{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T20:26:13Z","timestamp":1775939173683,"version":"3.50.1"},"reference-count":86,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Madelung\u2019s disease is a rare lipid metabolic disorder characterized by diffuse and symmetrical adipose tissue deposits in the subcutaneous fascial spaces, presenting with multiple painless masses throughout the body. The disease is more common in middle-aged adults with a history of chronic alcohol consumption. Case Report: This article reports a case of Madelung\u2019s disease from Romania in a 67-year-old man admitted to our department for multiple adipose masses located in the neck and upper back. MRI examination of the head and neck revealed symmetrical and non-encapsulated fat deposition. Surgical intervention was performed to resect the adipose masses. The article also discusses the etiology, clinical manifestations, diagnosis, and surgical treatment of large adipose lesions. Conclusions: This case report provides insights for the diagnosis and treatment of Madelung\u2019s syndrome.<\/jats:p>","DOI":"10.3390\/diagnostics15040459","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T10:36:58Z","timestamp":1739443018000},"page":"459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Case Report of Madelung\u2019s Disease in Romania"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-1751","authenticated-orcid":false,"given":"Andrei Ionut","family":"Cucu","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Biological Sciences, University Stefan cel Mare of Suceava, 720229 Suceava, Romania"},{"name":"Emergency Clinical Hospital Prof. Dr. Nicolae Oblu, 700309 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Sava","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital Prof. Dr. Nicolae Oblu, 700309 Iasi, Romania"},{"name":"Department of Morpho-Functional Sciences I, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa Iasi, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2874-9227","authenticated-orcid":false,"given":"Amelian Madalin","family":"Bobu","sequence":"additional","affiliation":[{"name":"St. Spiridon County Clinical Emergency Hospital Iasi, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2488-2154","authenticated-orcid":false,"given":"Claudia Florida","family":"Costea","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital Prof. Dr. Nicolae Oblu, 700309 Iasi, Romania"},{"name":"Department of Ophthalmology, University of Medicine and Pharmacy Grigore T. Popa Iasi, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlad Liviu","family":"Hartie","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital Prof. Dr. Nicolae Oblu, 700309 Iasi, Romania"},{"name":"Department of Anesthesia and Intensive Care, University of Medicine and Pharmacy Grigore T. Popa Iasi, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-985X","authenticated-orcid":false,"given":"Emilia","family":"Patrascanu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, University of Medicine and Pharmacy Grigore T. Popa Iasi, 700115 Iasi, Romania"},{"name":"Regional Institute of Oncology, 700483 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurentiu Andrei","family":"Blaj","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital Prof. Dr. Nicolae Oblu, 700309 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalin Mihai","family":"Buzduga","sequence":"additional","affiliation":[{"name":"St. Spiridon County Clinical Emergency Hospital Iasi, 700111 Iasi, Romania"},{"name":"Department of Endocrinology, University of Medicine and Pharmacy Grigore T. Popa Iasi, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences I, Faculty of Medicine, University of Medicine and Pharmacy Grigore T. 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Popa Iasi, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.radcr.2021.10.035","article-title":"A Case Report of Madelung\u2019s Disease in China","volume":"17","author":"Wanke","year":"2022","journal-title":"Radiol. Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s00266-020-02083-5","article-title":"Madelung Disease Epidemiology and Clinical Characteristics: A Systemic Review","volume":"45","author":"Liu","year":"2021","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_3","first-page":"400","article-title":"Madelung Disease","volume":"32","author":"Lewicki","year":"2015","journal-title":"Adv. Dermatol. Allergol."},{"key":"ref_4","first-page":"166","article-title":"Madelung\u2019s Disease","volume":"64","year":"2013","journal-title":"Acta Otorrinolaringol. 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