{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:48:17Z","timestamp":1760057297200,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Aims: Double balloon enteroscopy (DBE) is an innovative method for the diagnosis and management of small bowel (SB) diseases. SB varices are rare disorders, and their diagnosis and treatment can be challenging for clinicians. This study evaluates the use of double balloon enteroscopy (DBE) in diagnosing and treating small bowel varices. Materials and Methods: SB varices were detected in 28 out of 900 double balloon enteroscopy procedures over an 18-year period. Eleven cases of SB varices of various etiologies, diagnosed via DBE, are described. The characteristics of SB varices and endoscopic procedural details were evaluated. Results: A retrospective investigation of 750 patients identified eleven patients (eight males and three females; median age 59 years, range 40\u201380 years) with small bowel varices. The most common site of SB varices was the jejunum. At least one abdominopelvic surgical procedure had been previously performed on five patients. Endotherapy by DBE was administered to nine patients (seven emergent and two prophylactic). Post-endotherapy, three patients experienced bleeding that required re-endotherapy. Endoscopic therapy for small bowel varices included injection sclerotherapy in eight cases (six with cyanoacrylate and two with polidocanol) and injection sclerotherapy plus hemoclipping in one case. Conclusions: SB varices can present a diagnostic challenge for clinicians. DBE is a valuable tool for both the diagnosis and management of small bowel varices.<\/jats:p>","DOI":"10.3390\/diagnostics15030336","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:42:36Z","timestamp":1738305756000},"page":"336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of Double Balloon Enteroscopy in the Diagnosis and Treatment of Small Bowel Varices"],"prefix":"10.3390","volume":"15","author":[{"given":"Suleyman","family":"Dolu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Dokuz Eyl\u00fcl University, Izmir 35340, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-5129","authenticated-orcid":false,"given":"Mehmet Emin","family":"Arayici","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Faculty of Medicine, Dokuz Eyl\u00fcl University, Izmir 35340, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-7567","authenticated-orcid":false,"given":"Soner","family":"Onem","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Samsun Training and Research Hospital, Samsun 55090, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilker","family":"Buyuktorun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Dokuz Eyl\u00fcl University, Izmir 35340, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4032-9209","authenticated-orcid":false,"given":"Huseyin","family":"Dongelli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Dokuz Eyl\u00fcl University, Izmir 35340, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7859-4094","authenticated-orcid":false,"given":"Goksel","family":"Bengi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine, Dokuz Eyl\u00fcl University, Izmir 35340, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesut","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Private Gastroenterology Clinic, Izmir 35535, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"106299","DOI":"10.1016\/j.ijscr.2021.106299","article-title":"Isolated Ectopic Jejunal Varices in a Patient with Extrahepatic Portal Vein Obstruction\u2014A Case Report","volume":"86","author":"Solanki","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_2","first-page":"273","article-title":"Advanced Therapy by Device-Assisted Enteroscopy","volume":"112","year":"2020","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12072-008-9074-1","article-title":"Updates in the Pathogenesis, Diagnosis and Management of Ectopic Varices","volume":"2","author":"Helmy","year":"2008","journal-title":"Hepatol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13256-015-0705-6","article-title":"Small Bowel Varices Secondary to Chronic Superior Mesenteric Vein Thrombosis in a Patient with Heterozygous Factor V Leiden Mutation: A Case Report","volume":"9","author":"Garcia","year":"2015","journal-title":"J. Med. Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/hep.510280434","article-title":"Management of Ectopic Varices","volume":"28","author":"Norton","year":"1998","journal-title":"Hepatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cld.95","article-title":"Ectopic Varices","volume":"1","author":"Sarin","year":"2012","journal-title":"Clin. Liver Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bosch, E.M., Laskaratos, F.-M., Sodergren, M., Faiz, O., and Humphries, A. (2024). The Role of Small-Bowel Endoscopy in the Diagnosis and Management of Small-Bowel Neuroendocrine Tumours. J. Clin. Med., 13.","DOI":"10.3390\/jcm13226877"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5946\/ce.2022.131","article-title":"Endoscopic and Histological Characteristics of Small Bowel Tumors Diagnosed by Double-Balloon Enteroscopy","volume":"56","author":"Dolu","year":"2023","journal-title":"Clin. Endosc."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Igawa, A., Oka, S., Tanaka, S., Kunihara, S., Nakano, M., Aoyama, T., and Chayama, K. (2015). Major Predictors and Management of Small-Bowel Angioectasia. BMC Gastroenterol., 15.","DOI":"10.1186\/s12876-015-0337-8"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Dolu, S., Arayici, M.E., Onem, S., Buyuktorun, I., Dongelli, H., Bengi, G., and Akarsu, M. (2025). Evaluation of Double-Balloon Enteroscopy in the Management of Type 1 Small Bowel Vascular Lesions (Angioectasia): A Retrospective Cohort Study. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-03591-x"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.gie.2010.09.030","article-title":"Duodenal Variceal Bleeding Successfully Treated with Endoscopic Banding (with Video)","volume":"74","author":"Schmeltzer","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/sjg.SJG_50_20","article-title":"Clinical Characteristics and Efficacy of Endoscopic Treatment of Gastrointestinal Ectopic Varices: A Single-Center Study","volume":"27","author":"Yipeng","year":"2021","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.gie.2007.08.027","article-title":"Complete Eradication of Duodenal Varices after Endoscopic Injection Sclerotherapy with Ethanolamine Oleate: A Case Report","volume":"67","author":"Seo","year":"2008","journal-title":"Gastrointest. Endosc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4321\/S1130-01082008000300008","article-title":"Successful Endoscopic Banding after Cyanoacrylate Failure for Active Bleeding Duodenal Varix","volume":"100","author":"Sousa","year":"2008","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_15","first-page":"e65959","article-title":"Small Intestine Ectopic Varices as a Cause of Obscure Gastrointestinal Bleeding in a Cirrhotic Patient","volume":"16","author":"Abosheaishaa","year":"2024","journal-title":"Cureus"},{"key":"ref_16","first-page":"60","article-title":"Bleeding from Gastrointestinal Ectopic Varices Is Not Associated with Haemorrhage from Oesophageal or Gastric Varices","volume":"15","year":"2020","journal-title":"Prz. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1872-034X.2010.00690.x","article-title":"Current Status of Ectopic Varices in Japan: Results of a Survey by the Japan Society for Portal Hypertension","volume":"40","author":"Watanabe","year":"2010","journal-title":"Hepatol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"960720","DOI":"10.4061\/2011\/960720","article-title":"Clinicopathological Features and Treatment of Ectopic Varices with Portal Hypertension","volume":"2011","author":"Sato","year":"2011","journal-title":"Int. J. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0300-5089(21)00639-8","article-title":"Ectopic Varices in Portal Hypertension","volume":"14","author":"Lebrec","year":"1985","journal-title":"Clin. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0016-5107(05)01588-9","article-title":"Mucosal Abnormalities of the Small Bowel in Patients with Cirrhosis and Portal Hypertension: A Capsule Endoscopy Study","volume":"62","author":"Rega","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s10620-012-2502-z","article-title":"Small Bowel Abnormalities in Patients with Compensated Liver Cirrhosis","volume":"58","author":"Aoyama","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0016-5107(04)01458-0","article-title":"Diagnosis of Small-Bowel Varices by Capsule Endoscopy","volume":"60","author":"Tang","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.14218\/JCTH.2023.00061","article-title":"Guidelines for the Management of Esophagogastric Variceal Bleeding in Cirrhotic Portal Hypertension","volume":"11","author":"Xu","year":"2023","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII Faculty Baveno VII\u2014Renewing Consensus in Portal Hypertension","volume":"76","author":"Bosch","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.gie.2019.03.1171","article-title":"Double-Balloon Enteroscopy-Facilitated Cyanoacrylate-Injection Endotherapy of Small-Bowel Varices: An International Experience from 2 European Tertiary Centers (with Videos)","volume":"90","author":"Despott","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.gie.2006.07.001","article-title":"Endoscopic N-Butyl-2-Cyanoacrylate (Histoacryl) Obliteration of Jejunal Varices by Using the Double Balloon Enteroscope","volume":"65","author":"Hekmat","year":"2007","journal-title":"Gastrointest. 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