{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:40:43Z","timestamp":1775641243012,"version":"3.50.1"},"reference-count":15,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Appendiceal intussusception is a rare condition characterized by the invagination of the appendix into the base of the cecum. In some cases, this condition can lead to obstruction, ischemia, and perforation. It is more common in elderly patients, particularly women, and is often associated with the presence of a lesion, benign or malignant, acting as a \u201clead point.\u201d This case report details the emergency management of a 54-year-old female patient with severe abdominal pain, nausea, and vomiting. The physical examination was unremarkable, as were the laboratory tests. However, ultrasound revealed a small amount of fluid in the pelvis, leading to further investigation with a CT scan which showed appendiceal intussusception with significant wall edema, fluid in the surrounding fatty tissue, and reactive lymph nodes. The patient then underwent an operation that confirmed an intussuscepted appendix showing signs of ischemia. Histopathology showed the presence of an endometrioma acting as the \u201clead point\u201d. This case report showcases the crucial role of diagnostic imaging, which is superior to clinical examination and laboratory tests when diagnosing these patients. Diagnostic imaging, coupled with careful differential diagnosis, is vital to distinguishing benign conditions from malignancy and ensuring timely and appropriate intervention. Early diagnosis and surgical intervention are essential to prevent life-threatening complications such as gangrene and perforation and exclude malignancy in adult patients.<\/jats:p>","DOI":"10.3390\/diagnostics15030256","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T04:54:31Z","timestamp":1737608071000},"page":"256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Appendiceal Intussusception: A Rare Diagnosis and the Role of Imaging in Its Detection"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9855-1633","authenticated-orcid":false,"given":"Stefan","family":"Milo\u0161evi\u0107","sequence":"first","affiliation":[{"name":"Center for Radiology and Magnetic Resonance Imaging, University Clinical Centre of Serbia, Pasterova No. 2, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8082-0120","authenticated-orcid":false,"given":"Miljana","family":"Bubanja","sequence":"additional","affiliation":[{"name":"Center for Radiology and Magnetic Resonance Imaging, University Clinical Centre of Serbia, Pasterova No. 2, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Zugic","sequence":"additional","affiliation":[{"name":"Clinic for Digestive Surgery, University Clinical Centre of Serbia, Koste Todorovica Street, No. 6, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Mitrovic","sequence":"additional","affiliation":[{"name":"Center for Radiology and Magnetic Resonance Imaging, University Clinical Centre of Serbia, Pasterova No. 2, 11000 Belgrade, Serbia"},{"name":"Department for Radiology, Faculty of Medicine, University of Belgrade, Dr Subotica No. 8, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2447-1574","authenticated-orcid":false,"given":"Katarina","family":"Stosic","sequence":"additional","affiliation":[{"name":"Center for Radiology and Magnetic Resonance Imaging, University Clinical Centre of Serbia, Pasterova No. 2, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasko","family":"Tosic","sequence":"additional","affiliation":[{"name":"Clinic for Emergency Surgery, University Clinical Center of Serbia, Koste Todorovica No. 6, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8005-046X","authenticated-orcid":false,"given":"Dragan","family":"Vasin","sequence":"additional","affiliation":[{"name":"Center for Radiology and Magnetic Resonance Imaging, University Clinical Centre of Serbia, Pasterova No. 2, 11000 Belgrade, Serbia"},{"name":"Department for Radiology, Faculty of Medicine, University of Belgrade, Dr Subotica No. 8, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-835X","authenticated-orcid":false,"given":"Aleksandra","family":"Djuric-Stefanovic","sequence":"additional","affiliation":[{"name":"Center for Radiology and Magnetic Resonance Imaging, University Clinical Centre of Serbia, Pasterova No. 2, 11000 Belgrade, Serbia"},{"name":"Department for Radiology, Faculty of Medicine, University of Belgrade, Dr Subotica No. 8, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1111\/ans.16044","article-title":"Missing appendix: Case of complete appendiceal intussusception secondary to endometriosis","volume":"90","author":"Hawkins","year":"2020","journal-title":"ANZ J. Surg."},{"key":"ref_2","first-page":"e27310","article-title":"Concurrent Acute Appendicitis and Type III Appendiceal Intussusception: A Case Report","volume":"14","author":"Hurtado","year":"2022","journal-title":"Cureus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e241592","DOI":"10.1136\/bcr-2021-241592","article-title":"Appendiceal intussusception from endometriosis","volume":"14","author":"Lopez","year":"2021","journal-title":"BMJ Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3941\/jrcr.v14i6.3809","article-title":"CT diagnosis of appendiceal intussusception in a middle-aged female","volume":"14","author":"Miller","year":"2020","journal-title":"J. Radiol. Case Rep."},{"key":"ref_5","first-page":"483","article-title":"Appendiceal intussusception presenting as a caecal mass","volume":"42","author":"Alhamar","year":"2020","journal-title":"Malays. J. 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Int."},{"key":"ref_8","first-page":"uaae032","article-title":"Appendiceal intussusception due to endometriosis presenting as acute right lower quadrant pain","volume":"10","author":"Sandhu","year":"2024","journal-title":"BJR Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"106151","DOI":"10.1016\/j.ijscr.2021.106151","article-title":"Forshal type IE appendiceal intussusception: A case report","volume":"84","author":"Adhikari","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_10","first-page":"1420","article-title":"Adult Intussusception Associated with a Low-Grade Appendiceal Mucinous Neoplasm-A Case Report","volume":"50","author":"Suda","year":"2023","journal-title":"Gan Kagaku Ryoho. Cancer Chemother."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/ans.17218","article-title":"Appendiceal intussusception with appendiceal-caecal fistula in adults caused by acute appendicitis: Case report and literature review","volume":"92","author":"Anandan","year":"2022","journal-title":"ANZ J Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.15441\/ceem.20.026","article-title":"Strangulated appendiceal intussusception caused by isolated endometriosis","volume":"8","author":"Lee","year":"2021","journal-title":"Clin. Exp. Emerg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.5334\/jbsr.2739","article-title":"Appendiceal Intussusception Secondary to Endometriosis: A Rare Etiology of Right Lower Quadrant Abdominal Pain","volume":"106","author":"Trefois","year":"2022","journal-title":"J. Belg. Soc. Radiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"106611","DOI":"10.1016\/j.ijscr.2021.106611","article-title":"Laparoscopic appendectomy for appendiceal intussusception assisted by colonoscopy: A case report","volume":"89","author":"Ohira","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/ans.19127","article-title":"Appendiceal intussusception: What is the appropriate extent of resection?","volume":"94","author":"Jenkin","year":"2024","journal-title":"ANZ J. 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