{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:56:19Z","timestamp":1792090579210,"version":"4.4.0"},"reference-count":89,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) in the pediatric population has emerged as a significant health concern due to its alarming rise in prevalence. In children, the characteristics of the disease differ from those seen in adults. NAFLD may progress to more severe liver disease in children compared to adults with similar profiles. Liver biopsy remains the gold standard for diagnosis; its invasive nature and high cost limit its use as a first-line tool. Alternatively, magnetic resonance imaging (MRI) techniques, such as magnetic resonance imaging-estimated liver proton density fat fraction (MRI-PDFF), have shown a good correlation with the degree of histological steatosis, although their use is limited by high costs and limited accessibility. Controlled attenuation parameter (CAP), integrated with vibration-controlled transient elastography (VCTE) (FibroScan\u00ae), is a novel non-invasive, accessible, and effective method for diagnosing hepatic steatosis. In this article, we reviewed the existing literature on the diagnostic accuracy of CAP in pediatric NAFLD. The PubMed and EMBASE databases were searched. Seven relevant studies were identified, conducted in pediatric hospital populations with specific demographic characteristics. Two of these studies compared CAP with liver biopsy, one compared CAP with liver biopsy and MRI-PDFF, and the remaining four compared CAP with MRI. Overall, CAP proved to be accurate in detecting the presence or absence of fatty infiltration, positioning it as a promising tool to simplify the diagnosis of NAFLD in children. However, further studies in larger populations are needed to confirm these findings and facilitate its implementation in routine clinical practice.<\/jats:p>","DOI":"10.3390\/diagnostics15030299","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:42:23Z","timestamp":1737970943000},"page":"299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating Pediatric NAFLD with Controlled Attenuation Parameter: A Comprehensive Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Ingrid","family":"Arteaga","sequence":"first","affiliation":[{"name":"Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Grup de Recerca en Malalties Hep\u00e0tiques a l\u2019Atenci\u00f3 Prim\u00e0ria (GRemHAp), IDIAP Jordi Gol, USR Metro-Nord, 08303 Matar\u00f3, Spain"},{"name":"Primary Healthcare Center Vall del Tenes, Ger\u00e8ncia d\u2019\u00c0mbit d\u2019Atenci\u00f3 Prim\u00e0ria Metropolitana Nord, Institut Catal\u00e0 de la Salut, 08186 Llic\u00e0 d\u2019Amunt, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Chac\u00f3n","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Grup de Recerca en Malalties Hep\u00e0tiques a l\u2019Atenci\u00f3 Prim\u00e0ria (GRemHAp), IDIAP Jordi Gol, USR Metro-Nord, 08303 Matar\u00f3, Spain"},{"name":"Ph.D. Programme in Medicine and Translational Research, Faculty of Medicine, University of Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0667-1609","authenticated-orcid":false,"given":"Alba","family":"Mart\u00ednez-Escud\u00e9","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Grup de Recerca en Malalties Hep\u00e0tiques a l\u2019Atenci\u00f3 Prim\u00e0ria (GRemHAp), IDIAP Jordi Gol, USR Metro-Nord, 08303 Matar\u00f3, Spain"},{"name":"Primary Healthcare Center La Llagosta, Ger\u00e8ncia d\u2019\u00c0mbit d\u2019Atenci\u00f3 Prim\u00e0ria Metropolitana Nord, Institut Catal\u00e0 de la Salut, 08120 La Llagosta, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Autonomous University of Barcelona, 08193 Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Ruiz","family":"Rojano","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Grup de Recerca en Malalties Hep\u00e0tiques a l\u2019Atenci\u00f3 Prim\u00e0ria (GRemHAp), IDIAP Jordi Gol, USR Metro-Nord, 08303 Matar\u00f3, Spain"},{"name":"Primary Healthcare Center Dr. Barraquer, Ger\u00e8ncia d\u2019\u00c0mbit d\u2019Atenci\u00f3 Prim\u00e0ria Metropolitana Nord, Institut Catal\u00e0 de la Salut, 08930 Sant Adri\u00e0 del Besos, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galadriel","family":"Diez-Fadrique","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Carmona-Cervell\u00f3","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-7427","authenticated-orcid":false,"given":"Pere","family":"Tor\u00e1n-Monserrat","sequence":"additional","affiliation":[{"name":"Unitat de Suport a la Recerca (USR) Metropolitana Nord, Fundaci\u00f3 Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol i Gurina (IDIAP Jordi Gol), 08303 Matar\u00f3, Spain"},{"name":"Grup de Recerca en Malalties Hep\u00e0tiques a l\u2019Atenci\u00f3 Prim\u00e0ria (GRemHAp), IDIAP Jordi Gol, USR Metro-Nord, 08303 Matar\u00f3, Spain"},{"name":"Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"ref_1","first-page":"374","article-title":"Steatohepatitis in Obese Children: A Cause of Chronic Liver Dysfunction","volume":"78","author":"Moran","year":"1983","journal-title":"Am. 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