{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:43:06Z","timestamp":1770842586554,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Road traffic accidents (RTAs) are a leading cause of morbidity and mortality worldwide, frequently resulting in traumatic brain injuries (TBIs), skull fractures, and spinal injuries. This manuscript examines the forensic aspects of head trauma caused by RTAs, focusing on the role of autopsy and imaging in diagnosing and characterizing injuries. Through a systematic review of the literature, the study highlights the mechanisms of injury, including high-speed collisions, whiplash, and pedestrian impacts, and explores their pathological consequences, such as subarachnoid hemorrhage, intracranial hemorrhage, and diffuse axonal injury. The differentiation between traumatic and non-traumatic conditions, such as aneurysmal subarachnoid hemorrhage, is emphasized to ensure accurate clinical and forensic assessments. Advances in imaging technologies, particularly virtopsy, are discussed for their potential in non-invasive documentation and analysis of head injuries, while limitations of this approach are acknowledged. Furthermore, the manuscript underscores the importance of preventive measures, including helmet and seatbelt use, vehicle safety innovations, and improved road design, in reducing the incidence and severity of RTAs. By integrating clinical, forensic, and preventive perspectives, this study provides a comprehensive framework for understanding and addressing the burden of head trauma related to RTAs.<\/jats:p>","DOI":"10.3390\/diagnostics15040442","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T03:41:57Z","timestamp":1739331717000},"page":"442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Autopsy in the Forensic and Clinical Evaluation of Head Trauma and Traumatic Brain Injury in Road Traffic Accidents: A Review of the Literature"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-3742","authenticated-orcid":false,"given":"Matteo Antonio","family":"Sacco","sequence":"first","affiliation":[{"name":"Institute of Legal Medicine, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Verrina","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Raffaele","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saverio","family":"Gualtieri","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Pasquale","family":"Tarallo","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santo","family":"Gratteri","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-6050","authenticated-orcid":false,"given":"Isabella","family":"Aquila","sequence":"additional","affiliation":[{"name":"Institute of Legal Medicine, Department of Medical and Surgical Sciences, \u201cMagna Graecia\u201d University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.injury.2021.02.028","article-title":"Geographical mapping of road traffic injuries in Lilongwe, Malawi","volume":"52","author":"Sundet","year":"2021","journal-title":"Injury"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12961-018-0298-9","article-title":"A bibliometric analysis of the published road traffic injuries research in India, post-1990","volume":"16","author":"Sharma","year":"2018","journal-title":"Health Res. Policy Syst."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/tropej\/46.2.64","article-title":"Road traffic accidents","volume":"46","author":"Simkiss","year":"2000","journal-title":"J. Trop. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/s-0040-1709363","article-title":"The Epidemiology of Traumatic Brain Injury Due to Traffic Accidents in Latin America: A Narrative Review","volume":"11","author":"Dunne","year":"2020","journal-title":"J. Neurosci. Rural Pract."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.23736\/S0390-5616.18.04532-0","article-title":"Epidemiology of severe traumatic brain injury","volume":"62","author":"Iaccarino","year":"2018","journal-title":"J. Neurosurg. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/eurpub\/cks074","article-title":"Traumatic brain injuries caused by traffic accidents in five European countries: Outcome and public health consequences","volume":"23","author":"Majdan","year":"2013","journal-title":"Eur. J. Public Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic brain injury: Progress and challenges in prevention, clinical care, and research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00068-017-0885-4","article-title":"Clinical characteristics and prognosis of traumatic head injury following road traffic accidents admitted in ICU \u201canalysis of 694 cases\u201d","volume":"45","author":"Chelly","year":"2019","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jsr.2020.02.010","article-title":"A 6-year survey of road traffic accidents in Southwest China: Emphasis on traumatic brain injury","volume":"73","author":"Duan","year":"2020","journal-title":"J. Saf. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s12024-022-00503-3","article-title":"Causes of fatalities in motor vehicle occupants: An overview","volume":"18","author":"Baldock","year":"2022","journal-title":"Forensic Sci. Med. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4103\/JETS.JETS_127_17","article-title":"Clinical Profile and Autopsy Findings in Fatal Head Injuries","volume":"11","author":"Alexis","year":"2018","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"fcac033","DOI":"10.1093\/braincomms\/fcac033","article-title":"The relationship between road traffic collision dynamics and traumatic brain injury pathology","volume":"4","author":"Baker","year":"2022","journal-title":"Brain Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-0-444-52892-6.00004-0","article-title":"The neuropathology of traumatic brain injury","volume":"127","author":"Mckee","year":"2015","journal-title":"Handb. Clin. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-3-7091-0693-8_11","article-title":"Intracranial hemorrhage: Mechanisms of secondary brain injury","volume":"111","author":"Lok","year":"2011","journal-title":"Acta Neurochir. Suppl."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/pathophysiology30030032","article-title":"Pathophysiology, Management, and Therapeutics in Subarachnoid Hemorrhage and Delayed Cerebral Ischemia: An Overview","volume":"30","author":"Sanicola","year":"2023","journal-title":"Pathophysiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e639","DOI":"10.1016\/j.wneu.2014.06.022","article-title":"Traumatic subarachnoid hemorrhage due to motor vehicle crash versus fall from height: A 4-year epidemiologic study","volume":"82","author":"Parchani","year":"2014","journal-title":"World Neurosurg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/brain\/124.2.249","article-title":"Subarachnoid haemorrhage: Diagnosis, causes and management","volume":"124","author":"Rinkel","year":"2001","journal-title":"Brain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/neu.2013.3111","article-title":"Injury pattern, hospital triage, and mortality of 1250 patients with severe traumatic brain injury caused by road traffic accidents","volume":"31","author":"Leijdesdorff","year":"2014","journal-title":"J. Neurotrauma"},{"key":"ref_19","unstructured":"Tenny, S., and Thorell, W. (2024, December 02). Intracranial Hemorrhage. [Updated 2024 Feb 17], StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470242\/."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13311-010-0003-3","article-title":"Imaging for the diagnosis and management of traumatic brain injury","volume":"8","author":"Kim","year":"2011","journal-title":"Neurotherapeutics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.nec.2016.05.011","article-title":"Imaging Evaluation of Acute Traumatic Brain Injury","volume":"27","author":"Mutch","year":"2016","journal-title":"Neurosurg. Clin. N. Am."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100028","DOI":"10.1016\/j.acpath.2022.100028","article-title":"Educational Case: Cranial hemorrhage and traumatic brain injury","volume":"9","author":"Stalons","year":"2022","journal-title":"Acad. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.7150\/ijms.54913","article-title":"Clinical predictors of prognosis in patients with traumatic brain injury combined with extracranial trauma","volume":"18","author":"Liu","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_24","first-page":"160","article-title":"Investigation of fatal traumatic head injuries","volume":"30","author":"Bork","year":"2024","journal-title":"Turk. J. Trauma Emerg. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/1556-4029.14149","article-title":"The frequency of cranial base fractures in lethal head trauma","volume":"65","author":"Crudele","year":"2020","journal-title":"J. Forensic Sci."},{"key":"ref_26","first-page":"289","article-title":"Pattern of injuries in road traffic accidents at Peshawar: An autopsy based study","volume":"30","author":"Wasif","year":"2022","journal-title":"J. Med. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5249\/jivr.v2i2.46","article-title":"Skull fracture and haemorrhage pattern among fatal and nonfatal head injury assault victims\u2014A critical analysis","volume":"2","author":"Chattopadhyay","year":"2010","journal-title":"J. Inj. Violence Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"101697","DOI":"10.1016\/j.legalmed.2020.101697","article-title":"Finite element analysis to determine the cause of ring fractures in a motorcyclist\u2019s head","volume":"45","author":"Jia","year":"2020","journal-title":"Leg. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.48165\/jiafm.2024.46.1.16","article-title":"Comprehensive Analysis of Fatal Road Accidents: Patterns and Characteristics of Injuries in a Forensic Medicine Setting","volume":"46","author":"Pati","year":"2024","journal-title":"J. Indian. Acad. Forensic Med."},{"key":"ref_30","first-page":"H1","article-title":"A comprehensive study of deaths due to cervical spine injuries in various cases reported at a tertiary care hospital mortuary during the period of January to December 2015","volume":"6","author":"Rajasekhar","year":"2019","journal-title":"Int. J. Contemp. Med. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"105571","DOI":"10.1016\/j.aap.2020.105571","article-title":"Estimating the number of traffic crash-related cervical spine injuries in the United States; An analysis and comparison of national crash and hospital data","volume":"142","author":"Freeman","year":"2020","journal-title":"Accid. Anal. Prev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4103\/IJCIIS.IJCIIS_16_19","article-title":"The age and gender distribution of patients admitted following nonfatal road traffic accidents in Riyadh: A cross-sectional study","volume":"10","author":"Gorge","year":"2020","journal-title":"Int. J. Crit. Illn. Inj. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ienj.2008.07.007","article-title":"Incidence and severity of head and neck injuries in victims of road traffic crashes: In an economically developed country","volume":"17","author":"Bener","year":"2009","journal-title":"Int. Emerg. Nurs."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/tse\/tdz012","article-title":"A review of neck injury and protection in vehicle accidents","volume":"1","author":"Li","year":"2019","journal-title":"Transp. Saf. Environ."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1754-9493-3-5","article-title":"Deceleration during \u2019real life\u2019 motor vehicle collisions\u2014A sensitive predictor for the risk of sustaining a cervical spine injury?","volume":"3","author":"Elbel","year":"2009","journal-title":"Patient Saf. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s12024-021-00442-5","article-title":"Issues that arise in the assessment of pedestrian deaths","volume":"18","author":"Byard","year":"2022","journal-title":"Forensic Sci. Med. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.expneurol.2012.01.013","article-title":"Axonal pathology in traumatic brain injury","volume":"246","author":"Johnson","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/1925362118797728","article-title":"Histology of Brain Trauma and Hypoxia-Ischemia","volume":"8","author":"Rahaman","year":"2018","journal-title":"Acad. Forensic Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Frank, D., Gruenbaum, B.F., Shelef, I., Zvenigorodsky, V., Benjamin, Y., Shapoval, O., Gal, R., Zlotnik, A., Melamed, I., and Boyko, M. (2021). A Novel Histological Technique to Assess Severity of Traumatic Brain Injury in Rodents: Comparisons to Neuroimaging and Neurological Outcomes. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.733115"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sacco, M.A., Gualtieri, S., Tarda, L., Ricci, P., and Aquila, I. (2023). Clinical and Forensic Investigation Protocols for Diagnosing Abusive Head Trauma: A Literature Review. Diagnostics, 13.","DOI":"10.3390\/diagnostics13193093"},{"key":"ref_41","first-page":"CD001855","article-title":"Helmets for preventing head and facial injuries in bicyclists","volume":"1999","author":"Thompson","year":"2000","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5847\/wjem.j.1920-8642.2021.01.011","article-title":"Effectiveness of seatbelts in mitigating traumatic brain injury severity","volume":"12","author":"Ganti","year":"2021","journal-title":"World J. Emerg. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.afjem.2020.05.006","article-title":"Emergency department management of traumatic brain injuries: A resource tiered review","volume":"10","author":"Dixon","year":"2020","journal-title":"Afr. J. Emerg. Med."},{"key":"ref_44","first-page":"146","article-title":"Virtopsy (virtual autopsy): A new phase in forensic investigation","volume":"5","author":"Tejaswi","year":"2013","journal-title":"J. Forensic Dent. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"200389","DOI":"10.1016\/j.fri.2020.200389","article-title":"Comparison of postmortem CT and conventional autopsy in five trauma fatalities","volume":"22","author":"Worasuwannarak","year":"2020","journal-title":"Forensic Imaging"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"200361","DOI":"10.1016\/j.fri.2020.200361","article-title":"The approach of virtual autopsy (VIRTOPSY) by postmortem multi-slice computed tomography (PMCT) in China for forensic pathology","volume":"20","author":"Wan","year":"2020","journal-title":"Forensic Imaging"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/jpi.jpi_23_18","article-title":"Virtual Autopsy as a Screening Test Before Traditional Autopsy: The Verona Experience on 25 Cases","volume":"9","author":"Cirielli","year":"2018","journal-title":"J. Pathol. Inform."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1520\/JFS2003378","article-title":"Virtopsy\u2013fatal motor vehicle accident with head injury","volume":"49","author":"Aghayev","year":"2004","journal-title":"J. Forensic Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s41935-023-00344-3","article-title":"Comparative study of postmortem computed tomography (PMCT) against traditional forensic autopsy findings in fatal road traffic accidents\u2014A pilot analysis","volume":"13","author":"Khan","year":"2023","journal-title":"Egypt. J. Forensic Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s12024-022-00541-x","article-title":"Young adults in motor vehicle collisions in Norway: User safety errors observed in majority of cases with severe or fatal injuries","volume":"18","author":"Breen","year":"2022","journal-title":"Forensic Sci. Med. Pathol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/4\/442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:31:49Z","timestamp":1760027509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/15\/4\/442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["diagnostics15040442"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics15040442","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,12]]}}}