{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:25:48Z","timestamp":1787955948634,"version":"build-2784847793"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Atopic dermatitis (AD) and alopecia areata (AA) frequently coexist due to shared immune-mediated mechanisms. Treatments targeting AD, including Janus kinase (JAK) inhibitors and dupilumab, may impact AA outcomes in unpredictable ways. This study aims to evaluate the effects of advanced therapies on patients with concurrent AD and AA to inform treatment strategies. Methods: A retrospective cohort study was conducted on six patients diagnosed with both AD and AA. Treatments included systemic corticosteroids, dupilumab, and JAK inhibitors (baricitinib and upadacitinib). Outcomes were assessed at six months using the Severity of Alopecia Tool (SALT), Dermatology Life Quality Index (DLQI), and Scoring Atopic Dermatitis (SCORAD) scores. Results: Patients receiving JAK inhibitors showed significant improvements in AD and AA outcomes, with mean reductions of 95.65% in SALT scores, 91.03% in DLQI scores, and 89.57% in SCORAD scores. Dupilumab was associated with the onset or worsening of AA in two patients. Systemic corticosteroids provided short-term benefits but are unsuitable for long-term management due to safety concerns. Conclusions: JAK inhibitors are effective for managing concurrent AD and AA, offering substantial improvements in disease control and quality of life. However, dupilumab requires cautious use in patients with these comorbid conditions. Personalized treatment strategies, informed by patient-specific factors, are essential for optimizing outcomes and minimizing risks. Further research is needed to identify predictive markers and refine therapeutic approaches for this challenging population.<\/jats:p>","DOI":"10.3390\/diagnostics15050520","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T11:03:37Z","timestamp":1740049417000},"page":"520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual Relief: How Atopic Dermatitis Treatments Affect Alopecia Areata\u2014A Small Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Daciana Elena","family":"Br\u0103ni\u0219teanu","sequence":"first","affiliation":[{"name":"Discipline of Dermatology, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"},{"name":"Railways Universitary Hospital, Dermatology Clinic, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia-Elena","family":"Hu\u021banu","sequence":"additional","affiliation":[{"name":"Railways Universitary Hospital, Dermatology Clinic, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5147-9596","authenticated-orcid":false,"given":"Daniel Constantin","family":"Br\u0103ni\u0219teanu","sequence":"additional","affiliation":[{"name":"Discipline of Ophtalmology, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"},{"name":"Railways Universitary Hospital, Ophtalmology Clinic, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Colac-Bo\u021boc","sequence":"additional","affiliation":[{"name":"Railways Universitary Hospital, Dermatology Clinic, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana Paraschiva","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Railways Universitary Hospital, Dermatology Clinic, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103t\u0103lina-Anca","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Railways Universitary Hospital, Dermatology Clinic, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin Gabriel","family":"Colac","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Br\u0103ni\u0219teanu","sequence":"additional","affiliation":[{"name":"Recovery Hospital, Orthopedy Clinic, 14 Pantelimon Halipa Str., 700661 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103t\u0103lina","family":"Onu-Br\u0103ni\u0219teanu","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases C.C. Iliescu, 258 Fundeni Str., 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicu\u021ba","family":"Manolache","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-836X","authenticated-orcid":false,"given":"Mihaela-Paula","family":"Toader","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases C.C. Iliescu, 258 Fundeni Str., 022328 Bucharest, Romania"},{"name":"Discipline of Oral Medicine, Oral Dermatology, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-2066","authenticated-orcid":false,"given":"Elena","family":"Porumb-Andrese","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"},{"name":"Railways Universitary Hospital, Dermatology Clinic, 1 Garabet Ibraileanu Str., 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.mcna.2023.08.012","article-title":"Atopic Dermatitis","volume":"108","author":"Karl","year":"2024","journal-title":"Med. Clin. N. 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