomography, and magnetic resonance imaging for suspected thoracic aortic dissection","volume":"166","author":"Shiga","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00330-022-09162-y","article-title":"Assessment of aortic diameter in Marfan patients: Intraindividual comparison of 3D-Dixon and 2D-SSFP magnetic resonance imaging","volume":"33","author":"Wright","year":"2023","journal-title":"Eur. Radiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1093\/ehjci\/jead024","article-title":"Multimodality imaging in thoracic aortic diseases: A clinical consensus statement from the European Association of Cardiovascular Imaging and the European Society of Cardiology working group on aorta and peripheral vascular diseases","volume":"24","author":"Evangelista","year":"2023","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jcmg.2015.08.001","article-title":"Noninvasive Imaging of Flow and Vascular Function in Disease of the Aorta","volume":"8","author":"Whitlock","year":"2015","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.ijcard.2012.08.057","article-title":"MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome","volume":"167","author":"Scholte","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jcmg.2018.03.017","article-title":"Influence of Aortic Dilation on the Regional Aortic Stiffness of Bicuspid Aortic Valve Assessed by 4-Dimensional Flow Cardiac Magnetic Resonance: Comparison With Marfan Syndrome and Degenerative Aortic Aneurysm","volume":"12","author":"Guala","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1536\/ihj.26.1043","article-title":"Myocardial involvement in the Marfan syndrome","volume":"26","author":"Fujiseki","year":"1985","journal-title":"Jpn. Heart J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijcard.2019.06.016","article-title":"Serum free light chains in patients with ST elevation myocardial infarction (STEMI): A possible correlation with left ventricle dysfunction","volume":"292","author":"Perrone","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Moscatelli, S., Leo, I., Bianco, F., Borrelli, N., Beltrami, M., Garofalo, M., Milano, E.G., Bisaccia, G., Iellamo, F., and Bassareo, P.P. (2023). The Role of Multimodality Imaging in Pediatric Cardiomyopathies. J. Clin. Med., 12.","DOI":"10.3390\/jcm12144866"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Loeper, F., Oosterhof, J., Dorpel, M.v.D., van der Linde, D., Lu, Y., Robertson, E., Hambly, B., and Jeremy, R. (2016). Ventricular-Vascular Coupling in Marfan and Non-Marfan Aortopathies. J. Am. Heart Assoc., 5.","DOI":"10.1161\/JAHA.116.003705"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.amjcard.2022.04.012","article-title":"Prevalence and Outcomes of Primary Left Ventricular Dysfunction in Marfan Syndrome","volume":"175","author":"Connor","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s13023-020-01581-8","article-title":"Myocardial disease and ventricular arrhythmia in Marfan syndrome: A prospective study","volume":"15","author":"Devos","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1007\/s00330-020-07616-9","article-title":"Impact of chest wall deformity on cardiac function by CMR and feature-tracking strain analysis in paediatric patients with Marfan syndrome","volume":"31","author":"Groth","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ejrad.2011.01.071","article-title":"Accuracy of thoracic aortic measurements assessed by contrast enhanced and unenhanced magnetic resonance imaging","volume":"81","author":"Groth","year":"2012","journal-title":"Eur. J. Radiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2459\/JCM.0000000000000965","article-title":"Patient-specific three-dimensional aortic arch modeling for automatic measurements: Clinical validation in aortic coarctation","volume":"21","author":"Leonardi","year":"2020","journal-title":"J. Cardiovasc. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Leonardi, B., Gentili, F., Perrone, M.A., Sollazzo, F., Cocomello, L., Kikina, S.S., Wald, R.M., Palmieri, V., Secinaro, A., and Gagliardi, M.G. (2022). Cardiopulmonary Exercise Testing in Repaired Tetralogy of Fallot: Multiparametric Overview and Correlation with Cardiac Magnetic Resonance and Physical Activity Level. J. Cardiovasc. Dev. Dis., 9.","DOI":"10.3390\/jcdd9010026"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Aydin, A., Adsay, B.A., Sheikhzadeh, S., Keyser, B., Rybczynski, M., Sondermann, C., Detter, C., Steven, D., Robinson, P.N., and Berger, J. (2013). Observational cohort study of ventricular arrhythmia in adults with marfan syndrome caused by FBN1 mutations. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081281"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/europace\/euu310","article-title":"3D delayed-enhanced magnetic resonance sequences improve conducting channel delineation prior to ventricular tachycardia ablation","volume":"17","author":"Andreu","year":"2015","journal-title":"Europace"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Writing Committee Members, Isselbacher, E.M., Preventza, O., Hamilton Black, J., Augoustides, J.G., Beck, A.W., Bolen, M.A., Braverman, A.C., Bray, B.E., and Brown-Zimmerman, M.M. (2022). ACC\/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines. J. Am. Coll. Cardiol., 80, e223\u2013e393.","DOI":"10.1016\/j.jacc.2022.08.004"},{"key":"ref_67","first-page":"1698","article-title":"The role of 3D imaging in the follow-up of patients with repaired tetralogy of Fallot","volume":"23","author":"Leonardi","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_68","first-page":"58","article-title":"Clinical Features and Outcomes of Pregnancy-Related Acute Aortic Dissection","volume":"6","author":"Braverman","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Saremi, F. (2014). Cardiac CT and MR for Adult Congenital Heart Disease, Springer.","DOI":"10.1007\/978-1-4614-8875-0"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1148\/rg.220033","article-title":"Imaging of Genetic Thoracic Aortopathy","volume":"42","author":"Steinbrecher","year":"2022","journal-title":"RadioGraphics"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2459\/JCM.0000000000001628","article-title":"Recommendations for cardiovascular magnetic resonance and computed tomography in congenital heart disease: A consensus paper from the CMR\/CCT Working Group of the Italian Society of Pediatric Cardiology and the Italian College of Cardiac Radiology endorsed by the Italian Society of Medical and Interventional Radiology (Part II)","volume":"25","author":"Festa","year":"2024","journal-title":"J. Cardiovasc. Med."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Moscatelli, S., Bianco, F., Cimini, A., Panebianco, M., Leo, I., Bucciarelli-Ducci, C., and Perrone, M.A. (2023). The Use of Stress Cardiovascular Imaging in Pediatric Population. Children, 10.","DOI":"10.3390\/children10020218"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Beetz, N.L., Trippel, T.D., Philipp, K., Maier, C., Walter-Rittel, T., Shnayien, S., and Gehle, P. (2022). Discrepancy of echocardiography and computed tomography in initial assessment and 2-year follow-up for monitoring Marfan syndrome and related disorders. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-19662-y"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1097\/00006231-199308000-00013","article-title":"Marfan syndrome with myocarditis demonstrated by 99Tcm-HMPAO-labelled WBC and 201Tl scintig-raphy: Report of three cases in a Chinese family","volume":"14","author":"Yen","year":"1993","journal-title":"Nucl. Med. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Moscatelli, S., Leo, I., Bianco, F., Surkova, E., Pezel, T., Donald, N.A., Triumbari, E.K.A., Bassareo, P.P., Pradhan, A., and Cimini, A. (2023). The Role of Multimodality Imaging in Patients with Congenital Heart Disease and Infective Endocarditis. Diagnostics, 13.","DOI":"10.3390\/diagnostics13243638"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Singh, J., and Wanjari, A. (2022). Cardiac Complications in Marfan Syndrome: A Review. Cureus, 14.","DOI":"10.7759\/cureus.29800"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/ATVBAHA.114.304364","article-title":"Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of marfan syndrome","volume":"35","author":"Emrich","year":"2015","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2967\/jnumed.112.112524","article-title":"EANM\/SNMMI guideline for18F-FDG use in inflammation and infection","volume":"54","author":"Jamar","year":"2013","journal-title":"J. Nucl. Med."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Perrone, M.A., Cimini, A., Ricci, M., Pizzoferro, M., Garganese, M.C., Raponi, M., and Schillaci, O. (2023). Myocardial Functional Imaging in Pediatric Nuclear Cardiology. J. Cardiovasc. Dev. Dis., 10.","DOI":"10.3390\/jcdd10090361"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/S0735-1097(23)02461-0","article-title":"The use of 18-Fluorodeoxyglucose positron emission and computed tomography in the evaluation of Marfan syndrome patients","volume":"81","author":"Brili","year":"2023","journal-title":"JACC"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/rheumatology\/kew059","article-title":"Simultaneous presentation of IgG4-related chronic pe-ri-aortitis and coeliac disease in a patient with Marfan\u2019s Syndrome","volume":"55","author":"Lindsay","year":"2016","journal-title":"Rheumatology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/eurheartj\/ehl232","article-title":"Periaortitis complicating chronic aortic dissection","volume":"28","author":"Johnston","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11748-014-0516-5","article-title":"Surgical strategy for aortic prosthetic graft infection with (18)F-Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography","volume":"64","author":"Yamanaka","year":"2016","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5090\/kjtcs.2012.45.3.189","article-title":"Diagnosis of Graft Infection Using FDG PET-CT","volume":"45","author":"Shim","year":"2012","journal-title":"Korean J. Thorac. Cardiovasc. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s13256-020-02465-y","article-title":"Ascending aorta pseudoaneurysm simulating mediastinal lymphoma in computed tomography, a possible diagnostic error: A case report","volume":"14","author":"Chiocchi","year":"2020","journal-title":"J. Med. Case Rep."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Calabria, F.F., Guadagnino, G., Cimini, A., and Leporace, M. (2024). PET\/CT Imaging of Infectious Diseases: Overview of Novel Radi-opharmaceuticals. Diagnostics, 14.","DOI":"10.3390\/diagnostics14101043"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2459\/JCM.0000000000000668","article-title":"Primary cardiac lymphoma: The role of multimodality imaging","volume":"19","author":"Perrone","year":"2018","journal-title":"J. Cardiovasc. Med."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Cimini, A., Ricci, M., Chiaravalloti, A., Filippi, L., and Schillaci, O. (2020). Theragnostic Aspects and Radioimmunotherapy in Pediatric Tumors. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113849"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s12350-021-02526-9","article-title":"Incidental cardiac findings on somatostatin receptor PET\/CT: What do they indicate and are they of clinical relevance?","volume":"29","author":"Bobbio","year":"2022","journal-title":"J. Nucl. Cardiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/ijnm.ijnm_134_22","article-title":"Imaging Acute Myocarditis with 68Ga-DOTANOC PET\/CT","volume":"38","author":"Jaleel","year":"2023","journal-title":"Indian J. Nucl. Med."},{"key":"ref_91","unstructured":"(2024, November 24). Available online: https:\/\/www.clinicaltrials.gov\/study\/NCT04206163?cond=Myocardial%20Inflammation&term=PET%2FCT&rank=6."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"S333","DOI":"10.21037\/jtd.2017.04.18","article-title":"Role of molecular imaging with positron emission tomographic in aortic aneurysms","volume":"9","author":"Singh","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1017\/S1047951121001311","article-title":"Comparability of different Z-score equations for aortic root dimensions in children with Marfan syndrome","volume":"31","author":"Rutten","year":"2021","journal-title":"Cardiol. 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