{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:08:38Z","timestamp":1772449718221,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Recep Tayyip Erdogan University Development Foundation","award":["02024012009214"],"award-info":[{"award-number":["02024012009214"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The aim of our study was to evaluate the retinal nerve fiber layer (RNFL) and macular and choroidal thicknesses in women with different phenotypes of polycystic ovary syndrome (PCOS), and compare these measurements with those of healthy women of reproductive age. Materials and Methods: This prospective case\u2013control study included 120 eyes of 120 women with PCOS, with each of the four distinct phenotypes comprising 30 eyes of 30 women. Additionally, 30 eyes from 30 healthy women were included in the control group. All participants underwent comprehensive ophthalmologic examinations, and RNFL thickness, macular thickness (MT), and choroidal thickness (CT) in each eye were measured via spectral-domain optical coherence tomography. The body mass index (BMI) of the patients was recorded and compared with the retinal changes. Results: The average mean and nasal segments of the RNFL were significantly greater in the PCOS group than in the healthy control group (p &lt; 0.001). There was a statistically significant difference in foveal retinal thickness between the groups (p &lt; 0.001). Our study revealed significant choroidal tissue thickening subfoveally and at locations 500 \u03bcm temporal, 500 \u03bcm nasal, 1500 \u03bcm nasal, and 1500 \u03bcm temporal to the fovea in all phenotypes of the PCOS group (p &lt; 0.001). Additionally, there was a positive correlation between BMI and all CT changes. Conclusions: Our findings indicate that the retinal layers and choroid are affected by all phenotypes of PCOS, one of the most common reproductive abnormalities, albeit to varying degrees. Furthermore, these changes were found to be correlated with BMI.<\/jats:p>","DOI":"10.3390\/diagnostics15020227","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T04:04:12Z","timestamp":1737345852000},"page":"227","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-8190","authenticated-orcid":false,"given":"Fatma","family":"Sumer","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beril","family":"Gurlek","sequence":"additional","affiliation":[{"name":"Department of Obsetrics and Gynaecology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Obsetrics and Gynaecology, \u0130stanbul Gaziosmanpasa Training and Research Hospital, Istanbul 34255, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3050-0714","authenticated-orcid":false,"given":"Feyzahan","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabri","family":"Colak","sequence":"additional","affiliation":[{"name":"Department of Obsetrics and Gynaecology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilknur Merve","family":"Ayazoglu","sequence":"additional","affiliation":[{"name":"Department of Obsetrics and Gynaecology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CLEP.S37559","article-title":"Epidemiology, diagnosis, and management of polycystic ovary syndrome","volume":"6","author":"Sirmans","year":"2013","journal-title":"Clin. Epidemiol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sadeghi, H.M., Adeli, I., Calina, D., Docea, A.O., Mousavi, T., Daniali, M., Nikfar, S., Tsatsakis, A., and Abdollahi, M. (2022). Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020583"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100162","DOI":"10.1016\/j.endmts.2024.100162","article-title":"A review on critical appraisal and pathogenesis of polycystic ovarian syndrome","volume":"14","author":"Hajam","year":"2024","journal-title":"Endocr. Metab. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.coemr.2020.03.004","article-title":"Polycystic ovary syndrome phenotypes and prevalence: Differential impact of diagnostic criteria and clinical versus unselected population","volume":"12","author":"Mumusoglu","year":"2020","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.survophthal.2005.02.005","article-title":"Sex hormone receptors in the human eye","volume":"50","author":"Gupta","year":"2005","journal-title":"Surv. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Nuzzi, R., Scalabrin, S., Becco, A., and Panzica, G. (2018). Gonadal Hormones and Retinal Disorders: A Review. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00066"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nuzzi, R., Scalabrin, S., Becco, A., and Panzica, G. (2019). Sex Hormones and Optic Nerve Disorders: A Review. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.00057"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/IJG.0000000000001106","article-title":"Effects of Sex Hormones on Ocular Blood Flow and Intraocular Pressure in Primary Open-angle Glaucoma: A Review","volume":"27","author":"Patel","year":"2018","journal-title":"J. Glaucoma"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nuzzi, R., and Caselgrandi, P. (2022). Sex Hormones and Their Effects on Ocular Disorders and Pathophysiology: Current Aspects and Our Experience. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063269"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/jog.12673","article-title":"Ocular blood flow in polycystic ovary syndrome","volume":"41","year":"2015","journal-title":"J. Obstet. Gynecol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/cns.12538","article-title":"Neuroprotective Role of Steroidal Sex Hormones: An Overview","volume":"22","author":"Siddiqui","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"ref_13","first-page":"193078","article-title":"Polycystic ovary syndrome: Aggressive or protective factor for the retina? Evaluation of macular thickness and retinal nerve fiber layers using high-definition optical coherence tomography","volume":"2015","author":"Garcia","year":"2015","journal-title":"J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.4103\/ijo.IJO_36_22","article-title":"A study of retinal changes in women with polycystic ovarian syndrome","volume":"70","author":"Shiromani","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/trgh.2022.0061","article-title":"Effects of Androgens on the Thickness of Retinal Layers in Transgender Men and in Women with Polycystic Ovarian Syndrome","volume":"8","author":"Alpogan","year":"2023","journal-title":"Transgender Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1177\/1933719114522523","article-title":"Evaluation of the Macula, Retinal Nerve Fiber Layer, and Choroid Thickness in Women With Polycystic Ovary Syndrome Using Spectral-Domain Optical Coherence Tomography","volume":"21","author":"Aksoy","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.29271\/jcpsp.2021.09.1057","article-title":"Optical Coherence Tomography Angiography Findings in Polycystic Ovary Syndrome","volume":"31","author":"Yener","year":"2021","journal-title":"J Coll Physicians Surg Pak."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1080\/02713683.2020.1842460","article-title":"Determination of Neurodegeneration in Polycystic Ovary Syndrome with Retinal Segmentation Analysis","volume":"46","author":"Sirakaya","year":"2020","journal-title":"Curr. Eye Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.4103\/joco.joco_42_22","article-title":"Evaluation of Choroidal Thickness during Pregnancy and Postpartum: A Longitudinal Study","volume":"34","author":"Alizadeh","year":"2022","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_20","first-page":"117","article-title":"Polikistik Over Sendromu Tan\u0131l\u0131 Hastalarda Fundus Bulgular\u0131n\u0131n De\u011ferlendirilmesi","volume":"26","author":"Karaca","year":"2017","journal-title":"Retin. Vitr. J. Retin. Vitr."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Yumusak, E., Ornek, K., Durmaz, S.A., Cifci, A., Guler, H.A., and Bacanli, Z. (2016). Choroidal thickness in obese women. BMC Ophthalmol., 16.","DOI":"10.1186\/s12886-016-0227-z"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4103\/ijo.IJO_295_20","article-title":"Evaluation of the choroidal thickness and retinal nerve fiber layer and visual fields in morbid obesity: Does bariatric surgery affect retinal structure and function?","volume":"69","author":"Gonul","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/09273948.2021.1986546","article-title":"Investigation of the Retinal and Optic Disc Microvascularization in Polycystic Ovary Syndrome: An Optical Coherence Tomography Angiography Study","volume":"31","author":"Elbeyli","year":"2021","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/13816810.2022.2025605","article-title":"Prevalence of ocular anomalies is increased in women with polycystic ovary syndrome\u2014Exploration of association with PAX6 genotype","volume":"43","author":"Zong","year":"2022","journal-title":"Ophthalmic Genet."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/2\/227\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:32:00Z","timestamp":1759919520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/2\/227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["diagnostics15020227"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15020227","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]}}}