{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:07:39Z","timestamp":1787652459990,"version":"build-2736575974"},"reference-count":13,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["CIFMS-2021-I2M-1-002"],"award-info":[{"award-number":["CIFMS-2021-I2M-1-002"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2022-PUMCH-B-071"],"award-info":[{"award-number":["2022-PUMCH-B-071"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2022-PUMCH-C-003"],"award-info":[{"award-number":["2022-PUMCH-C-003"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["CIFMS-2021-I2M-1-002"],"award-info":[{"award-number":["CIFMS-2021-I2M-1-002"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-071"],"award-info":[{"award-number":["2022-PUMCH-B-071"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-C-003"],"award-info":[{"award-number":["2022-PUMCH-C-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A 30-year-old woman presented with progressive edema and mild diarrhea. Laboratory examination revealed hypoalbuminemia. She underwent 99mTc-antimony sulphide colloid (99mTc-ASC) lymphoscintigraphy to evaluate potential loss of protein through gastrointestinal tract caused by lymphatic leakage and detect abnormalities in the lymphatic systems. The images showed abnormal leakage of radiotracers in the bowel, suggestive of protein loss through the gastrointestinal tract. Abnormal visualization of the lower part of thoracic duct and bilateral venous angle was also demonstrated on 99mTc-ASC scintigraphy. It suggested secondary intestinal lymphangiectasis caused by lymphatic obstruction and reflux. Enhanced CT reconstruction of the small intestine revealed roughness and thickening of intestinal wall, consistent with the diagnosis of protein-losing enteropathy.<\/jats:p>","DOI":"10.3390\/diagnostics15050583","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T06:45:42Z","timestamp":1740725142000},"page":"583","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Protein-Losing Enteropathy Demonstrated by 99mTc-ASC Lymphoscintigraphy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4929-1923","authenticated-orcid":false,"given":"Jingnan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, State Key Laboratory of Complex, Severe, and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, State Key Laboratory of Complex, Severe, and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, State Key Laboratory of Complex, Severe, and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/ajg.2009.561","article-title":"Protein-losing enteropathy: Case illustrations and clinical review","volume":"105","author":"Umar","year":"2010","journal-title":"Am. 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Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e20995","DOI":"10.1097\/MD.0000000000020995","article-title":"Intestinal lymphangiectasia in a 3-month-old girl: A case report of Hennekam syndrome caused by CCBE1 mutation","volume":"99","author":"Fattorusso","year":"2020","journal-title":"Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.21037\/gs-2019-ursoc-10","article-title":"Novel interventional radiological management for lymphatic leakages after gynecologic surgery: Lymphangiography and embolization","volume":"10","author":"Hur","year":"2021","journal-title":"Gland. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e00388","DOI":"10.14309\/crj.0000000000000388","article-title":"Diagnosis of a Lymphoenteric Fistula by Single-Photon Emission Computed Tomography\/Computed Tomography Lymphoscintigraphy","volume":"7","author":"Anantharachagan","year":"2020","journal-title":"ACG Case Rep. 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